{"id":"https://openalex.org/W79514353","doi":null,"title":"Central nervous system neuronal surface antibody-associated syndromes. Clinical and Laboratory Characterization","display_name":"Central nervous system neuronal surface antibody-associated syndromes. Clinical and Laboratory Characterization","publication_year":2012,"publication_date":"2012-01-26","ids":{"openalex":"https://openalex.org/W79514353","mag":"79514353"},"language":"en","primary_location":{"id":"pmh:oai:www.research.unipd.it:11577/3422468","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3422468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11577/3422468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011786587","display_name":"Luigi Zuliani","orcid":"https://orcid.org/0000-0001-7922-9024","observed_orcids":["https://orcid.org/0000-0001-7922-9024"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zuliani, Luigi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011786587"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-surface-antibodies","display_name":"neuronal surface antibodies","score":0.9480000138282776},{"id":"https://openalex.org/keywords/autoimmune-encephalitis","display_name":"autoimmune encephalitis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/anti-nmda-receptor-antibodies","display_name":"NMDA receptor antibodies","score":0.9800000190734863},{"id":"https://openalex.org/keywords/autoimmune-cerebellar-ataxia","display_name":"autoimmune cerebellar ataxia","score":0.7310000061988831},{"id":"https://openalex.org/keywords/autoimmune-epilepsy","display_name":"autoimmune epilepsy","score":0.3700000047683716},{"id":"https://openalex.org/keywords/autoimmune-psychosis","display_name":"autoimmune psychosis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/autoantibody-testing","display_name":"autoantibody detection","score":0.7260000109672546},{"id":"https://openalex.org/keywords/immunofluorescence","display_name":"immunofluorescence","score":0.6510000228881836},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.621999979019165},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"mass spectrometry","score":0.7139999866485596},{"id":"https://openalex.org/keywords/immunoprecipitation","display_name":"immunoprecipitation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/paraneoplastic-syndrome","display_name":"paraneoplastic syndrome","score":0.6679999828338623},{"id":"https://openalex.org/keywords/t-cell-mediated-autoimmunity","display_name":"T cell-mediated autoimmunity","score":0.6019999980926514},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.5389999747276306},{"id":"https://openalex.org/keywords/cerebellar-ataxia","display_name":"cerebellar ataxia","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6399067640304565},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5108087062835693},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.4797852635383606},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4441722631454468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40147536993026733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3193746507167816},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29500874876976013}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.research.unipd.it:11577/3422468","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3422468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:www.research.unipd.it:11577/3422468","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3422468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W1846386722","https://openalex.org/W1964236023","https://openalex.org/W1964507380","