{"id":"https://openalex.org/W795131082","doi":"https://doi.org/10.1016/j.ajpath.2013.01.052","title":"Ranibizumab Is a Potential Prophylaxis for Proliferative Vitreoretinopathy, a Nonangiogenic Blinding Disease","display_name":"Ranibizumab Is a Potential Prophylaxis for Proliferative Vitreoretinopathy, a Nonangiogenic Blinding Disease","publication_year":2013,"publication_date":"2013-04-09","ids":{"openalex":"https://openalex.org/W795131082","doi":"https://doi.org/10.1016/j.ajpath.2013.01.052","mag":"795131082","pmid":"https://pubmed.ncbi.nlm.nih.gov/23582767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3644731"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajpath.2013.01.052","doi":"https://doi.org/10.1016/j.ajpath.2013.01.052","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.01.052","pdf_url":"http://ajp.amjpathol.org/article/S0002944013001405/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://ajp.amjpathol.org/article/S0002944013001405/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009830547","display_name":"Steven Pennock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Pennock","raw_affiliation_strings":["The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403319","display_name":"David S. Kim","orcid":"https://orcid.org/0000-0002-4345-661X","observed_orcids":["https://orcid.org/0000-0002-4345-661X"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kim","raw_affiliation_strings":["The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069517897","display_name":"Shizuo Mukai","orcid":"https://orcid.org/0000-0002-0330-0127","observed_orcids":["https://orcid.org/0000-0002-0330-0127"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shizuo Mukai","raw_affiliation_strings":["The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019703391","display_name":"Matthew Kuhnle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Kuhnle","raw_affiliation_strings":["Department of Surgery, Ophthalmology Service, Walter Reed Army Medical Center, Washington, District of Columbia","Walter Reed Army Medical Center, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Ophthalmology Service, Walter Reed Army Medical Center, Washington, District of Columbia","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Walter Reed Army Medical Center, Washington, DC;","institution_ids":["https://openalex.org/I2800363604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062580129","display_name":"Dal W. Chun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dal W. Chun","raw_affiliation_strings":["Department of Surgery, Ophthalmology Service, Walter Reed Army Medical Center, Washington, District of Columbia","Walter Reed Army Medical Center, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Ophthalmology Service, Walter Reed Army Medical Center, Washington, District of Columbia","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Walter Reed Army Medical Center, Washington, DC;","institution_ids":["https://openalex.org/I2800363604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004425555","display_name":"Joanne Aiko Matsubara","orcid":"https://orcid.org/0000-0002-6236-9191","observed_orcids":["https://orcid.org/0000-0002-6236-9191"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joanne Matsubara","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","Univ of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Univ of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075288424","display_name":"Jing Z Cui","orcid":"https://orcid.org/0000-0003-0585-5035","observed_orcids":["https://orcid.org/0000-0003-0585-5035"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jing Cui","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","Univ of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Univ of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110464401","display_name":"Patrick Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick Ma","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","Univ of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Univ of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040261462","display_name":"David Maberley","orcid":"https://orcid.org/0000-0001-6237-1964","observed_orcids":["https://orcid.org/0000-0001-6237-1964"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David Maberley","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","Univ of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Univ of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Arif Samad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Arif Samad","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert J. Van Geest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert J. Van Geest","raw_affiliation_strings":["Medical Retina Unit and Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Retina Unit and Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046470822","display_name":"Sarit Y. Lesnik Oberstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sarit L. Oberstein","raw_affiliation_strings":["Medical Retina Unit and Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Retina Unit and Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059883802","display_name":"Reinier O. Schlingemann","orcid":"https://orcid.org/0000-0002-2300-8289","observed_orcids":["https://orcid.org/0000-0002-2300-8289"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Reinier