{"id":"https://openalex.org/W797357684","doi":"https://doi.org/10.1016/j.biologicals.2015.05.006","title":"Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids","display_name":"Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids","publication_year":2015,"publication_date":"2015-06-24","ids":{"openalex":"https://openalex.org/W797357684","doi":"https://doi.org/10.1016/j.biologicals.2015.05.006","mag":"797357684","pmid":"https://pubmed.ncbi.nlm.nih.gov/26115630"},"language":"en","primary_location":{"id":"doi:10.1016/j.biologicals.2015.05.006","doi":"https://doi.org/10.1016/j.biologicals.2015.05.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biologicals.2015.05.006","pdf_url":null,"source":{"id":"https://openalex.org/S110177920","display_name":"Biologicals","issn_l":"1045-1056","issn":["1045-1056","1095-8320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologicals","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108799977","display_name":"Gregory S. Hamilton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory S. Hamilton","raw_affiliation_strings":["Graduate Program in Biotechnology, University of Maryland, Baltimore County, United States. Electronic address: ghamil1@umbc.edu","Graduate Program in Biotechnology, University of Maryland, Baltimore County, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biotechnology, University of Maryland, Baltimore County, United States. Electronic address: ghamil1@umbc.edu","institution_ids":["https://openalex.org/I79272384"]},{"raw_affiliation_string":"Graduate Program in Biotechnology, University of Maryland, Baltimore County, United States","institution_ids":["https://openalex.org/I79272384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108799977"],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.1571,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.77169505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"43","issue":"5","first_page":"318","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":1.0},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cytotoxin","display_name":"cytotoxin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.703000009059906},{"id":"https://openalex.org/keywords/regulatory-challenges","display_name":"regulatory challenges","score":0.925000011920929},{"id":"https://openalex.org/keywords/drug-approval","display_name":"drug approval","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7161203026771545},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7057204246520996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5424843430519104},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.4958733022212982},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48679134249687195},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46590811014175415},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.45408231019973755},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.44080987572669983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39776480197906494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35704126954078674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.110544353723526}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biologicals.2015.05.006","doi":"https://doi.org/10.1016/j.biologicals.2015.05.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biologicals.2015.05.006","pdf_url":null,"source":{"id":"https://openalex.org/S110177920","display_name":"Biologicals","issn_l":"1045-1056","issn":["1045-1056","1095-8320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologicals","raw_type":"journal-article"},{"id":"pmid:26115630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26115630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologicals : journal of the International Association of Biological Standardization","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W47869444","https://openalex.org/W1566701354","https://openalex.org/W1586974265","https://openalex.org/W1964083777","https://openalex.org/W1968590850","https://openalex.org/W1970341069","https://openalex.org/W1971738718","https://openalex.org/W1971741240","https://openalex.org/W1973008689","https://openalex.org/W1975736583","https://openalex.org/W1976147879","https://openalex.org/W1978925562","https://openalex.org/W1979728832","https://openalex.org/W1983267929","https://openalex.org/W1983494459","https://openalex.org/W1984007340","https://openalex.org/W1993122592","https://openalex.org/W2000568282","https://openalex.org/W2014099862","https://openalex.org/W2018295245","https://openalex.org/W2018478612","https://openalex.org/W2021528507","https://openalex.org/W2024812185","https://openalex.org/W2025382759","https://openalex.org/W2028705032","https://openalex.org/W2029750535","https://openalex.org/W2030177226","https://openalex.org/W2034609970","https://openalex.org/W2035118667","https://openalex.org/W2043228552","https://openalex.org/W2043917207","https://openalex.org/W2052768531","https://openalex.org/W2053800409","https://openalex.org/W2058332629","https://openalex.org/W2060537783","https://openalex.org/W2064424529","https://openalex.org/W2064495391","https://openalex.org/W2065303540","https://openalex.org/W2066724170","https://openalex.org/W2068635250","https://openalex.org/W2069915468","https://openalex.org/W2070478879","https://openalex.org/W2073176225","https://openalex.org/W2074443889","https://openalex.org/W2078386415","https://openalex.org/W2079154601","https://openalex.org/W2079700983","https://openalex.org/W2081656524","https://openalex.org/W2083028331","https://openalex.org/W2083982805","https://openalex.org/W2088609615","https://openalex.org/W2090057677","https://openalex.org/W2099808918","https://openalex.org/W2099962215","https://openalex.org/W2101501196","https://openalex.org/W2101893838","https://openalex.org/W2115525058","https://openalex.org/W2118167053","https://openalex.org/W2119423559","https://openalex.org/W2124560587","https://openalex.org/W2125905978","https://openalex.org/W2126855868","https://openalex.org/W2131478662","https://openalex.org/W2132895530","https://openalex.org/W2136166098","https://openalex.org/W2143892831","https://openalex.org/W2144782918","https://openalex.org/W2154020108","https://openalex.org/W2154302491","https://openalex.org/W2155273699","https://openalex.org/W2171227711","https://openalex.org/W2398135296","https://openalex.org/W2407533823","https://openalex.org/W2413998236","https://openalex.org/W2415255830","https://openalex.org/W2417240603","https://openalex.org/W2423910382","https://openalex.org/W2476005205","https://openalex.org/W3147919323"],"related_works":["https://openalex.org/W2998187100","https://openalex.org/W4220847494","https://openalex.org/W7134854917","https://openalex.org/W2810578520","https://openalex.org/W2754547617","https://openalex.org/W3185273357","https://openalex.org/W2921589168","https://openalex.org/W4386026979","https://openalex.org/W3034221570","https://openalex.org/W3208889667"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}