https://openalex.org/W1966320009","https://openalex.org/W1966536407","https://openalex.org/W1968374987","https://openalex.org/W1970564212","https://openalex.org/W1977295000","https://openalex.org/W1980716663","https://openalex.org/W1981329070","https://openalex.org/W1983883744","https://openalex.org/W1986756933","https://openalex.org/W1988791276","https://openalex.org/W1991366673","https://openalex.org/W1994359855","https://openalex.org/W1996510251","https://openalex.org/W1997450203","https://openalex.org/W1998057893","https://openalex.org/W1999110121","https://openalex.org/W2001147188","https://openalex.org/W2001694871","https://openalex.org/W2001703389","https://openalex.org/W2001711511","https://openalex.org/W2009224548","https://openalex.org/W2012758059","https://openalex.org/W2020764212","https://openalex.org/W2026492454","https://openalex.org/W2032216603","https://openalex.org/W2034085012","https://openalex.org/W2036106004","https://openalex.org/W2036119752","https://openalex.org/W2037203316","https://openalex.org/W2038748457","https://openalex.org/W2041129046","https://openalex.org/W2042675566","https://openalex.org/W2045623946","https://openalex.org/W2047292678","https://openalex.org/W2048977435","https://openalex.org/W2049026994","https://openalex.org/W2051552021","https://openalex.org/W2055069215","https://openalex.org/W2055500800","https://openalex.org/W2058300653","https://openalex.org/W2061056490","https://openalex.org/W2061821067","https://openalex.org/W2065371727","https://openalex.org/W2068015916","https://openalex.org/W2070577009","https://openalex.org/W2073877537","https://openalex.org/W2076256173","https://openalex.org/W2077429401","https://openalex.org/W2078548944","https://openalex.org/W2078990452","https://openalex.org/W2079188276","https://openalex.org/W2080135076","https://openalex.org/W2085335048","https://openalex.org/W2085476703","https://openalex.org/W2085856553","https://openalex.org/W2087329385","https://openalex.org/W2087363103","https://openalex.org/W2087870869","https://openalex.org/W2088194756","https://openalex.org/W2090379443","https://openalex.org/W2092406095","https://openalex.org/W2093292982","https://openalex.org/W2099917041","https://openalex.org/W2100252544","https://openalex.org/W2107464979","https://openalex.org/W2108621385","https://openalex.org/W2111470622","https://openalex.org/W2114398221","https://openalex.org/W2114935132","https://openalex.org/W2117091873","https://openalex.org/W2118067546","https://openalex.org/W2120455870","https://openalex.org/W2122971055","https://openalex.org/W2123159874","https://openalex.org/W2124472369","https://openalex.org/W2127043216","https://openalex.org/W2130713286","https://openalex.org/W2131446968","https://openalex.org/W2131625303","https://openalex.org/W2134023849","https://openalex.org/W2134389315","https://openalex.org/W2140152000","https://openalex.org/W2140481777","https://openalex.org/W2143285990","https://openalex.org/W2144469764","https://openalex.org/W2145155354","https://openalex.org/W2146199022","https://openalex.org/W2146338073","https://openalex.org/W2147259071","https://openalex.org/W2147528615","https://openalex.org/W2153997637","https://openalex.org/W2159165179","https://openalex.org/W2159289827","https://openalex.org/W2161187043","https://openalex.org/W2161819674","https://openalex.org/W2161973499","https://openalex.org/W2162472632","https://openalex.org/W2165392739","https://openalex.org/W2167036800","https://openalex.org/W2169354261","https://openalex.org/W2169403125","https://openalex.org/W2170121713","https://openalex.org/W2170247488","https://openalex.org/W2323257769","https://