{"id":"https://openalex.org/W795804282","doi":null,"title":"The Molecular Mechanism of Migraine","display_name":"The Molecular Mechanism of Migraine","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W795804282","mag":"795804282"},"language":"en","primary_location":{"id":"pmh:oai:scholarsarchive.byu.edu:etd-4047","doi":null,"is_oa":false,"landing_page_url":"https://scholarsarchive.byu.edu/etd/3048","pdf_url":null,"source":{"id":"https://openalex.org/S4377196308","display_name":"ScholarsArchive  (Brigham Young University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100005738","host_organization_name":"Brigham Young University","host_organization_lineage":["https://openalex.org/I100005738"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008211059","display_name":"Kristin Dawn Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristin Dawn Watson","raw_affiliation_strings":["Brigham Young Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham Young Univ","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008211059"],"corresponding_institution_ids":["https://openalex.org/I100005738"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/migraine-with-aura","display_name":"migraine with aura","score":0.8809999823570251},{"id":"https://openalex.org/keywords/casein-kinase-1-delta","display_name":"CK1\u03b4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/thermal-sensitivity","display_name":"thermal sensitivity","score":0.6200000047683716},{"id":"https://openalex.org/keywords/thermal-nociception","display_name":"thermal nociception","score":0.8349999785423279},{"id":"https://openalex.org/keywords/sex-differences-in-pain","display_name":"sex differences in pain","score":0.7670000195503235},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9350000023841858},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/migraine-pathophysiology","display_name":"migraine pathophysiology","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.919355571269989},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.6103325486183167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.520292341709137},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5037536025047302},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49409177899360657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4526687264442444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33795976638793945},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3286975622177124},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21017345786094666}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarsarchive.byu.edu:etd-4047","doi":null,"is_oa":false,"landing_page_url":"https://scholarsarchive.byu.edu/etd/3048","pdf_url":null,"source":{"id":"https://openalex.org/S4377196308","display_name":"ScholarsArchive  (Brigham Young University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100005738","host_organization_name":"Brigham Young University","host_organization_lineage":["https://openalex.org/I100005738"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},{"id":"mag:795804282","doi":null,"is_oa":false,"landing_page_url":"https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4047&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W194513682","https://openalex.org/W284113109","https://openalex.org/W1557591071","https://openalex.org/W1580583545","https://openalex.org/W1965181820","https://openalex.org/W1965948569","https://openalex.org/W1968050371","https://openalex.org/W1970888849","https://openalex.org/W1970901347","https://openalex.org/W1971335632","https://openalex.org/W1974178115","https://openalex.org/W1974474594","https://openalex.org/W1974495707","https://openalex.org/W1976116451","https://openalex.org/W1978205310","https://openalex.org/W1978466333","https://openalex.org/W1979985299","https://openalex.org/W1980674774","https://openalex.org/W1981198886","https://openalex.org/W1983924090","https://openalex.org/W1985033275","https://openalex.org/W1986359263","https://openalex.org/W1986965597","https://openalex.org/W1992072898","https://openalex.org/W1995790265","https://openalex.org/W1995839968","https://openalex.org/W1998743905","https://openalex.org/W2001114982","https://openalex.org/W2002813375","https://openalex.org/W2005980168","https://openalex.org/W2008022422","https://openalex.org/W2018908697","https://openalex.org/W2022417940","https://openalex.org/W2023731184","https://openalex.org/W2027011181","https://openalex.org/W2030764759","https://openalex.org/W2032666115","https://openalex.org/W2034407873","https://openalex.org/W2035581625","https://openalex.org/W2039145292","https://openalex.org/W2043707484","https://openalex.org/W2045530969","https://openalex.org/W2047455969","https://openalex.org/W2055171682","https://openalex.org/W2056435956","https://openalex.org/W2058262364","https://openalex.org/W2059350