{"id":"https://openalex.org/W797373748","doi":null,"title":"What constrains directional selection on complex traits in the wild","display_name":"What constrains directional selection on complex traits in the wild","publication_year":2011,"publication_date":"2011-08-31","ids":{"openalex":"https://openalex.org/W797373748","mag":"797373748"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/8168","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/8168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075941428","display_name":"Julius P. Mojica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julius P. Mojica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075941428"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/directional-selection","display_name":"directional selection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/complex-traits","display_name":"complex traits","score":0.949999988079071},{"id":"https://openalex.org/keywords/maintenance-of-genetic-variation","display_name":"maintenance of genetic variation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/mimulus-guttatus","display_name":"Mimulus guttatus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/flower-size","display_name":"flower size","score":0.9829999804496765},{"id":"https://openalex.org/keywords/viability-selection","display_name":"viability selection","score":0.6759999990463257},{"id":"https://openalex.org/keywords/fitness-trade-offs","display_name":"fitness trade-offs","score":0.8069999814033508},{"id":"https://openalex.org/keywords/fecundity","display_name":"fecundity","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fluctuating-selection","display_name":"fluctuating selection","score":0.7950000166893005},{"id":"https://openalex.org/keywords/indirect-selection","display_name":"indirect selection","score":0.7289999723434448},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/near-isogenic-lines","display_name":"near-isogenic lines","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6507128477096558},{"id":"https://openalex.org/C90032942","wikidata":"https://www.wikidata.org/wiki/Q764759","display_name":"Directional selection","level":4,"score":0.47874706983566284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3809836208820343},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3745654821395874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2796422839164734},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27009743452072144},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.19924822449684143}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/8168","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/8168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:797373748","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/8168","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W100674101","https://openalex.org/W105850798","https://openalex.org/W1498210519","https://openalex.org/W1518765418","https://openalex.org/W1525285200","https://openalex.org/W1629867331","https://openalex.org/W1854341434","https://openalex.org/W1882609858","https://openalex.org/W1950565592","https://openalex.org/W1974850613","https://openalex.org/W1974956282","https://openalex.org/W1980370516","https://openalex.org/W1981455906","https://openalex.org/W1986378002","https://openalex.org/W1987052543","https://openalex.org/W1987449446","https://openalex.org/W2005901203","https://openalex.org/W2016968715","https://openalex.org/W2019231894","https://openalex.org/W2025603936","https://openalex.org/W2027730564","https://openalex.org/W2028121173","https://openalex.org/W2028277546","https://openalex.org/W2031820690","https://openalex.org/W2033732079","https://openalex.org/W2034765123","https://openalex.org/W2034941133","https://openalex.org/W2035457902","https://openalex.org/W2039013541","https://openalex.org/W2042703056","https://openalex.org/W2044955766","https://openalex.org/W2047366062","https://openalex.org/W2047495447","https://openalex.org/W2051004220","https://openalex.org/W2054685215","https://openalex.org/W2059207042","https://openalex.org/W2059433014","https://openalex.org/W2061758767","https://openalex.org/W2064947972","https://openalex.org/W2072518533","https://openalex.org/W2073587913","https://openalex.org/W2078701932","https://openalex.org/W2080430923","https://openalex.org/W2080618944","https://openalex.org/W2080715625","https://openalex.org/W2085683389","https://openalex.org/W2093768200","https://openalex.org/W2097499532","https://openalex.org/W2097976051","https://openalex.org/W2098258247","https://openalex.org/W2101100756","https://openalex.org/W2105893696","https://openalex.org/W2108874649","https://openalex.org/W2