openalex.org/W2325494665","https://openalex.org/W2341543030","https://openalex.org/W2460393010","https://openalex.org/W3144847119"],"related_works":["https://openalex.org/W2154980585","https://openalex.org/W3035785411","https://openalex.org/W1572451757","https://openalex.org/W2110278818","https://openalex.org/W2978662557","https://openalex.org/W1527011473","https://openalex.org/W4380760766","https://openalex.org/W2048462503","https://openalex.org/W2320332746","https://openalex.org/W2048977435"],"abstract_inverted_index":{"The":[0,12,122,178,206,248,346,360,447,479,892],"concept":[1],"of":[2,33,84,87,125,144,180,188,204,209,221,234,240,250,276,282,293,304,326,340,348,357,377,380,391,419,430,482,491,494,513,595,690,754,776,842,880,895,911,956,978,1033,1042],"antibody\u2013associated":[3],"central":[4],"nervous":[5],"system":[6],"(CNS)":[7],"disorders":[8],"is":[9,128,363,1011],"relatively":[10],"recent.":[11],"classical":[13],"CNS":[14,46,58,108],"paraneoplastic":[15],"neurological":[16],"syndromes":[17,59,175,381,421,910],"are":[18,57,73,351,1027],"thought":[19,39],"to":[20,65,75,138,154,193,230,320,337,397,405,526,543,561,575,585,612,743,868,904,923,960,1002,1029],"be":[21,76,115,135,139],"T-cell":[22],"mediated,":[23],"and":[24,72,117,141,168,200,246,274,297,328,400,416,440,459,473,488,500,505,538,547,579,618,645,667,680,734,739,773,875,970,1040],"the":[25,31,34,79,97,101,169,181,185,210,215,219,231,235,272,280,302,354,358,369,375,378,392,413,420,428,445,483,486,510,514,517,535,592,691,735,752,771,839,869,878,886,896,954,976,1015,1038],"onconeural":[26],"antibodies":[27,41,62,90,163,166,396,404,523,672,936,959,988],"merely":[28],"biomarkers":[29],"for":[30,279,437,602,632,640,643,648,665,671,695,703,888,933,953,968,1037],"presence":[32],"tumour.":[35],"Accordingly":[36],"it":[37,50],"was":[38,212,746,818,903,966],"that":[40,55,63,107,422,502,521,853,877],"rarely,":[42],"if":[43],"ever,":[44],"caused":[45],"disease.":[47],"Recently,":[48],"however,":[49],"has":[51,191,450,850,1035],"become":[52],"increasingly":[53],"clear":[54],"there":[56,133],"associated":[60,112,171,243,382,394,402,570,731,786,828,845],"with":[61,89,172,244,301,342,383,388,395,403,496,534,545,567,571,582,607,732,737,751,784,796,802,823,829,846,859,863,940,1021],"bind":[64],"cell":[66,406,687],"surface":[67,93,165,286,385,407],"determinants":[68],"on":[69,565,655,684,719,723,808,814],"neuronal":[70,92,164,285,384],"cells":[71,299],"likely":[74],"pathogenic.":[77],"Over":[78],"last":[80],"ten":[81],"years":[82,187],"identification":[83,977,1032],"autoimmune":[85,157,343,498,568,609,843,913],"forms":[86],"encephalitis":[88,242,499,569,610,794],"against":[91,284],"(NS)":[94],"antigens,":[95],"particularly":[96],"VGKC-complex":[98,847],"proteins":[99,532],"or":[100,150,176,1007],"glutamate":[102],"NMDA":[103],"receptor,":[104],"have":[105,155,253,333,373,410,423,434,837,931],"shown":[106,852],"disorders,":[109,147],"often":[110],"without":[111],"tumours,":[113],"can":[114,855],"antibody-mediated":[116],"benefit":[118],"from":[119,196,604,627,759,918,947],"immunomodulatory":[120],"therapies.":[121],"clinical":[123,202,415,487,578,768,840],"spectrum":[124,841],"these":[126,162,251,269,431,439,835],"diseases":[127,170],"not":[129,722,857],"yet":[130,137],"fully":[131],"explored,":[132],"may":[134,152],"others":[136],"discovered,":[140],"some":[142],"types":[143],"more":[145,948],"common":[146],"as":[148,983],"epilepsy":[149],"psychosis,":[151],"prove":[153],"an":[156,777,797,803,889],"basis.":[158],"Here,":[159],"we":[160],"call":[161],"(NSAbs),":[167],"them":[173],"NSAb":[174,323],"NSAS.":[177],"aim":[179,902],"research