{"id":"https://openalex.org/W79239384","doi":null,"title":"Effect of metabolic inhibitors, methylxanthines, antioxidants, alkali metals, and corn oil on 1,2-dimethylhydrazine carcinogenicity in rats.","display_name":"Effect of metabolic inhibitors, methylxanthines, antioxidants, alkali metals, and corn oil on 1,2-dimethylhydrazine carcinogenicity in rats.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W79239384","mag":"79239384","pmid":"https://pubmed.ncbi.nlm.nih.gov/1622151"},"language":"en","primary_location":{"id":"pmid:1622151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1622151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107835300","display_name":"Roumen M. Balansky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Balansky","raw_affiliation_strings":["National Center of Oncology, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Oncology, Sofia, Bulgaria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006256593","display_name":"P. Blagoeva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Blagoeva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109080867","display_name":"Z. Mircheva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Mircheva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110121347","display_name":"Kazymir M. Pozharisski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Pozharisski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086487964","display_name":"Silvio De Flora","orcid":"https://orcid.org/0000-0002-8023-5541","observed_orcids":["https://orcid.org/0000-0002-8023-5541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S de Flora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2097,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.42544545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"12","issue":"3","first_page":"933","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-2-dimethylhydrazine","display_name":"1,2-dimethylhydrazine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.7720000147819519},{"id":"https://openalex.org/keywords/carbon-disulfide","display_name":"carbon disulfide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9810000061988831},{"id":"https://openalex.org/keywords/butylated-hydroxytoluene","display_name":"butylated hydroxytoluene","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sodium-selenite","display_name":"sodium selenite","score":0.9259999990463257},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.875},{"id":"https://openalex.org/keywords/methylxanthines","display_name":"methylxanthines","score":0.7990000247955322},{"id":"https://openalex.org/keywords/alkali-metal-salts","display_name":"alkali metal salts","score":0.824999988079071},{"id":"https://openalex.org/keywords/corn-oil-vehicle","display_name":"corn oil vehicle","score":0.5680000185966492},{"id":"https://openalex.org/keywords/intestinal-neoplasms","display_name":"intestinal tumors","score":0.6880000233650208},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.4620000123977661},{"id":"https://openalex.org/keywords/tumor-multiplicity","display_name":"tumor multiplicity","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7780313491821289},{"id":"https://openalex.org/C2778206080","wikidata":"https://www.wikidata.org/wiki/Q856775","display_name":"Corn oil","level":2,"score":0.7714263796806335},{"id":"https://openalex.org/C2779661893","wikidata":"https://www.wikidata.org/wiki/Q221945","display_name":"Butylated hydroxytoluene","level":3,"score":0.6981202363967896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6746515035629272},{"id":"https://openalex.org/C2779932572","wikidata":"https://www.wikidata.org/wiki/Q161484","display_name":"1,2-Dimethylhydrazine","level":5,"score":0.6070663928985596},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5338827967643738},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5017690658569336},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.49389010667800903},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4858676791191101},{"id":"https://openalex.org/C2777745080","wikidata":"https://www.wikidata.org/wiki/Q5277342","display_name":"Dimethylhydrazine","level":4,"score":0.4767116904258728},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4708033800125122},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4544225037097931},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4533386528491974},{"id":"https://openalex.org/C2777395278","wikidata":"https://www.wikidata.org/wiki/Q413779","display_name":"Nitrosamine","level":3,"score":0.4182090759277344},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.34867870807647705},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3105581998825073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29741814732551575},{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.2867678999900818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20293965935707092},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.15726900100708008},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.14032047986984253},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09203144907951355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002084","descriptor_name":"Butylated Hydroxytoluene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002246","descriptor_name":"Carbon