{"id":"https://openalex.org/W793758956","doi":null,"title":"Investigating Interactions of the PKC\u03b1 C1B Domain with Lipid Bilayers and Activators: An EPR Site-Directed Spin-Labeling and Relaxation Study","display_name":"Investigating Interactions of the PKC\u03b1 C1B Domain with Lipid Bilayers and Activators: An EPR Site-Directed Spin-Labeling and Relaxation Study","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W793758956","mag":"793758956"},"language":"en","primary_location":{"id":"pmh:oai:cuscholar:k643b1720","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/k643b1720","pdf_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/k643b1720","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/k643b1720","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"I. M. MILLER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"I. M. MILLER","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12381","display_name":"Electron Spin Resonance Studies","score":0.18129999935626984,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.8510000109672546},{"id":"https://openalex.org/keywords/c1b-domain","display_name":"C1B domain","score":0.9829999804496765},{"id":"https://openalex.org/keywords/protein-membrane-interactions","display_name":"protein-membrane interactions","score":0.6589999794960022},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.8109999895095825},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9490000009536743},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pma","display_name":"PMA","score":0.7409999966621399},{"id":"https://openalex.org/keywords/power-saturation","display_name":"power saturation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.5839999914169312},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C177462420","wikidata":"https://www.wikidata.org/wiki/Q7531731","display_name":"Site-directed spin labeling","level":3,"score":0.8396114706993103},{"id":"https://openalex.org/C187961010","wikidata":"https://www.wikidata.org/wiki/Q260463","display_name":"Electron paramagnetic resonance","level":2,"score":0.7516844272613525},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5699489712715149},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5025608539581299},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5021119117736816},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4962177872657776},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.4583636224269867},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3801632523536682},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33021169900894165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30898118019104004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.241914302110672},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.23678413033485413},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19809463620185852},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17027708888053894},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:cuscholar:k643b1720","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/k643b1720","pdf_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/k643b1720","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},{"id":"pmh:oai:scholar.colorado.edu:honr_theses-2118","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/honr_theses/809","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Honors Theses","raw_type":"text"},{"id":"mag:793758956","doi":null,"is_oa":false,"landing_page_url":"http://scholar.colorado.edu/cgi/viewcontent.cgi?article=2118&context=honr_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:cuscholar:k643b1720","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/k643b1720","pdf_url":"https://scholar.colorado.edu/concern/undergraduate_honors_theses/k643b1720","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Undergraduate Honors Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W793758956.pdf","grobid_xml":"https://content.openalex.org/works/W793758956.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1965084076","https://openalex.org/W1971212998","https://openalex.org/W1998349282","https://openalex.org/W2001519509","https://openalex.org/W2010994547","https://openalex.org/W2011685027","https://openalex.org/W2064638211","https://openalex.org/W2081166773","https://openalex.org/W2109046072","https://openalex.org/W2114470810","https://openalex.org/W2160131169","https://openalex.org/W2325515179","https://openalex.org/W2327299273"],"related_works":["https://openalex.org/W2114470810","https://openalex.org/W2327299273","https://openalex.org/W2066919103","https://openalex.org/W2010839464","https://openalex.org/W7009032819","https://openalex.org/W4233767967","https://openalex.org/W1973250430","https://openalex.org/W2559780342","https://openalex.org/W1973432756","https://openalex.org/W7067395171"],"abstract_inverted_index":{"It":[0],"has":[1,51,81],"been":[2,52],"previously":[3,212,229],"shown":[4,82],"that":[5,25,254],"activation":[6,104],"of":[7,14,38,102,133,190,219,295,316,348],"PKC\u03b1":[8,50,67,80,91,174,338],"on":[9,79,105,177,280,300],"the":[10,62,87,90,99,106,114,120,127,130,136,173,186,220,235,281,291,313],"leading":[11,27],"edge":[12,28],"membrane":[13,88,115,168,283,288,325],"a":[15,21,36,95,199,245,257,266,272,341],"polarized":[16],"chemotaxing":[17],"cell":[18,33,59],"contributes":[19],"to":[20,54,86,113,119,125,166,208,226,234,263,278,321,351],"positive":[22],"feedback":[23],"loop":[24],"sustains":[26],"formation":[29],"and":[30,45,61,139,146,160,183,188,195,225,265,339],"facilitates":[31],"eukaryotic":[32],"movement.":[34],"As":[35],"result":[37],"its":[39,117,140],"vital":[40],"role":[41,97,311,343],"in":[42,65,98,185,248,271,312,344],"this":[43,154,296],"process":[44],"other":[46],"known":[47,141,191],"signaling":[48],"pathways,":[49],"studied":[53],"better":[55],"understand":[56],"both":[57],"normal":[58],"function":[60],"various":[63],"diseases":[64],"which":[66],"is":[68,111],"an":[69,309,329],"important":[70,310],"player,":[71],"including":[72,144],"cancer.":[73],"A":[74],"recent":[75],"single":[76],"molecule":[77],"study":[78],"that,":[83],"once":[84],"bound":[85,233,262,277],"bilayer,":[89],"C1B":[92,110,134,175,221,232,255,317],"domain":[93,176,222],"plays":[94,340],"critical":[96],"final":[100],"step":[101],"kinase":[103],"target":[107],"membrane.":[108],"Specifically,":[109],"recruited":[112],"by":[116,223,239],"binding":[118,249],"activating":[121],"lipid":[122,137,142,179,192,237,282],"diacylglycerol":[123],"(DAG)":[124],"activate":[126],"kinase.":[128],"However,":[129],"key":[131],"interactions":[132],"with":[135],"bilayer":[138],"activators":[143,193],"DAG":[145,194,279],"phorbol":[147,200,349],"esters":[148,350],"are":[149],"still":[150],"under":[151],"investigation.":[152],"In":[153],"study,":[155],"EPR":[156],"site-directed":[157],"spin":[158],"labeling":[159],"power":[161],"saturation":[162],"measurements":[163],"were":[164,205],"employed":[165],"determine":[167],"insertion":[169],"depth":[170,203,210,260,269],"values":[171,204,211],"for":[172,231,251,318,335],"simple":[178],"bilayers":[180],"containing":[181],"PC":[182],"PS":[184],"presence":[187],"absence":[189],"PMA":[196,264,319,336],"(the":[197],"latter":[198],"ester).":[201],"These":[202],"then":[206],"compared":[207,320],"protein-to-membrane":[209],"obtained":[213],"through":[214],"molecular":[215],"dynamic":[216],"(MD)":[217],"simulations":[218],"others,":[224],"diffusion":[227],"rates":[228],"measured":[230],"same":[236],"mixtures":[238],"others.":[240],"All":[241],"three":[242],"approaches":[243],"yielded":[244],"common":[246],"trend":[247],"depths":[250,289],"C1B,":[252],"indicating":[253],"adopts":[256],"shallow":[258,304],"docking":[259,268,298],"when":[261,270],"deeper":[267],"membrane-bound,":[273],"activator-free":[274],"state":[275],"or":[276],"bilayer.":[284],"The":[285,303,332],"present":[286],"EPR-determined":[287],"provide":[290],"most":[292],"direct":[293],"measure":[294],"shallower":[297],"geometry":[299,305],"PMA-containing":[301],"membranes.":[302],"may":[306,327],"well":[307,345],"play":[308],"higher":[314,333],"affinity":[315,334],"DAG,":[322],"where":[323],"additional":[324],"penetration":[326],"have":[328],"energetic":[330],"cost.":[331],"superactivates":[337],"central":[342],"established":[346],"ability":[347],"promote":[352],"tumor":[353],"formation.":[354]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