":[182,564],"performed":[183],"in":[184,268,353,444,507,573,634,710,748,781,820,825,872,908,925,937,975,996,1014,1019],"three":[186,366],"PhD":[189,211],"study":[190,350,900],"been":[192,254,335,425,451,851],"characterize":[194],"NSAS":[195],"both":[197,290],"a":[198,201,315,389,492,583,587,740,755,782,864,899,984,993],"laboratory":[199,217,232,614],"point":[203],"view.":[205],"first":[207,370,944],"year":[208],"spent":[213],"at":[214,311],"Oxford":[216,312,518,919],"under":[218],"supervision":[220],"Prof.":[222,454,463,468],"Angela":[223,455],"Vincent.":[224],"During":[225,591],"this":[226,349,926],"period":[227,512,594],"I":[228,313,372,409,433,503,558,598],"contributed":[229,921],"characterization":[233,490],"two":[236,531],"most":[237,522],"important":[238],"groups":[239],"NSAS:":[241],"VGKC-complex-Abs":[245,501,696,765,813],"NMDAR-Abs.":[247],"results":[249,347,836],"studies":[252,270,930,1026],"published":[255],"(Irani":[256,553],"et":[257,262,554],"al.,":[258,263,555],"Brain":[259,556],"2010a;":[260],"Irani":[261],"2010b).":[264],"My":[265],"personal":[266],"contribution":[267],"included":[271],"development":[273],"optimization":[275],"immunofluorescence":[277,683],"techniques":[278],"detection":[281],"autoantibodies":[283,907],"antigens":[287,399],"(NSAbs)":[288],"using":[289],"primary":[291],"cultures":[292],"rat":[294],"hippocampal":[295,657,686],"neurons":[296],"mammalian":[298],"transfected":[300],"antigen":[303],"interest.":[305],"In":[306,368,833],"addition,":[307],"during":[308,509],"my":[309,563,596],"time":[310],"investigated":[314],"possible":[316,588,912],"novel":[317],"proteomics":[318],"approach":[319],"identify":[321,905],"new":[322,906],"by":[324,453,462,992],"means":[325],"immunoprecipitation":[327,969],"mass":[329,971],"spectrometry.":[330],"These":[331],"experiments":[332],"subsequently":[334],"applied":[336],"screen":[338],"samples":[339,601,626,637,651],"patients":[341,495,566,606,629,693,707,716,726,750,822,939,952],"cerebellar":[344,909,941,961,1044],"syndromes.":[345],"described":[352],"third":[355,893],"part":[356,371,481,894],"thesis.":[359],"doctoral":[361],"thesis":[362,484,897],"divided":[364],"into":[365],"parts.":[367],"reviewed":[374,461,506],"state":[376],"art":[379],"antibodies,":[386],"starting":[387],"comparison":[390],"conditions":[393,443],"intracellular":[398],"those":[401],"antigens.":[408],"then":[411,990],"summarised":[412],"main":[414],"paraclinical":[417],"features":[418],"already":[424],"identified.":[426],"On":[427],"basis":[429],"observations,":[432],"designed":[435],"guidelines":[436,448],"recognizing":[438],"other":[441,736],"immune-mediated":[442],"future.":[446],"work":[449],"supervised":[452],"Vincent":[456],"(Oxford,":[457],"UK)":[458],"critically":[460],"Francesc":[464],"Graus":[465],"(Barcelona,":[466],"Spain),":[467],"Christian":[469],"Bien":[470],"(Bielefeld,":[471],"Germany)":[472],"Dr.":[474,915],"Bruno":[475],"Giometto":[476],"(Treviso,":[477],"Italy).":[478],"second":[480],"describes":[485,898],"immunological":[489,580],"cohort":[493],"suspected":[497,608],"collected":[504],"Padua":[508],"3-year":[511,593],"PhD.":[515],"Recently":[516],"group":[519],"showed":[520],"previously":[524],"attributed":[525],"VGKC":[527],"(by":[528],"radioimmunoprecipitation)":[529],"target":[530],"complexed":[533],"channels":[536],"Lgi1":[537,679],"Caspr2,":[539],"which":[540,973],"also":[541,653,862],"tend":[542],"associate":[544,856],"LE":[546],"Morvan\u2019s":[548,728],"syndrome":[549],"phenotypes,":[550],"respectively":[551],"(see":[552],"2010b)).":[557],"therefore":[559,876],"decided":[560],"focus":[562],"\u2018VGKC\u2019-complex-Abs":[572],"order":[574],"report":[576],"their":[577,711],"profile,":[581],"view":[584],"showing":[586],"antigen-phenotype":[589],"correlation.":[590],"PhD,":[597],"screened":[599,945],"503":[600],"NSAbs":[603],"366":[605],"sent":[611],"our":[613],"between":[615],"January":[616],"2005":[617],"December":[619],"2011:":[620],"279":[621],"serum":[622,957,965],"(and":[623],"cerebrospinal":[624],"fluid)":[625],"232":[628,692],"were":[630,638,652,697,701,717,989],"tested":[631,639,654,694,806],"VGKC-complex-Abs;":[633],"addition":[635],"226":[636],"NMDAR-Abs,":[641],"59":[642],"AMPAR1,2-":[644],"GABAbR-Abs,":[646],"91":[647],"GAD-Abs;":[649],"21":[650],"live":[656,685],"neurons.":[658,962],"Screening":[659],"methods":[660],"included:":[661],"radioimmunoprecipitation":[662],"(RIA)":[663],"assay":[664,670,995],"VGKC-Abs":[666,882],"GAD65-Abs;":[668],"cell-based":[669,994],"binding":[673,955],"human":[674],"NMDAR,":[675],"AMPAR1,":[676],"AMPAR2,":[677],"GABAbR,":[678],"Caspr2;":[681],"indirect":[682],"cultures.":[688],"Thirty-two":[689],"positive.":[698],"Clinical":[699],"data":[700],"available":[702],"18":[704],"patients:":[705],"10":[706],"harboured":[708],"Lgi1-Abs":[709,785,824],"sera,":[712],"3":[713],"Caspr2-Abs,":[714],"5":[715],"positive":[718,790],"RIA":[720],"but":[721,810,861],"IIF.":[724],"Two":[725],"had":[727,792,811],"syndrome,":[729],"one":[730,788,826],"Lgi1-ab":[733],"Caspr2-Ab":[738],"thymoma.":[741],"Response":[742],"immune":[744],"modulation":[745],"reported":[747],"all":[749],"exception":[753],"patient":[756,783,791,801],"who":[757],"died":[758],"lung":[760],"cancer.":[761],"A":[762],"consistently":[763],"high":[764,881],"titre":[766],"despite":[767],"remission":[769],"prompted":[770],"discovery":[772],"subsequent":[774],"removal":[775],"enlarged":[778,890],"hyperplastic":[779,865],"thymus":[780],"LE;":[787],"Caspr2-Abs":[789],"mild":[793],"overlapping":[795],"anti-phospholipid":[798],"syndrome;":[799],"another":[800],"immunotherapy-responsive":[804],"encephalomyelitis":[805],"negative":[807],"IIF":[809],"high-titre":[812],"RIA.":[815],"Striatal":[816],"hypermetabolism":[817],"found":[819,991],"4":[821],"case":[827],"faciobrachial":[830],"dystonic":[831],"seizures.":[832],"conclusion,":[834],"expanded":[838],"encephalopathy":[844],"antibody.":[848],"It":[849],"VGKC-LE":[854],"only":[858,1017],"thymomas,":[860],"thymus,":[866],"similarly":[867],"well-known":[870],"finding":[871],"myasthenia":[873],"gravis":[874],"persistence":[879],"titres":[883],"should":[884],"prompt":[885],"search":[887],"thymus.":[891],"whose":[901],"origin.":[914],"Esther":[916],"Becker":[917],"University":[920],"equally":[922],"me":[924],"work.":[927],"Relatively":[928],"few":[929],"searched":[932],"potentially":[934],"pathogenic":[935],"non-paraneoplastic":[938],"ataxia.":[942,1045],"We":[943],"sera":[946],"52":[949],"idiopathic":[950,1043],"ataxia":[951,999],"IgG":[958],"One":[963],"strong-binding":[964],"selected":[967],"spectrometry,":[972],"resulted":[974],"contactin-associated":[979],"protein":[980],"2":[981],"(Caspr2)":[982],"major":[985],"antigen.":[986],"Caspr2":[987,1010],"9/88":[997],"(10%)":[998],"patients,":[1000],"compared":[1001],"3/144":[1003],"(2%)":[1004],"multiple":[1005],"sclerosis":[1006],"dementia":[1008],"controls.":[1009],"strongly":[1012],"expressed":[1013],"cerebellum,":[1016],"partly":[1018],"association":[1020],"voltage-gated":[1022],"potassium":[1023],"channels.":[1024],"Prospective":[1025],"needed":[1028],"see":[1030],"whether":[1031],"Caspr2-antibodies":[1034],"relevance":[1036],"diagnosis":[1039],"treatment":[1041]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
