{"id":"https://openalex.org/W79337569","doi":null,"title":"Dehydroepiandrosterone in systemic lupus erythematosus: relationship between dosage, serum levels, and clinical response.","display_name":"Dehydroepiandrosterone in systemic lupus erythematosus: relationship between dosage, serum levels, and clinical response.","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W79337569","mag":"79337569","pmid":"https://pubmed.ncbi.nlm.nih.gov/9858429"},"language":"en","primary_location":{"id":"pmid:9858429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9858429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"N N Barry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N N Barry","raw_affiliation_strings":["Division of Immunology and Rheumatology, Stanford University Medical Center, CA 94305-5111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, Stanford University Medical Center, CA 94305-5111, USA","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104091366","display_name":"James L. McGuire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L McGuire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012009272","display_name":"Ronald van Vollenhoven","orcid":"https://orcid.org/0000-0001-6438-8663","observed_orcids":["https://orcid.org/0000-0001-6438-8663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R F van Vollenhoven","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3804,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.87539599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"12","first_page":"2352","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.9879999756813049},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/dhea-sulfate","display_name":"DHEA sulfate","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.777999997138977},{"id":"https://openalex.org/keywords/clinical-response","display_name":"clinical response","score":0.6050000190734863},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.625},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9079320430755615},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.8399609923362732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7325365543365479},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.695525050163269},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6208972930908203},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.6011937260627747},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.48174217343330383},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4635116159915924},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.45544883608818054},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4232228994369507},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.41617482900619507},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.3558267056941986},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.26720625162124634},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2622566819190979},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22373348474502563},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17282551527023315},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09306707978248596}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019314","descriptor_name":"Dehydroepiandrosterone Sulfate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9858429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9858429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},{"id":"mag:79337569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9858429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070207717","https://openalex.org/W1995385187","https://openalex.org/W1991211017","https://openalex.org/W2037166637","https://openalex.org/W1652396225","https://openalex.org/W99378873","https://openalex.org/W2117480041","https://openalex.org/W278887632","https://openalex.org/W7097443121","https://openalex.org/W2098593079"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"examine":[2],"in":[3,12,108],"women":[4,39],"with":[5,40,47,121,132,185],"systemic":[6],"lupus":[7,110,186],"erythematosus":[8],"(SLE)":[9],"who":[10],"participated":[11],"a":[13,50],"clinical":[14,32,167,205],"trial":[15],"the":[16,71,122,149],"relationship":[17],"between":[18],"daily":[19],"dose":[20,56,123,174],"of":[21,26,124,140,153,178,194],"dehydroepiandrosterone":[22],"(DHEA),":[23],"serum":[24,141,151,192,199],"levels":[25,94,119,177,200],"DHEA":[27,29,48,116,127,170,179],"and":[28,34,60,86,92,97,117,128,180],"sulfate":[30],"(DHEAS),":[31],"effectiveness,":[33],"side":[35,98,161],"effects.":[36],"METHODS:":[37],"Twenty-three":[38],"mild":[41],"to":[42,169,202],"moderate":[43],"SLE":[44],"were":[45,64,67,95,106],"treated":[46],"for":[49],"6":[51,113],"month":[52],"period.":[53],"The":[54,158,166],"starting":[55],"was":[57,155,163,171],"50":[58],"mg/day,":[59],"monthly":[61,69],"stepwise":[62],"increases":[63],"allowed.":[65],"Subjects":[66],"assessed":[68],"by":[70],"Systemic":[72,78],"Lupus":[73,79],"Erythematosus":[74],"Disease":[75],"Activity":[76,80],"Index,":[77],"Measure":[81],"(SLAM),":[82],"Health":[83],"Assessment":[84],"Questionnaire,":[85],"other":[87],"outcomes.":[88],"Serum":[89,115,126,176],"testosterone,":[90],"DHEA,":[91],"DHEAS":[93,118,129,142,154,181,193],"obtained":[96],"effects":[99],"noted":[100],"monthly.":[101],"RESULTS:":[102],"Statistically":[103],"significant":[104],"improvements":[105],"found":[107],"all":[109],"outcomes":[111],"over":[112],"months.":[114],"correlated":[120,130,182],"DHEA.":[125],"negatively":[131],"SLAM":[133,145],"score.":[134],"A":[135],"second":[136],"order":[137],"regression":[138],"analysis":[139],"level":[143,152],"versus":[144],"score":[146],"suggested":[147,189],"that":[148],"optimal":[150],"1000":[156,195],"microg/dl.":[157,196],"most":[159],"common":[160],"effect":[162],"acne.":[164],"CONCLUSION:":[165],"response":[168],"not":[172],"clearly":[173],"dependent.":[175],"only":[183],"weakly":[184],"outcomes,":[187],"but":[188],"an":[190],"optimum":[191],"Monitoring":[197],"these":[198],"appears":[201],"have":[203],"limited":[204],"utility.":[206]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}