{"id":"https://openalex.org/W794643129","doi":null,"title":"Role of nitric oxide in gastroduodenal alkaline secretion.","display_name":"Role of nitric oxide in gastroduodenal alkaline secretion.","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W794643129","mag":"794643129","pmid":"https://pubmed.ncbi.nlm.nih.gov/7727796"},"language":"en","primary_location":{"id":"pmid:7727796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7727796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088820839","display_name":"Jan Bilski","orcid":"https://orcid.org/0000-0002-2699-3798","observed_orcids":["https://orcid.org/0000-0002-2699-3798"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"J Bilski","raw_affiliation_strings":["Institute of Physiology, Jagiellonian University Medical School, Krak\u00f3w, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, Jagiellonian University Medical School, Krak\u00f3w, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109936280","display_name":"Stanislaw Jan Konturek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Konturek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2047,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.48478004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"45","issue":"4","first_page":"541","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.16910000145435333,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/gastric-secretion","display_name":"gastric secretion","score":0.7129999995231628},{"id":"https://openalex.org/keywords/duodenal-secretion","display_name":"duodenal secretion","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.8539999723434448},{"id":"https://openalex.org/keywords/ng-nitro-l-arginine","display_name":"L-NNA","score":0.9710000157356262},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.8889999985694885},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/food-stimulation","display_name":"food stimulation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/prostaglandin-e2-analogue","display_name":"prostaglandin E2 analogue","score":0.7300000190734863},{"id":"https://openalex.org/keywords/heidenhain-pouch","display_name":"Heidenhain pouch","score":0.703000009059906},{"id":"https://openalex.org/keywords/duodenal-loop","display_name":"duodenal loop","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7583326101303101},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7205559015274048},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.6730344891548157},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6680001616477966},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6410239338874817},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5750819444656372},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5417490601539612},{"id":"https://openalex.org/C2777504413","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric acid","level":3,"score":0.5238535404205322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5025851726531982},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.4987032413482666},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.46435168385505676},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.45336323976516724},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.43668538331985474},{"id":"https://openalex.org/C2776809568","wikidata":"https://www.wikidata.org/wiki/Q134955","display_name":"Duodenum","level":2,"score":0.4229975640773773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21693775057792664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19550076127052307},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10974815487861633},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000468","descriptor_name":"Alkalies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008460","descriptor_name":"Meat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011448","descriptor_name":"Prostaglandin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019335","descriptor_name":"Nitroarginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7727796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7727796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:794643129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7727796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983392328","https://openalex.org/W1572140429","https://openalex.org/W1996427591","https://openalex.org/W1598450487","https://openalex.org/W1967005192","https://openalex.org/W1930877453","https://openalex.org/W2301592343","https://openalex.org/W2027143294","https://openalex.org/W333477813","https://openalex.org/W2067251507"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,62,143],"designed":[3],"to":[4,23,85,126,211],"determine":[5],"the":[6,82,111,120,122,128,150,186],"involvement":[7],"of":[8,40,114,124,130,152,159,188,208],"nitric":[9],"oxide":[10],"(NO)":[11],"in":[12,21,28,172,204],"gastric":[13,46,60,174],"and":[14,20,25,34,47,78,136,166,175,214],"duodenal":[15,35,48,56,176],"alkaline":[16,49,57,76,83,101,138,177,206],"under":[17],"basal":[18,74,97,135],"conditions":[19],"response":[22,207],"exogenous":[24],"endogenous":[26,195],"stimulants":[27],"conscious":[29],"dogs":[30],"with":[31,107,155,198],"Heidenhain":[32],"pouches":[33],"loops.":[36],"A":[37,51],"topical":[38],"application":[39,158],"HCl":[41],"or":[42,88,98,190],"capsaicin":[43],"increased":[44],"both":[45,173],"secretion.":[50,118],"meat":[52],"meal":[53],"stimulated":[54,99,137],"only":[55],"secretion":[58,61,77,102,139,178],"while":[59],"not":[63,94,183],"significantly":[64,72,96],"changed.":[65],"The":[66],"NO":[67,153,196],"synthase":[68,154],"inhibitor,":[69],"NG-nitro-L-arginine":[70],"(L-NNA),":[71],"inhibited":[73],"gastroduodenal":[75,100,209],"almost":[79],"completely":[80],"suppressed":[81],"responses":[84,181],"food,":[86],"acid":[87],"capsaicin.":[89,215],"L-arginine":[90],"given":[91,105],"alone":[92],"did":[93],"affect":[95],"but":[103,140,179],"when":[104],"together":[106,197],"L-NNA":[108,115,189],"partially":[109],"reversed":[110],"inhibitory":[112],"effects":[113],"on":[116],"this":[117,141],"For":[119],"comparison,":[121],"administration":[123,187],"indomethacin":[125],"suppress":[127],"generation":[129],"prostaglandin":[131,163],"biosynthesis,":[132],"also":[133],"reduced":[134],"reduction":[142],"relatively":[144],"smaller":[145],"than":[146],"that":[147,194],"attained":[148],"by":[149,185],"inhibition":[151],"L-NNA.":[156],"Luminal":[157],"nocloprost,":[160],"a":[161,201],"stable":[162],"E2":[164],"analog,":[165],"glycerin":[167],"trinitrate":[168],"caused":[169],"significant":[170,202],"increase":[171],"these":[180],"were":[182],"affected":[184],"indomethacin.":[191],"We":[192],"conclude":[193],"prostaglandins":[199],"plays":[200],"role":[203],"secretory":[205],"mucosa":[210],"acid,":[212],"food":[213]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}