{"id":"https://openalex.org/W793797976","doi":null,"title":"Low Fluid Shear Culture of Staphylococcus Aureus Represses hfq Expression and Induces an Attachment-Independent Biofilm Phenotype","display_name":"Low Fluid Shear Culture of Staphylococcus Aureus Represses hfq Expression and Induces an Attachment-Independent Biofilm Phenotype","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W793797976","mag":"793797976"},"language":"en","primary_location":{"id":"mag:793797976","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20110005529/downloads/20110005529.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090243555","display_name":"Charlie Mark Ott","orcid":"https://orcid.org/0000-0002-3101-4806","observed_orcids":["https://orcid.org/0000-0002-3101-4806"]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Mark Ott","raw_affiliation_strings":["NASA Johnson Space Center Houston, TX, United States"],"raw_orcid":"https://orcid.org/0000-0002-3101-4806","affiliations":[{"raw_affiliation_string":"NASA Johnson Space Center Houston, TX, United States","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066456098","display_name":"Sarah\u00ed Luna\u2010Castro","orcid":"https://orcid.org/0000-0002-9193-8605","observed_orcids":["https://orcid.org/0000-0002-9193-8605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah\u00ed Luna\u2010Castro","raw_affiliation_strings":["Texas Univ. Medical Branch Houston, TX, United States"],"raw_orcid":"https://orcid.org/0000-0002-9193-8605","affiliations":[{"raw_affiliation_string":"Texas Univ. Medical Branch Houston, TX, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012748720","display_name":"Cheryl A. Nickerson","orcid":"https://orcid.org/0000-0002-9804-9739","observed_orcids":["https://orcid.org/0000-0002-9804-9739"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl A. Nickerson","raw_affiliation_strings":["Arizona State Univ. AZ, United States"],"raw_orcid":"https://orcid.org/0000-0002-9804-9739","affiliations":[{"raw_affiliation_string":"Arizona State Univ. AZ, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091346776","display_name":"Mayra A. Nelman-Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144472018","display_name":"Wyle (United States)","ror":"https://ror.org/02zeryz43","country_code":"US","type":"company","lineage":["https://openalex.org/I144472018","https://openalex.org/I153156064"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayra Nelman\u2010Gonzalez","raw_affiliation_strings":["Wyle Labs., Inc. Houston, TX United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyle Labs., Inc. Houston, TX United States","institution_ids":["https://openalex.org/I144472018"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03711117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.8140000104904175},{"id":"https://openalex.org/keywords/rotating-wall-vessel-bioreactor","display_name":"rotating wall vessel bioreactor","score":0.7799999713897705},{"id":"https://openalex.org/keywords/bacterial-aggregates","display_name":"bacterial aggregates","score":0.6140000224113464},{"id":"https://openalex.org/keywords/extracellular-polymeric-substances","display_name":"extracellular polymeric substances","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9449999928474426},{"id":"https://openalex.org/keywords/carotenoid-production","display_name":"carotenoid production","score":0.9269999861717224},{"id":"https://openalex.org/keywords/oxidative-stress-susceptibility","display_name":"oxidative stress susceptibility","score":0.8709999918937683},{"id":"https://openalex.org/keywords/virulence-gene-regulation","display_name":"virulence gene regulation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/mechanical-stress-response","display_name":"mechanical stress response","score":0.628000020980835},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8355644941329956},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8047289252281189},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8046107888221741},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6747486591339111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5270307660102844},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4937301576137543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2560189962387085},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07445082068443298}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:793797976","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20110005529/downloads/20110005529.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115380923","https://openalex.org/W2115390850","https://openalex.org/W6922307328","https://openalex.org/W1521812393","https://openalex.org/W6940918545","https://openalex.org/W2253889504","https://openalex.org/W6903453662","https://openalex.org/W2156106908","https://openalex.org/W4416755030","https://openalex.org/W7125120587"],"abstract_inverted_index":{"Background:":[0],"The":[1,42,75,174],"opportunistic":[2],"pathogen,":[3],"Staphylococcus":[4],"aureus,":[5,232],"experiences":[6],"fluctuations":[7],"in":[8,28,80,121,129,150,181,191,205,212,230,233,240],"fluid":[9,40,49,72,217],"shear":[10,50,73,218],"during":[11],"infection":[12],"and":[13,94,112,159,169],"colonization":[14,210],"of":[15,39,44,132,207,223],"a":[16,68,208,215],"human":[17],"host.":[18],"Colonization":[19],"frequently":[20],"occurs":[21],"at":[22],"mucus":[23],"membrane":[24],"sites":[25],"such":[26],"as":[27,88,90],"the":[29,33,81,102,122,151,221,236],"gastrointestinal":[30],"tract":[31],"where":[32],"bacterium":[34],"may":[35],"experience":[36],"low":[37,48,71,216],"levels":[38],"shear.":[41],"response":[43,213,226,249],"S.":[45,54,105,118,154,192,200,231],"aureus":[46,55,106,119,155,201],"to":[47,58,166,188,214,227,235,250],"remains":[51],"unclear.":[52],"Methods:":[53],"was":[56,156,185],"cultured":[57,104,153],"stationary":[59],"phase":[60],"using":[61],"Rotating-Wall":[62],"Vessel":[63],"(RWV)":[64],"bioreactors":[65],"which":[66],"produce":[67],"physiologically":[69],"relevant":[70],"environment.":[74,219],"bacterial":[76],"aggregates":[77,126,139],"that":[78,199],"developed":[79],"RWV":[82],"were":[83,107],"evaluated":[84],"by":[85,109,171],"electron":[86],"microscopy":[87],"well":[89],"for":[91,101],"antibiotic":[92,142],"resistance":[93,143],"other":[95],"virulence-associated":[96],"stressors.":[97],"Genetic":[98],"expression":[99],"profiles":[100],"low-shear":[103,123,152,179,228],"determined":[108],"microarray":[110],"analysis":[111],"quantitative":[113],"real-time":[114],"PCR.":[115],"Results:":[116],"Planktonic":[117],"cultures":[120,161],"environment":[124],"formed":[125],"completely":[127],"encased":[128],"high":[130],"amounts":[131],"extracellular":[133],"polymeric":[134],"substances.":[135],"In":[136],"addition,":[137],"these":[138,160],"demonstrated":[140],"increased":[141,164],"indicating":[144],"attachment-independent":[145],"biofilm":[146],"formation.":[147],"Carotenoid":[148],"production":[149],"significantly":[157],"decreased,":[158],"displayed":[162],"an":[163,224,246],"susceptibility":[165],"oxidative":[167],"stress":[168],"killing":[170],"whole":[172],"blood.":[173],"hfq":[175],"gene,":[176],"associated":[177],"with":[178],"growth":[180],"Gram":[182,241],"negative":[183,242],"organisms,":[184,243],"also":[186],"found":[187],"be":[189],"down-regulated":[190],"aureus.":[193],"Conclusions:":[194],"Collectively,":[195],"this":[196],"data":[197],"suggests":[198,245],"decreases":[202],"virulence":[203],"characteristics":[204],"favor":[206],"biofilm-dwelling":[209],"phenotype":[211],"Furthermore,":[220],"identification":[222],"Hfq":[225],"culture":[229],"addition":[234],"previously":[237],"reported":[238],"responses":[239],"strongly":[244],"evolutionarily":[247],"conserved":[248],"mechanical":[251],"stimuli":[252],"among":[253],"structurally":[254],"diverse":[255],"prokaryotes.":[256]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
