{"id":"https://openalex.org/W79278937","doi":"https://doi.org/10.1152/ajpendo.1991.261.2.e233","title":"Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals","display_name":"Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W79278937","doi":"https://doi.org/10.1152/ajpendo.1991.261.2.e233","mag":"79278937","pmid":"https://pubmed.ncbi.nlm.nih.gov/1872385"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.1991.261.2.e233","doi":"https://doi.org/10.1152/ajpendo.1991.261.2.e233","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1991.261.2.e233","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108227873","display_name":"\u00c9ric T. Poehlman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. T. Poehlman","raw_affiliation_strings":["Department of Medicine, College of Medicine, University of Vermont, Burlington 05405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, College of Medicine, University of Vermont, Burlington 05405","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068791834","display_name":"E. Danforth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Danforth","raw_affiliation_strings":["Department of Medicine, College of Medicine, University of Vermont, Burlington 05405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, College of Medicine, University of Vermont, Burlington 05405","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":null,"apc_paid":null,"fwci":3.5667,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.93772287,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"261","issue":"2","first_page":"E233","last_page":"E239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endurance-training","display_name":"endurance training","score":0.996999979019165},{"id":"https://openalex.org/keywords/resting-metabolic-rate","display_name":"resting metabolic rate","score":0.8460000157356262},{"id":"https://openalex.org/keywords/norepinephrine-kinetics","display_name":"norepinephrine kinetics","score":0.9670000076293945},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cycle-exercise","display_name":"cycling exercise","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vo2max","display_name":"VO2max","score":0.8090000152587891},{"id":"https://openalex.org/keywords/energy-intake","display_name":"energy intake","score":0.9599999785423279},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9610000252723694},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6000000238418579},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.878000020980835},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.7595226764678955},{"id":"https://openalex.org/C82736064","wikidata":"https://www.wikidata.org/wiki/Q623293","display_name":"Basal metabolic rate","level":2,"score":0.7590316534042358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7516805529594421},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7087022066116333},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5288439989089966},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.516463041305542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4956868886947632},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.49200960993766785},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.465961754322052},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.411188006401062},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0743127167224884}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010806","descriptor_name":"Physical Education and Training","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010807","descriptor_name":"Physical Endurance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpendo.1991.261.2.e233","doi":"https://doi.org/10.1152/ajpendo.1991.261.2.e233","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1991.261.2.e233","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:1872385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1872385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.923.5607","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.923.5607","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpendo.physiology.org/content/ajpendo/261/2/E233.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1343828113","display_name":"EFFECT OF OVER- &UNDERNUTRITION ON THYROID HORMONE","funder_award_id":"R01DK018535","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2204608017","display_name":null,"funder_award_id":"AG07857","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3934962258","display_name":"DIET, OBESITY, AND ENERGY EXPENDITURE WITH AGING","funder_award_id":"R01DK039037","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W16183774"],"related_works":["https://openalex.org/W7095369225","https://openalex.org/W2404417664","https://openalex.org/W2127454674","https://openalex.org/W1995702522","https://openalex.org/W2344647715","https://openalex.org/W2284390887","https://openalex.org/W2178342702","https://openalex.org/W1975060429","https://openalex.org/W2406524234","https://openalex.org/W2325288766"],"abstract_inverted_index":{"We":[0,191],"examined":[1],"the":[2,172,175,204],"effects":[3],"of":[4,51,66,129,142,171,174,208],"an":[5,221],"8-wk":[6],"endurance":[7,194],"training":[8,71,195],"program":[9],"(cycling":[10],"exercise)":[11],"on":[12],"resting":[13],"metabolic":[14],"rate":[15,80,141,225],"(RMR)":[16],"and":[17,30,48,54,81,95,114,151,211,226],"norepinephrine":[18],"(NE)":[19],"kinetics":[20],"in":[21,77,84,108,126,134,154,177,180,188,200,230],"19":[22],"older":[23,201,232],"persons":[24],"(64":[25],"+/-":[26],"1.6":[27],"yr).":[28],"Before":[29],"after":[31,62,70,119],"training,":[32,120],"RMR,":[33],"NE":[34,67,78,85,143,189,223],"kinetics,":[35],"maximal":[36],"O2":[37],"consumption":[38],"(VO2max),":[39],"body":[40,109],"composition,":[41],"supine":[42],"blood":[43,112,181],"pressure,":[44],"estimated":[45],"energy":[46,96,155,198,206],"intake,":[47],"fasting":[49,127],"levels":[50,128],"glucose,":[52],"insulin,":[53],"thyroid":[55],"hormones":[56],"were":[57,117,183],"measured.":[58],"RMR":[59,135],"increased":[60,68,88,222,227],"10%":[61],"training.":[63],"Resting":[64],"concentrations":[65],"24%":[69],"due":[72],"to":[73],"a":[74,139],"21%":[75],"increase":[76,133,153,216],"appearance":[79,144,224],"no":[82,104,122],"change":[83,105,123,176],"clearance.":[86],"Training":[87],"VO2max":[89],"(14%;":[90],"P":[91,99,148,160],"less":[92,100],"than":[93,101],"0.01)":[94],"intake":[97,156,229],"(12%;":[98],"0.01),":[102],"whereas":[103,121],"was":[106,124,136],"noted":[107,125],"composition.":[110],"Supine":[111],"pressure":[113,182],"plasma":[115,130],"glucose":[116],"lower":[118],"insulin.":[131],"The":[132],"associated":[137,185],"with":[138,152,186],"higher":[140],"(r":[145,157],"=":[146,149,158,161],"0.57;":[147],"0.05)":[150],"0.56;":[159],"0.05).":[162],"Together":[163],"these":[164],"two":[165],"factors":[166],"accounted":[167],"for":[168],"49%":[169],"(r2)":[170],"variation":[173],"RMR.":[178,214],"Changes":[179],"not":[184],"changes":[187],"kinetics.":[190],"conclude":[192],"that":[193],"increases":[196],"total":[197],"expenditure":[199],"individuals":[202],"by":[203,212,220],"direct":[205],"cost":[207],"physical":[209],"activity":[210],"elevating":[213],"This":[215],"is":[217],"partially":[218],"mediated":[219],"food":[228],"healthy":[231],"individuals.":[233]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}