Disulfide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003314","descriptor_name":"Corn Oil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004127","descriptor_name":"Dimethylhydrazines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004221","descriptor_name":"Disulfiram","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019813","descriptor_name":"1,2-Dimethylhydrazine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:1622151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1622151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unige.it:11567/303102","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/303102","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:79239384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1622151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2128607800","https://openalex.org/W2026797578","https://openalex.org/W2052198683","https://openalex.org/W2149962457","https://openalex.org/W2404238274","https://openalex.org/W1975793966","https://openalex.org/W2410499644","https://openalex.org/W2488531862","https://openalex.org/W2107828475","https://openalex.org/W2015793132"],"abstract_inverted_index":{"The":[0,277,360],"effect":[1,99],"of":[2,6,44,50,63,75,107,110,121,129,136,142,176,187,196,247,260,268,302,327,340,348,372],"the":[3,93,97,103,122,127,132,154,164,174,194,207,245,258,291,330,334,337],"oral":[4],"administration":[5],"10":[7],"compounds":[8,342],"on":[9,244,333,350],"1,2-dimethylhydrazine":[10],"(DMH)":[11],"carcinogenesis":[12],"was":[13,100,148,316],"investigated":[14],"in":[15,48,55,61,85,131,145,179,215,321,369],"180":[16],"male":[17,22],"Wistar":[18,64,86],"rats":[19,147],"and":[20,81,105,206,282,294],"510":[21],"BD6":[23,146],"rats.":[24,65,87],"DMH,":[25],"administered":[26,212,234],"s.c.":[27],"once":[28],"per":[29,219],"week":[30],"for":[31],"20":[32],"consecutive":[33],"weeks":[34],"(20":[35],"mg/kg":[36],"body":[37,322],"wt/dose),":[38],"produced":[39,150,273],"intestinal":[40,80,143,197,225,248],"(mainly":[41],"colon)":[42],"tumors":[43,84,111,144],"various":[45],"histological":[46],"type":[47],"100%":[49],"both":[51,108],"rat":[52,180],"strains":[53],"and,":[54],"addition,":[56],"caused":[57],"Zymbal":[58,82,227],"gland":[59,83,228],"carcinomas":[60],"79.7%":[62],"Pretreatment":[66],"with":[67,235,271,307,313],"disulfiram":[68],"(DSF,":[69],"500":[70],"mg/kg),":[71],"a":[72,118,202,274,345,367],"known":[73],"inhibitor":[74],"DMH":[76,95,137,177,308,351],"metabolism,":[77],"totally":[78],"prevented":[79],"When":[88],"DSF":[89,130,155],"treatment":[90,306],"started":[91],"after":[92],"first":[94],"injection,":[96],"protective":[98],"not":[101,151,183,200,222],"total,":[102],"incidence":[104],"multiplicity":[106,195,246],"types":[109],"being":[112],"comparable":[113],"to":[114,201,344,357],"those":[115],"observed":[116],"following":[117],"single":[119],"injection":[120],"carcinogen":[123],"alone.":[124],"This":[125],"confirms":[126],"involvement":[128],"initiation":[133],"stage":[134],"only":[135,152],"carcinogenesis.":[138],"A":[139],"complete":[140,355],"prevention":[141],"also":[149,162],"by":[153,163,213,318],"metabolite":[156],"carbon":[157,167],"disulfide":[158],"(250":[159],"mg/kg)":[160],"but":[161,199],"hepatotoxic":[165],"agent":[166],"tetrachloride":[168],"(1.5":[169],"ml/kg),":[170],"which":[171,218],"suggests":[172],"that":[173],"block":[175],"metabolism":[178],"liver":[181],"is":[182],"an":[184],"exclusive":[185],"property":[186],"thiono-sulfur":[188],"compounds.":[189],"Butylated":[190],"hydroxytoluene":[191],"(BHT)":[192],"decreased":[193,257],"tumors,":[198,261],"significant":[203,303,319,358],"extent.":[204],"BHT":[205],"aforementioned":[208],"metabolic":[209],"inhibitors":[210],"were":[211,233,300],"gavage":[214],"corn":[216],"oil,":[217],"se":[220],"did":[221],"significantly":[223,256],"decrease":[224],"or":[226,325],"tumors.":[229,249],"All":[230],"remaining":[231],"modulators":[232,315],"drinking":[236],"water.":[237],"Two":[238],"additional":[239],"antioxidants":[240],"triggered":[241],"opposite":[242],"effects":[243,349],"In":[250],"fact,":[251],"sodium":[252],"selenite":[253],"(10":[254,265],"mg/l)":[255,299],"number":[259],"whereas":[262],"ascorbic":[263],"acid":[264],"g/l),":[266],"irrespective":[267],"its":[269,311],"combination":[270],"CaCl2,":[272],"marked":[275],"enhancement.":[276,359],"alkali":[278],"metal":[279],"salts":[280],"CaCl2":[281],"KCl":[283],"(both":[284,296],"at":[285,297,366],"5":[286],"g/l)":[287],"as":[288,290],"well":[289],"methylxanthines":[292],"caffeine":[293],"theophylline":[295],"600":[298],"devoid":[301],"effects.":[304],"Neither":[305],"alone":[309],"nor":[310],"association":[312],"test":[314,341],"accompanied":[317],"changes":[320],"weight":[323],"gain":[324],"survival":[326],"animals.":[328],"On":[329],"whole,":[331],"depending":[332],"mechanisms":[335],"involved,":[336],"comparative":[338],"study":[339],"led":[343],"broad":[346],"array":[347],"carcinogenesis,":[352],"ranging":[353],"from":[354],"inhibition":[356],"resulting":[361],"picture":[362],"can":[363],"be":[364],"visualized":[365],"glance":[368],"Figure":[370],"1":[371],"this":[373],"article.":[374]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}