O. Schlingemann","raw_affiliation_strings":["Medical Retina Unit and Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Retina Unit and Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084984241","display_name":"Andrius Kazlauskas","orcid":"https://orcid.org/0000-0003-1919-3327","observed_orcids":["https://orcid.org/0000-0003-1919-3327"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrius Kazlauskas","raw_affiliation_strings":["The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5084984241"],"corresponding_institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":4.9252,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.94707715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"182","issue":"5","first_page":"1659","last_page":"1670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proliferative-vitreoretinopathy","display_name":"proliferative vitreoretinopathy","score":0.968999981880188},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":1.0},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pdgf-receptor-alpha","display_name":"PDGF receptor alpha","score":0.7120000123977661},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8640000224113464},{"id":"https://openalex.org/keywords/rhegmatogenous-retinal-detachment","display_name":"rhegmatogenous retinal detachment","score":0.9629999995231628},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2771230","wikidata":"https://www.wikidata.org/wiki/Q4926699","display_name":"Blinding","level":3,"score":0.9355756640434265},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.7437286376953125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7092801332473755},{"id":"https://openalex.org/C2779059073","wikidata":"https://www.wikidata.org/wiki/Q7249608","display_name":"Proliferative vitreoretinopathy","level":4,"score":0.6439902782440186},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4986152648925781},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4219134747982025},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.4202050268650055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19256263971328735},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.16620475053787231},{"id":"https://openalex.org/C2780428090","wikidata":"https://www.wikidata.org/wiki/Q625164","display_name":"Retinal detachment","level":3,"score":0.11619231104850769},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.10218486189842224},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.07698372006416321},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018630","descriptor_name":"Vitreoretinopathy, Proliferative","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.ajpath.2013.01.052","doi":"https://doi.org/10.1016/j.ajpath.2013.01.052","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.01.052","pdf_url":"http://ajp.amjpathol.org/article/S0002944013001405/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2981751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3644731","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23582767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23582767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3644731","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3644731/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/288a63be-4fd9-42cf-b3bc-eb1283e2bd7a","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/288a63be-4fd9-42cf-b3bc-eb1283e2bd7a","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pennock, S, Kim, D, Mukai, S, Kuhnle, M, Chun, D W, Matsubara, J, Cui, J, Ma, P, Maberley, D, Samad, A, van Geest, R J, Oberstein, S L, Schlingemann, R O & Kazlauskas, A 2013, 'Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease', American journal of pathology, vol. 182, no. 5, pp. 1659-1670. https://doi.org/10.1016/j.ajpath.2013.01.052","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/41a64fc9-cfb7-4f59-ae0a-35bc3e821c07","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/ranibizumab-is-a-potential-prophylaxis-for-proliferative-vitreoretinopathy-a-nonangiogenic-blinding-disease(41a64fc9-cfb7-4f59-ae0a-35bc3e821c07).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American journal of pathology, 182(5), 1659 - 1670. Elsevier Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:795131082","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2147580","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.ajpath.2013.01.052","doi":"https://doi.org/10.1016/j.ajpath.2013.01.052","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.01.052","pdf_url":"http://ajp.amjpathol.org/article/S0002944013001405/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2445986690","display_name":null,"funder_award_id":"IAO 77736","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2622325423","display_name":"Can FDA-approved agents protect from PVR?","funder_award_id":"R21EY022970","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G456236448","display_name":null,"funder_award_id":"MOP 97806","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5234312226","display_name":"PDGF and PVR","funder_award_id":"R01EY012509","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5896962844","display_name":"Pathogenesis of age-related macular degeneration (AMD)","funder_award_id":"97806_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5956961699","display_name":null,"funder_award_id":"EY012509","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6173909113","display_name":null,"funder_award_id":"WB1XWH-10-1-0392","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000049706","display_name":null,"funder_award_id":"IAO 77736","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309699","display_name":"Massachusetts Eye and Ear","ror":"https://ror.org/04g3dn724"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W795131082.pdf","grobid_xml":"https://content.openalex.org/works/W795131082.