{"id":"https://openalex.org/W79463722","doi":null,"title":"Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid.","display_name":"Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid.","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W79463722","mag":"79463722","pmid":"https://pubmed.ncbi.nlm.nih.gov/9058659"},"language":"en","primary_location":{"id":"pmid:9058659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9058659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019040341","display_name":"Gerald Partsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799334681","display_name":"Ludwig Boltzmann Gesellschaft","ror":"https://ror.org/01v1jam04","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G Partsch","raw_affiliation_strings":["Ludwig Boltzmann Institute of Rheumatology, Vienna-Oberlaa, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Boltzmann Institute of Rheumatology, Vienna-Oberlaa, Austria","institution_ids":["https://openalex.org/I2799334681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086709802","display_name":"G.E. Steiner","orcid":"https://orcid.org/0000-0002-5089-7405","observed_orcids":["https://orcid.org/0000-0002-5089-7405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Steiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039707053","display_name":"B.F. Leeb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B F Leeb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071470000","display_name":"Attila Dunky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Dunky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043255698","display_name":"H Br\u00f6ll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Br\u00f6ll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109075339","display_name":"J S Smolen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Smolen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1738,"has_fulltext":false,"cited_by_count":295,"citation_normalized_percentile":{"value":0.91009146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"24","issue":"3","first_page":"518","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":1.0},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8519999980926514},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.984000027179718},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/joint-damage","display_name":"joint destruction","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cytokine-profile","display_name":"cytokine profile","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.9500359892845154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9135968685150146},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.8041461706161499},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7545236349105835},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.7119948267936707},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.6527121663093567},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5088332295417786},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5080540180206299},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5040170550346375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4789622128009796},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.4615059196949005},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.43746018409729004},{"id":"https://openalex.org/C2776821229","wikidata":"https://www.wikidata.org/wiki/Q16965166","display_name":"Inflammatory arthritis","level":3,"score":0.4149308204650879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4109504222869873},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.34808140993118286},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2860257029533386},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23436373472213745},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9058659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9058659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:79463722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9058659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2136910895","https://openalex.org/W2397530324","https://openalex.org/W2101005621","https://openalex.org/W1221104476","https://openalex.org/W3043974903","https://openalex.org/W4381550305","https://openalex.org/W60883445","https://openalex.org/W2042136358","https://openalex.org/W2139619280","https://openalex.org/W2332947543"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,14,17,82],"potential":[4],"role":[5],"of":[6,16,24,37,56,91,103,105],"cytokines":[7,19,107],"in":[8,20,26,50,64,68,74,81,97,109,115,125,134],"psoriatic":[9],"arthritis":[10,30],"(PsA)":[11],"by":[12],"assessing":[13],"profiles":[15],"proinflammatory":[18,106],"synovial":[21],"fluid":[22],"(SF)":[23],"PsA":[25,65,86,110,118],"comparison":[27],"with":[28],"rheumatoid":[29],"(RA)":[31],"and":[32,46,59,87,128],"osteoarthritis":[33],"(OA).":[34],"METHODS:":[35],"Levels":[36,55],"tumor":[38],"necrosis":[39],"factor-alpha":[40],"(TNF-alpha),":[41],"interleukin":[42],"1":[43],"(IL-1),":[44],"IL-6,":[45],"IL-8":[47,60],"were":[48,61,93],"measured":[49],"SF":[51,66],"using":[52],"ELISA.":[53],"RESULTS:":[54],"TNF-alpha,":[57],"IL-1beta,":[58],"significantly":[62],"higher":[63,95],"than":[67,73,96],"OA":[69,98],"SF,":[70,89],"although":[71],"lower":[72],"RA":[75,88],"SF.":[76,99],"No":[77],"difference":[78],"was":[79],"detected":[80],"IL-6":[83],"levels":[84],"between":[85],"both":[90],"which":[92],"much":[94],"CONCLUSION:":[100],"The":[101],"pattern":[102],"expression":[104],"seen":[108],"is":[111,119],"similar":[112],"to":[113],"that":[114],"RA.":[116],"Since":[117],"also":[120],"a":[121],"destructive":[122],"arthropathy,":[123],"cytokines,":[124],"particular":[126],"TNF-alpha":[127],"IL-1,":[129],"may":[130],"be":[131],"principle":[132],"factors":[133],"joint":[135],"destruction.":[136]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
