{"id":"https://openalex.org/W79356774","doi":"https://doi.org/10.1152/ajpheart.1986.251.1.h80","title":"Significance of production of peptide leukotrienes in murine traumatic shock","display_name":"Significance of production of peptide leukotrienes in murine traumatic shock","publication_year":1986,"publication_date":"1986-07-01","ids":{"openalex":"https://openalex.org/W79356774","doi":"https://doi.org/10.1152/ajpheart.1986.251.1.h80","mag":"79356774","pmid":"https://pubmed.ncbi.nlm.nih.gov/3014907"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1986.251.1.h80","doi":"https://doi.org/10.1152/ajpheart.1986.251.1.h80","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1986.251.1.h80","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013920515","display_name":"David V. Craft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. V. Craft","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014186027","display_name":"David J. Lefer","orcid":"https://orcid.org/0000-0003-2293-7278","observed_orcids":["https://orcid.org/0000-0003-2293-7278","https://orcid.org/0009-0006-1025-7004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. J. Lefer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040162739","display_name":"Carl E. Hock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. E. Hock","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. M. Lefer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4698,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.90965092,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"251","issue":"1","first_page":"H80","last_page":"H85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.3962000012397766,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-shock","display_name":"traumatic shock","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bile","display_name":"bile","score":0.574999988079071},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.9210000038146973},{"id":"https://openalex.org/keywords/leukotriene-d4","display_name":"leukotriene D4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leukotriene-e4","display_name":"leukotriene E4","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.8820000290870667},{"id":"https://openalex.org/keywords/endotoxic-shock","display_name":"endotoxic shock","score":0.8240000009536743},{"id":"https://openalex.org/keywords/shock-pathogenesis","display_name":"shock pathogenesis","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8104424476623535},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.7275161147117615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5964035391807556},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5466029644012451},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.46543067693710327},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44053179025650024},{"id":"https://openalex.org/C2778053663","wikidata":"https://www.wikidata.org/wiki/Q2705859","display_name":"Leukotriene E4","level":4,"score":0.4395192265510559},{"id":"https://openalex.org/C2779543280","wikidata":"https://www.wikidata.org/wiki/Q2704310","display_name":"Leukotriene C4","level":4,"score":0.42848700284957886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3916081488132477},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2489437460899353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22366178035736084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2094346284866333},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017999","descriptor_name":"Leukotriene E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1986.251.1.h80","doi":"https://doi.org/10.1152/ajpheart.1986.251.1.h80","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1986.251.1.h80","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:3014907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3014907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2391927382","display_name":null,"funder_award_id":"HL-255-75","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G398284809","display_name":null,"funder_award_id":"HL-06724","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7541135513","display_name":null,"funder_award_id":"HL-07497-06","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987425357","https://openalex.org/W2037022310","https://openalex.org/W2472267894","https://openalex.org/W2463756959","https://openalex.org/W2006864909","https://openalex.org/W2084784404","https://openalex.org/W2078317672","https://openalex.org/W2397941314","https://openalex.org/W2413126774","https://openalex.org/W6961329501"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,153,187,192,199,208,212],"formation":[3],"of":[4,32,128,152,173,198,207,214],"a":[5,23,29,37,46,126,162,166,196,205],"leukotriene":[6,114,168],"metabolite":[7,127,139,154,197],"in":[8,40,48,64,109,143,191,211],"plasma":[9,41],"and":[10,45,68,85,87,100,121,123,169,189],"bile":[11,69,116,193],"during":[12,135],"traumatic":[13,144,215],"shock.":[14,137,216],"Anesthetized":[15],"rats":[16],"subjected":[17],"to":[18,53,125,171],"Noble-Collip":[19],"drum":[20],"trauma":[21],"developed":[22],"lethal":[24],"shock":[25,145],"state":[26],"characterized":[27],"by":[28,73,93,157],"survival":[30],"time":[31],"1.9":[33],"+/-":[34,55,61],"0.3":[35],"h,":[36],"4.5-fold":[38],"increase":[39],"cathepsin":[42],"D":[43],"activity,":[44],"reduction":[47],"mean":[49],"arterial":[50],"blood":[51,188],"pressure":[52],"45":[54],"2":[56],"mmHg":[57,63],"compared":[58,146],"with":[59,95,147,165],"108":[60],"5":[62],"sham-shock":[65],"controls.":[66],"Plasma":[67],"samples":[70],"were":[71,91,107],"analyzed":[72],"reverse-phase":[74],"high-pressure":[75],"liquid":[76],"chromatography":[77],"(HPLC)":[78],"for":[79,177],"peptide":[80,113,167,181,200,209],"leukotrienes":[81,104,182,210],"(e.g.,":[82],"LTC4,":[83],"LTD4,":[84],"LTE4),":[86],"their":[88],"retention":[89],"times":[90],"confirmed":[92,156],"co-elution":[94],"radioactive":[96],"standards,":[97],"radioimmunoassay":[98],"(RIA),":[99],"UV":[101,158],"spectrophotometry.":[102],"No":[103],"or":[105],"metabolites":[106],"found":[108],"plasma.":[110],"The":[111,138,150],"major":[112],"from":[115,186],"was":[117,155],"eluted":[118],"between":[119],"LTC4":[120],"LTD4":[122],"corresponds":[124],"LTE4,":[129],"N-acetyl-LTE4,":[130,195],"which":[131,160],"is":[132],"also":[133],"produced":[134],"endotoxin":[136],"increased":[140],"nearly":[141],"sevenfold":[142],"sham":[148],"trauma.":[149],"identity":[151],"scan,":[159],"revealed":[161],"spectrum":[163],"consistent":[164],"similar":[170],"that":[172],"previously":[174],"reported":[175],"spectra":[176],"N-acetyl-LTE4.":[178],"In":[179],"conclusion,":[180],"are":[183],"rapidly":[184],"cleared":[185],"appear":[190],"as":[194],"leukotrienes.":[201],"These":[202],"findings":[203],"support":[204],"role":[206],"pathogenesis":[213]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}