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W18482119","https://openalex.org/W19734096","https://openalex.org/W36887661","https://openalex.org/W42912816","https://openalex.org/W46054612","https://openalex.org/W85679339","https://openalex.org/W920510922","https://openalex.org/W1510403526","https://openalex.org/W1536784471","https://openalex.org/W1557755306","https://openalex.org/W1963534846","https://openalex.org/W1970267793","https://openalex.org/W1975552435","https://openalex.org/W1976207005","https://openalex.org/W1985820282","https://openalex.org/W1989408768","https://openalex.org/W1997406077","https://openalex.org/W2002370145","https://openalex.org/W2007895598","https://openalex.org/W2008810667","https://openalex.org/W2014840457","https://openalex.org/W2018817522","https://openalex.org/W2019498844","https://openalex.org/W2024188788","https://openalex.org/W2024542258","https://openalex.org/W2033245558","https://openalex.org/W2035263256","https://openalex.org/W2038127989","https://openalex.org/W2042470405","https://openalex.org/W2055768636","https://openalex.org/W2059267828","https://openalex.org/W2061061470","https://openalex.org/W2065790323","https://openalex.org/W2077040712","https://openalex.org/W2078518488","https://openalex.org/W2081273617","https://openalex.org/W2083728367","https://openalex.org/W2092509198","https://openalex.org/W2092552353","https://openalex.org/W2093718543","https://openalex.org/W2100365433","https://openalex.org/W2101125060","https://openalex.org/W2110143939","https://openalex.org/W2114136101","https://openalex.org/W2114232337","https://openalex.org/W2115778648","https://openalex.org/W2117989312","https://openalex.org/W2124415048","https://openalex.org/W2125363536","https://openalex.org/W2125762952","https://openalex.org/W2126749629","https://openalex.org/W2128017989","https://openalex.org/W2133801172","https://openalex.org/W2133816760","https://openalex.org/W2137260277","https://openalex.org/W2164715245","https://openalex.org/W2165119142","https://openalex.org/W2166156136","https://openalex.org/W2327600805","https://openalex.org/W4206531781","https://openalex.org/W4243068615","https://openalex.org/W4300035639"],"related_works":["https://openalex.org/W2329599548","https://openalex.org/W2008001734","https://openalex.org/W1557755306","https://openalex.org/W1999213916","https://openalex.org/W3030944551","https://openalex.org/W85679339","https://openalex.org/W2297499834","https://openalex.org/W2097213635","https://openalex.org/W116565522","https://openalex.org/W7221785998"],"abstract_inverted_index":{"Proliferative":[0],"vitreoretinopathy":[1],"(PVR)":[2],"exemplifies":[3],"a":[4,28,59],"disease":[5,109],"that":[6,114,120,169,180],"is":[7,99,105],"difficult":[8],"to":[9,26,88,172],"predict,":[10],"lacks":[11],"effective":[12,185],"treatment":[13],"options,":[14],"and":[15,50,77,104,130,135,179,191],"substantially":[16],"reduces":[17],"the":[18,52,83,124,152],"quality":[19],"of":[20,22,35,39,58,64,82,126,144,161],"life":[21],"an":[23,55],"individual.":[24],"Surgery":[25],"correct":[27],"rhegmatogenous":[29],"retinal":[30],"detachment":[31],"fails":[32],"primarily":[33],"because":[34,91],"PVR.":[36],"Likely":[37],"mediators":[38],"PVR":[40,89,103,156],"are":[41,86,175],"growth":[42,65,69,74],"factors":[43,66,75,80],"in":[44,110,155],"vitreous,":[45,157],"which":[46,98],"stimulate":[47],"cells":[48],"within":[49],"behind":[51],"retina":[53],"as":[54],"inevitable":[56],"consequence":[57],"breached":[60],"retina.":[61],"Three":[62],"classes":[63],"[vascular":[67],"endothelial":[68],"factor":[70],"A":[71],"(VEGF-A),":[72],"platelet-derived":[73],"(PDGFs),":[76],"non-PDGFs":[78],"(growth":[79],"outside":[81],"PDGF":[84,95,162],"family)]":[85],"relevant":[87],"pathogenesis":[90],"they":[92],"act":[93],"on":[94],"receptor":[96,163],"\u03b1,":[97],"required":[100],"for":[101,177,186],"experimental":[102,131],"associated":[106],"with":[107,133],"this":[108],"humans.":[111],"We":[112],"discovered":[113],"ranibizumab":[115,145],"(a":[116],"clinically":[117],"approved":[118],"agent":[119],"neutralizes":[121],"VEGF-A)":[122],"reduced":[123],"bioactivity":[125],"vitreous":[127],"from":[128,138],"patients":[129],"animals":[132],"PVR,":[134,178],"protected":[136],"rabbits":[137],"developing":[139],"disease.":[140],"The":[141],"apparent":[142],"mechanism":[143],"action":[146],"involved":[147],"derepressing":[148],"PDGFs,":[149],"which,":[150],"at":[151],"concentrations":[153],"present":[154],"inhibited":[158],"non-PDGF-mediated":[159],"activation":[160],"\u03b1.":[164],"These":[165],"preclinical":[166],"findings":[167],"suggest":[168],"available":[170],"approaches":[171],"neutralize":[173],"VEGF-A":[174],"prophylactic":[176],"anti-VEGF-based":[181],"therapies":[182],"may":[183],"be":[184],"managing":[187],"more":[188],"than":[189],"angiogenesis-":[190],"edema-driven":[192],"pathological":[193],"conditions.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