109428038","https://openalex.org/W2111780375","https://openalex.org/W2113212096","https://openalex.org/W2115254746","https://openalex.org/W2116036555","https://openalex.org/W2119373354","https://openalex.org/W2120464499","https://openalex.org/W2122068366","https://openalex.org/W2124548143","https://openalex.org/W2125867410","https://openalex.org/W2127196923","https://openalex.org/W2131580342","https://openalex.org/W2135370544","https://openalex.org/W2137031701","https://openalex.org/W2138458424","https://openalex.org/W2141088880","https://openalex.org/W2145480244","https://openalex.org/W2146740976","https://openalex.org/W2150751216","https://openalex.org/W2152491803","https://openalex.org/W2155657519","https://openalex.org/W2156866331","https://openalex.org/W2156886335","https://openalex.org/W2156918287","https://openalex.org/W2160199880","https://openalex.org/W2166643118","https://openalex.org/W2168457941","https://openalex.org/W2172651767","https://openalex.org/W2175258576","https://openalex.org/W2176694411","https://openalex.org/W2313940787","https://openalex.org/W2321750615","https://openalex.org/W2322715144","https://openalex.org/W2323315552","https://openalex.org/W2326563305","https://openalex.org/W2326607089","https://openalex.org/W2328302997","https://openalex.org/W2329454707","https://openalex.org/W2330584255","https://openalex.org/W2335268614","https://openalex.org/W4250353446"],"related_works":["https://openalex.org/W2116036555","https://openalex.org/W2078701932","https://openalex.org/W6910975005","https://openalex.org/W3146703125","https://openalex.org/W4248507511","https://openalex.org/W4384940734","https://openalex.org/W4249509586","https://openalex.org/W2164411873","https://openalex.org/W3145467512","https://openalex.org/W7138269207"],"abstract_inverted_index":{"The":[0],"fact":[1],"that":[2,46,111,127,163,181,236,251],"abundant":[3,87],"genetic":[4,88,246],"variation":[5,65,89],"persists":[6],"within":[7],"populations":[8],"despite":[9],"strong":[10,91],"directional":[11,92,99,169,220],"selection":[12,50,93,129,154,170,198,210,221,242],"on":[13,51,202,211],"complex":[14,53],"traits":[15,250],"is":[16,118,239],"one":[17],"of":[18,61,109,140,168,206,259],"the":[19,44,57,70,78,95,104,115,136,156,166,172,216,255],"unresolved":[20],"conundrums":[21],"in":[22,66,83,94,121,171,227,254],"evolutionary":[23,217],"biology.":[24],"In":[25,142],"this":[26],"dissertation,":[27],"I":[28,55,145,179,194,225],"employed":[29],"a":[30,52,203,231],"multi-faceted":[31],"approach":[32],"combining":[33],"classical":[34],"and":[35,59,63,138,150,152,158,201],"modern":[36],"genomic":[37],"methods":[38],"with":[39,248],"field":[40,256],"studies":[41],"to":[42,131,219,244],"identify":[43],"factors":[45,162],"may":[47,214],"reduce":[48,165,191],"total":[49],"trait.":[54],"investigated":[56],"causes":[58],"consequences":[60],"phenotypic":[62,233],"genotypic":[64],"flower":[67,72,184,223],"size":[68,82,185],"using":[69,230],"wild":[71],"Mimulus":[73,84],"guttatus":[74,85],"(yellow":[75],"monkeyflower)":[76],"as":[77,161],"model":[79],"system.":[80],"Flower":[81],"exhibits":[86],"amidst":[90],"wild.":[96,173],"To":[97],"understand":[98],"selection,":[100],"we":[101],"must":[102],"consider":[103],"\"invisible":[105],"fraction\"":[106],"(the":[107],"proportion":[108],"individuals":[110],"die":[112],"before":[113],"expressing":[114],"trait),":[116],"which":[117],"typically":[119],"unmeasured":[120],"correlative":[122],"studies.":[123],"Chapter":[124,143,228],"1":[125],"demonstrates":[126],"viability":[128],"prior":[130],"trait":[132],"expression":[133],"can":[134,164],"change":[135],"direction":[137],"magnitude":[139],"selection.":[141],"2,":[144],"identified":[146],"fitness":[147,253],"trade-offs":[148],"(viability":[149],"fecundity)":[151],"varying":[153],"at":[155],"spatial":[157,204],"temporal":[159],"scale":[160,205],"effect":[167],"Using":[174],"NILs":[175],"(Nearly":[176],"Isogenic":[177],"Lines),":[178],"demonstrate":[180],"alleles":[182],"increasing":[183],"also":[186,195],"increase":[187],"fecundity":[188],"but":[189],"they":[190],"survivorship.":[192],"Furthermore,":[193],"detected":[196],"fluctuating":[197],"by":[199],"year":[200],"meters.":[207],"Finally,":[208],"correlated":[209],"corolla":[212,237],"width":[213,238],"limit":[215],"response":[218],"for":[222],"size.":[224],"demonstrated":[226],"3":[229],"multi-year":[232],"manipulation":[234],"experiment":[235],"under":[240],"indirect":[241],"due":[243],"its":[245],"correlation":[247],"other":[249],"influence":[252],"(e.g.":[257],"rate":[258],"development,":[260],"reproductive":[261],"capacity,":[262],"vegetative":[263],"size).":[264]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}