{"id":"https://openalex.org/W79377702","doi":"https://doi.org/10.1385/1-59745-003-0:359","title":"Statistical Issues in Microarray Data Analysis","display_name":"Statistical Issues in Microarray Data Analysis","publication_year":2006,"publication_date":"2006-09-07","ids":{"openalex":"https://openalex.org/W79377702","doi":"https://doi.org/10.1385/1-59745-003-0:359","mag":"79377702","pmid":"https://pubmed.ncbi.nlm.nih.gov/16739591"},"language":"en","primary_location":{"id":"doi:10.1385/1-59745-003-0:359","doi":"https://doi.org/10.1385/1-59745-003-0:359","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59745-003-0:359","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabidopsis Protocols","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4246923112","display_name":"Arabidopsis Protocols"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066330177","display_name":"Willem Albert Rensink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Willem A. Rensink","raw_affiliation_strings":["The Institute for Genomic Research, Rockville, MD, USA","The Institute for Genomic Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Genomic Research, Rockville, MD, USA","institution_ids":[]},{"raw_affiliation_string":"The Institute for Genomic Research","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089920583","display_name":"Samuel P. Hazen","orcid":"https://orcid.org/0000-0001-9131-8994","observed_orcids":["https://orcid.org/0000-0001-9131-8994"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel P. Hazen","raw_affiliation_strings":["The Scripps Research Institute, La Jolla","THE SCRIPPS RESEARCH INSTITUTE;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, La Jolla","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"THE SCRIPPS RESEARCH INSTITUTE;","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.4051,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.99359055,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"323","issue":null,"first_page":"359","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microarray-analysis","display_name":"microarray data analysis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.5590000152587891},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gene-expression-data","display_name":"gene expression data","score":0.5759999752044678},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6050000190734863},{"id":"https://openalex.org/keywords/plant-experiments","display_name":"plant experiments","score":0.6489999890327454},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.637629508972168},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.606856644153595},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5903807282447815},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4977912902832031},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4883729815483093},{"id":"https://openalex.org/C548314002","wikidata":"https://www.wikidata.org/wiki/Q6839218","display_name":"Microarray databases","level":5,"score":0.4258395731449127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1948835551738739},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1419873833656311},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10740509629249573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08953791856765747},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1385/1-59745-003-0:359","doi":"https://doi.org/10.1385/1-59745-003-0:359","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59745-003-0:359","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabidopsis Protocols","raw_type":"book-chapter"},{"id":"pmid:16739591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16739591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1495359568","https://openalex.org/W1499375494","https://openalex.org/W1995815904","https://openalex.org/W2002810210","https://openalex.org/W2038437697","https://openalex.org/W2053818267","https://openalex.org/W2060406328","https://openalex.org/W2063862573","https://openalex.org/W2076960545","https://openalex.org/W2093017030","https://openalex.org/W2096758922","https://openalex.org/W2100668965","https://openalex.org/W2109619915","https://openalex.org/W2109972881","https://openalex.org/W2110065044","https://openalex.org/W2119274294","https://openalex.org/W2120865735","https://openalex.org/W2131456395","https://openalex.org/W2133111499","https://openalex.org/W2133210805","https://openalex.org/W2135187880","https://openalex.org/W2137784044","https://openalex.org/W2150926065","https://openalex.org/W2157795344"],"related_works":["https://openalex.org/W2069890079","https://openalex.org/W2079012439","https://openalex.org/W143843685","https://openalex.org/W2140020637","https://openalex.org/W2410771673","https://openalex.org/W1965843937","https://openalex.org/W2396211705","https://openalex.org/W1556472699","https://openalex.org/W2056932428","https://openalex.org/W1576272647"],"abstract_inverted_index":{"Microarrays":[0],"provide":[1,147,161],"the":[2,7,28,56,60,64,68,71,80,83,172],"ability":[3],"to":[4,16,55,119,134,146,160],"quantitatively":[5],"measure":[6],"abundance":[8],"of":[9,20,26,50,70,89,108,116,127,166],"specific":[10],"RNA":[11],"transcripts":[12],"through":[13],"sample":[14],"hybridization":[15],"a":[17,148,153,162],"solid-state":[18],"grid":[19],"oligonucleotides":[21],"or":[22,152],"amplicons.":[23],"The":[24,48],"prospect":[25],"measuring":[27],"entire":[29],"transcriptome":[30],"is":[31,66,142,157],"extremely":[32],"alluring,":[33],"but":[34],"as":[35],"with":[36,43],"any":[37],"experiment,":[38],"it":[39,141],"should":[40],"be":[41],"met":[42],"caution":[44],"and":[45,74,111,113,124,140,170],"great":[46],"consideration.":[47],"level":[49],"confidence":[51],"we":[52],"can":[53],"assign":[54],"results":[57],"depends":[58],"on":[59],"skill":[61],"at":[62],"which":[63,104],"experiment":[65,87],"conducted,":[67],"quality":[69],"experimental":[72],"design":[73],"subsequent":[75],"analysis,":[76],"and,":[77],"most":[78],"important,":[79],"power":[81],"in":[82,136],"study.":[84],"Any":[85],"microarray":[86],"consists":[88],"several":[90,106],"components:":[91],"(1)":[92],"carrying":[93],"out":[94],"an":[95],"appropriately":[96],"designed":[97],"(replicated)":[98],"plant":[99],"experiment;":[100],"(2)":[101],"array":[102],"processing,":[103],"includes":[105],"steps":[107,139],"data":[109,118],"acquisition":[110],"normalization;":[112],"(3)":[114],"analysis":[115],"expression":[117],"identify":[120],"differentially":[121],"expressed":[122],"genes":[123],"overall":[125],"patterns":[126],"expression.":[128],"Numerous":[129],"software":[130,149],"packages":[131],"are":[132],"available":[133],"assist":[135],"performing":[137],"these":[138,167],"not":[143],"our":[144,158],"intent":[145,159],"users":[150],"manual":[151],"statistical":[154],"review.":[155],"It":[156],"brief":[163],"user's":[164],"explanation":[165],"various":[168],"components":[169],"present":[171],"commonly":[173],"used":[174],"methods.":[175]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}