861","https://openalex.org/W2062317425","https://openalex.org/W2062761297","https://openalex.org/W2063829584","https://openalex.org/W2066875663","https://openalex.org/W2067648897","https://openalex.org/W2067935544","https://openalex.org/W2069035576","https://openalex.org/W2070215711","https://openalex.org/W2070528905","https://openalex.org/W2073492115","https://openalex.org/W2074465428","https://openalex.org/W2076052507","https://openalex.org/W2078583161","https://openalex.org/W2082358684","https://openalex.org/W2083551700","https://openalex.org/W2083581266","https://openalex.org/W2084197718","https://openalex.org/W2084359213","https://openalex.org/W2089315979","https://openalex.org/W2093312711","https://openalex.org/W2094542138","https://openalex.org/W2095436346","https://openalex.org/W2096108210","https://openalex.org/W2100906560","https://openalex.org/W2101573249","https://openalex.org/W2101631514","https://openalex.org/W2102206508","https://openalex.org/W2107119262","https://openalex.org/W2117402884","https://openalex.org/W2120907839","https://openalex.org/W2122708962","https://openalex.org/W2124796000","https://openalex.org/W2126194551","https://openalex.org/W2132339865","https://openalex.org/W2134338342","https://openalex.org/W2139022372","https://openalex.org/W2147349394","https://openalex.org/W2154791920","https://openalex.org/W2165551982","https://openalex.org/W2329477374","https://openalex.org/W2589075404"],"related_works":["https://openalex.org/W1825109323","https://openalex.org/W4402288564","https://openalex.org/W4307428660","https://openalex.org/W3166456583","https://openalex.org/W1934666791","https://openalex.org/W4311590053","https://openalex.org/W2553151005","https://openalex.org/W4403942734","https://openalex.org/W2041216483","https://openalex.org/W7221761488"],"abstract_inverted_index":{"Migraine":[0],"is":[1,62,170,199,219,250,267,275],"a":[2,104,124,161],"common,":[3],"episodic":[4,34],"neurological":[5],"disorder":[6],"that":[7,73,93,133,217,245,262,293],"includes":[8],"headache,":[9],"nausea":[10],"and":[11,33,43,175,186,193,208,211,281],"hypersensitivity":[12],"to":[13,28,41,52,81,97,148,191,239,299],"sensory":[14],"stimuli.":[15,30],"During":[16],"the":[17,46,114,135,149,180,255],"headache":[18],"phase":[19],"of":[20,36,45,48,151,183,203,235,254,257,265],"migraine,":[21],"migraine":[22,37,49,65,109,174],"patients":[23],"can":[24,291],"be":[25,53],"especially":[26],"hypersensitive":[27],"thermal":[29,82,98,181,197,222,240,259,271,286,301],"The":[31],"unpredictable":[32],"nature":[35],"makes":[38],"it":[39],"difficult":[40],"treat":[42],"much":[44],"mechanism":[47],"has":[50],"yet":[51],"elucidated.":[54],"A":[55,68],"T44A":[56],"substitution":[57],"in":[58,107,128,131,139,172,205,224,278,303],"casein":[59],"kinase":[60],"1\u03b4":[61],"inherited":[63],"with":[64,66,75,86,102,113,230],"aura.":[67],"transgenic":[69],"mouse":[70],"model":[71],"suggests":[72,244],"animals":[74,112,132,144,234],"this":[76],"mutation":[77,116],"exhibit":[78],"increased":[79],"sensitivity":[80,130,182,198,260,287,302],"stimuli":[83,241],"after":[84,100,228],"injection":[85,101,204,229],"nitroglycerin":[87],"(NTG).":[88],"We":[89],"performed":[90],"behavior":[91],"assays":[92],"measure":[94],"animal":[95],"responses":[96],"stimuli,":[99],"NTG,":[103,233],"known":[105],"migraine-inducer":[106],"human":[108],"patients.":[110],"Female":[111,142],"CK1\u03b4-T44A":[115,136,143,157,194,279,282,294],"are":[117,145],"more":[118,146],"sensitive":[119,147],"than":[120,155],"wildtype":[121,140,192,285],"littermates,":[122],"suggesting":[123],"sex":[125,163],"difference":[126],"emerges":[127],"pain":[129,154,166,176],"express":[134],"but":[137],"not":[138,252,296],"siblings.":[141],"effects":[150],"NTG":[152],"on":[153],"male":[156,207],"mice.":[158,195,214,226],"This":[159,215,243],"indicates":[160],"potential":[162],"hormone":[164],"related":[165],"response.":[167],"Since":[168,273],"estrogen":[169,246],"implicated":[171],"both":[173,206],"response,":[177],"we":[178,290],"test":[179],"heterozygous":[184],"ER\u03b2KO/+":[185,188,210,213],"CK1\u03b4-T44A;":[187],"mice":[189,280,283],"compared":[190],"Overall":[196],"decreased":[200],"before":[201],"stress":[202],"female":[209],"CK1\u03b4-T44A:":[212],"demonstrates":[216],"ER\u03b2":[218,249,266,274,298],"necessary":[220],"for":[221,269],"nociception":[223],"untreated":[225,304],"However,":[227],"saline":[231],"or":[232,261],"all":[236],"genotypes":[237],"responded":[238],"similarly.":[242],"signaling":[247],"through":[248],"likely":[251],"part":[253],"pathway":[256],"NTG-induced":[258,270],"one":[263],"copy":[264],"sufficient":[268],"sensitivity.":[272],"fully":[276],"functional":[277],"have":[284],"at":[288],"baseline,":[289],"conclude":[292],"does":[295],"modulate":[297],"affect":[300],"animals.":[305]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
