{"id":"https://openalex.org/W79251665","doi":null,"title":"Alteration of thyroid hormone economy during alcohol withdrawal in alcoholics.","display_name":"Alteration of thyroid hormone economy during alcohol withdrawal in alcoholics.","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W79251665","mag":"79251665","pmid":"https://pubmed.ncbi.nlm.nih.gov/6926819"},"language":"en","primary_location":{"id":"pmid:6926819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6926819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug-nutrient interactions","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109282871","display_name":"Arne Melander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Melander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063578892","display_name":"Jan I. Thorell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Thorell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091468750","display_name":"Jan Wadstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wadstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00675248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"2","first_page":"113","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.0917000025510788,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcohol-withdrawal-syndrome","display_name":"alcohol withdrawal","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chronic-alcoholism","display_name":"chronic alcoholism","score":0.8669999837875366},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/reverse-t3","display_name":"reverse T3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alcohol-abstinence","display_name":"alcohol abstinence","score":0.8690000176429749},{"id":"https://openalex.org/keywords/delirium-tremens","display_name":"delirium tremens","score":0.9959999918937683},{"id":"https://openalex.org/keywords/serum-ethanol","display_name":"serum ethanol","score":0.6600000262260437},{"id":"https://openalex.org/keywords/thyroid-hormone-deiodination","display_name":"thyroid hormone deiodination","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.8280977010726929},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.793689489364624},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7265298366546631},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7166272401809692},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6669451594352722},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6653487682342529},{"id":"https://openalex.org/C2780486670","wikidata":"https://www.wikidata.org/wiki/Q7318276","display_name":"Reverse triiodothyronine","level":4,"score":0.6384280920028687},{"id":"https://openalex.org/C2776901510","wikidata":"https://www.wikidata.org/wiki/Q209647","display_name":"Delirium tremens","level":2,"score":0.6054261326789856},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5774832367897034},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5656589269638062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5250775218009949},{"id":"https://openalex.org/C2776610969","wikidata":"https://www.wikidata.org/wiki/Q205972","display_name":"Alcohol intoxication","level":4,"score":0.4515886604785919},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21808597445487976},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.18862766027450562},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16310176253318787},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16292843222618103},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.08268073201179504},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.0687192976474762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.060207366943359375}],"mesh":[{"descriptor_ui":"D000430","descriptor_name":"Alcohol Withdrawal Delirium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014285","descriptor_name":"Triiodothyronine, Reverse","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6926819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6926819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug-nutrient interactions","raw_type":"Journal Article"},{"id":"mag:79251665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6926819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1863926818","https://openalex.org/W2050269957","https://openalex.org/W2006919653","https://openalex.org/W2419637592","https://openalex.org/W4300706049","https://openalex.org/W124042435","https://openalex.org/W1268886971","https://openalex.org/W1974318452","https://openalex.org/W2026080063","https://openalex.org/W2404222064"],"abstract_inverted_index":{"Alcohol":[0],"and":[1,49,87,119,127,152,174],"alcohol":[2,20,59,134,172],"withdrawal":[3,21],"may":[4],"affect":[5],"nutritional":[6,182],"status":[7],"in":[8,32,52,113,123],"many":[9],"different":[10,56],"ways,":[11],"including":[12],"effects":[13],"on":[14,22,83,95],"thyroid":[15,23,139,145],"activity.":[16],"The":[17],"influence":[18],"of":[19,30,36,58,66,89,117,125],"hormone":[24,140,146],"economy":[25],"was":[26,73,109],"investigated":[27],"by":[28,143,149,171],"measurements":[29],"changes":[31],"the":[33,63,78,84,96,114,167],"serum":[34,64,80,115],"concentrations":[35,65],"thyroxine":[37],"(T4),":[38],"3,":[39,43],"5,":[40,44],"3'-triiodothyronine":[41],"(T3),":[42],"5'-triiodothyronine":[45],"(reverse":[46],"T3,":[47,91],"rT3),":[48],"thyrotropin":[50],"(TSH)":[51],"chronic":[53],"alcoholics":[54],"experiencing":[55],"degrees":[57],"abstinence.":[60],"In":[61],"addition,":[62],"ethanol":[67,81,101],"were":[68],"measured":[69],"at":[70],"entrance.":[71],"There":[72],"no":[74],"significant":[75,111],"correlation":[76],"between":[77],"entrance":[79],"levels,":[82],"one":[85],"hand,":[86],"those":[88,124],"T4,":[90],"rT3,":[92,120],"or":[93,104,148,176,183],"TSH,":[94],"other.":[97],"However,":[98],"during":[99],"severe":[100],"abstinence":[102,135],"(with":[103],"without":[105],"delirium":[106],"tremens),":[107],"there":[108],"a":[110,163],"increase":[112],"levels":[116],"T4":[118,151],"but":[121],"not":[122],"T3":[126],"TSH.":[128],"These":[129],"findings":[130],"indicate":[131],"that":[132,180],"(severe)":[133],"can":[136],"interfere":[137],"with":[138],"economy,":[141],"either":[142],"enhancing":[144],"secretion":[147],"reducing":[150],"rT3":[153],"deiodination.":[154],"It":[155],"is":[156],"an":[157,177],"open":[158],"question":[159],"whether":[160],"this":[161],"represents":[162],"beneficial":[164],"adaptation":[165],"to":[166],"metabolic":[168],"disturbance":[169],"caused":[170],"intoxication":[173],"abstinence,":[175],"additional":[178],"derangement":[179],"warrants":[181],"other":[184],"therapeutic":[185],"measures.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}