{"id":"https://openalex.org/W797373000","doi":"https://doi.org/10.5287/ora-5j5byxbrv","title":"A study of surface receptors on rat T lymphocytes","display_name":"A study of surface receptors on rat T lymphocytes","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W797373000","doi":"https://doi.org/10.5287/ora-5j5byxbrv","mag":"797373000"},"language":"en","primary_location":{"id":"pmh:hdl:10068/587561","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/587561","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/587561","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073019077","display_name":"Glenn Crocker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Crocker, Glenn.","raw_affiliation_strings":["University of Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113678081","display_name":"Barry Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin, Barry.","raw_affiliation_strings":["University of Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Newton, Mary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Newton, Mary","raw_affiliation_strings":["University of Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":null,"display_name":"Crocker, Glenn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crocker, Glenn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antibody-cross-linking","display_name":"antibody cross-linking","score":0.7699999809265137},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.745871901512146},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6220004558563232},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.5657943487167358},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5501164793968201},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5240830779075623},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5221148729324341},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4975643455982208},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.46457821130752563},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4540870189666748},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4346325993537903},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4198644459247589},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.4117076098918915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36850666999816895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19515690207481384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18611425161361694},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12950396537780762}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/587561","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/587561","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"doi:10.5287/ora-5j5byxbrv","doi":"https://doi.org/10.5287/ora-5j5byxbrv","is_oa":true,"landing_page_url":"https://doi.org/10.5287/ora-5j5byxbrv","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:797373000","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302893","pdf_url":null,"source":{"id":"https://openalex.org/S4306508408","display_name":"Dr Leonard Polonsky thesis digitisation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Dr Leonard Polonsky thesis digitisation","raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/587561","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/587561","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037327557","https://openalex.org/W2117720305","https://openalex.org/W1655766951","https://openalex.org/W2156806142","https://openalex.org/W7098595101","https://openalex.org/W1973598651","https://openalex.org/W2055353455","https://openalex.org/W2159431877","https://openalex.org/W2037621250","https://openalex.org/W2163855820"],"abstract_inverted_index":{"A":[0,117],"double":[1],"immunolabelling":[2],"technique":[3],"was":[4,33,119],"developed":[5],"to":[6,101,121,144,162],"study":[7,102],"microscopically":[8],"the":[9,15,20,28,43,50,65,80,89,103,127,156,170,175],"interactions":[10],"between":[11,123],"CD4,":[12,59],"CD45":[13,39,55,77],"and":[14,38,54,73,114,126,135,172],"T":[16,24,46,51,66,81,90,111,145],"cell":[17,47,52,67,82,91,112,146,160],"receptor":[18,53,68,83,92,124],"on":[19,110,133],"surface":[21,165],"of":[22,30,76,105,129,140,158,174],"rat":[23],"cells":[25],"induced":[26],"by":[27],"phenomenon":[29,176],"co-capping.":[31,96],"It":[32],"found":[34,120],"that":[35,49,61],"both":[36],"CD4":[37,63,85,87],"passively":[40,56,95],"co-cap":[41,57,69],"with":[42,58,70,78,142],"actively":[44],"capped":[45],"receptor,":[48],"but":[60],"neither":[62],"nor":[64],"CD45.":[71],"Co-crosslinking":[72],"active":[74],"capping":[75],"either":[79],"or":[84,88],"prevented":[86],"respectively,":[93],"from":[94],"These":[97],"experiments":[98],"were":[99],"extended":[100],"effects":[104,128],"particular":[106,130],"antibody":[107,131],"crosslinking":[108],"conditions":[109],"proliferation":[113,134],"tyrosine":[115,136],"phosphorylation.":[116,137],"correlation":[118],"exist":[122],"distribution":[125],"combinations":[132],"The":[138],"significance":[139],"this":[141],"respect":[143],"activation":[147],"is":[148,153],"discussed.":[149],"Finally,":[150],"an":[151],"observation":[152],"reported":[154],"concerning":[155],"failure":[157],"some":[159],"lines":[161],"cap":[163],"antibody-crosslinked":[164],"molecules.":[166],"Preliminary":[167],"investgations":[168],"into":[169],"nature":[171],"extent":[173],"are":[177],"described.":[178]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}