{"id":"https://openalex.org/W79165391","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1052.4","title":"Cardiorenal Sympathetic Denervation and Baroreflex Failure in Parkinson Disease with Orthostatic Hypotension","display_name":"Cardiorenal Sympathetic Denervation and Baroreflex Failure in Parkinson Disease with Orthostatic Hypotension","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W79165391","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1052.4","mag":"79165391"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.1052.4","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1052.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.1052.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050003203","display_name":"David S. Goldstein","orcid":"https://orcid.org/0000-0002-5709-9940","observed_orcids":["https://orcid.org/0000-0002-5709-9940"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S Goldstein","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108407489","display_name":"LaToya Sewell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LaToya Sewell","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057348787","display_name":"Courtney S. Holmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney S Holmes","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00950635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/orthostatic-hypotension","display_name":"orthostatic hypotension","score":1.0},{"id":"https://openalex.org/keywords/sympathetic-denervation","display_name":"sympathetic denervation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/baroreflex-failure","display_name":"baroreflex failure","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cardiac-sympathetic-denervation","display_name":"cardiac sympathetic denervation","score":0.593999981880188},{"id":"https://openalex.org/keywords/renal-denervation","display_name":"renal denervation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/noradrenergic-denervation","display_name":"noradrenergic denervation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/plasma-norepinephrine","display_name":"plasma norepinephrine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/valsalva-maneuver","display_name":"Valsalva maneuver","score":0.7919999957084656},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.8995752334594727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7626955509185791},{"id":"https://openalex.org/C73787029","wikidata":"https://www.wikidata.org/wiki/Q7104929","display_name":"Orthostatic vital signs","level":3,"score":0.753515362739563},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.6931748390197754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.579146146774292},{"id":"https://openalex.org/C2781177144","wikidata":"https://www.wikidata.org/wiki/Q896883","display_name":"Pure autonomic failure","level":4,"score":0.5244353413581848},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5020334720611572},{"id":"https://openalex.org/C2777517520","wikidata":"https://www.wikidata.org/wiki/Q1427231","display_name":"Valsalva maneuver","level":3,"score":0.4260701835155487},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.41031110286712646},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.376615971326828},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.26982229948043823}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.1052.4","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.1052.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.1052.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000120626","https://openalex.org/W2169379169","https://openalex.org/W2094591619","https://openalex.org/W133110432","https://openalex.org/W2048332572","https://openalex.org/W2093664273","https://openalex.org/W2287086221","https://openalex.org/W2046969478","https://openalex.org/W1969617719","https://openalex.org/W2012934109"],"abstract_inverted_index":{"Background":[0],"About":[1],"40%":[2],"of":[3,38,55,158],"Parkinson":[4],"disease":[5],"(PD)":[6],"patients":[7,27],"have":[8],"orthostatic":[9,76,102],"hypotension":[10],"(OH).":[11],"We":[12],"tested":[13],"whether":[14],"cardiac":[15,147],"and":[16,20,42,71,90,100,110,125,134,146,150],"renal":[17,43,91,135,145],"sympathetic":[18],"denervation":[19,149],"baroreflex":[21,151],"failure":[22,152],"characterize":[23],"PD+OH.":[24],"Methods":[25],"PD":[26],"were":[28,51,117,138],"stratified":[29],"into":[30],"two":[31],"groups":[32],"based":[33],"on":[34],"presence":[35],"or":[36],"absence":[37],"OH.":[39,156],"Interventricular":[40],"septum":[41],"cortex":[44],"6\u2010[18F]fluorodopamine\u2010derived":[45],"radioactivity":[46],"by":[47,62,74],"positron":[48],"emission":[49],"tomography":[50],"expressed":[52],"as":[53],"ratios":[54,93,122,130,137],"liver":[56],"radioactivity.":[57],"Baroreflex\u2010cardiovagal":[58,108],"function":[59,73],"was":[60],"assessed":[61],"interbeat":[63],"interval\u2010systolic":[64],"pressure":[65],"relationships":[66],"during":[67],"the":[68,111],"Valsalva":[69],"maneuver":[70],"baroreflex\u2010sympathoneural":[72],"fractional":[75,112],"increments":[77,103],"in":[78,104,114],"plasma":[79,105,115],"norepinephrine":[80],"(NE).":[81],"Results":[82],"The":[83],"PD+OH":[84],"group":[85],"had":[86],"low":[87,96],"mean":[88],"septum:liver":[89,121],"cortex:liver":[92,129,136],"(p<0.0001,":[94],"p=0.02),":[95],"baroreflex\u2010cardiovagal":[97],"gain":[98,109],"(p<0.0001),":[99],"small":[101],"NE":[106,116],"(p<0.0001).":[107],"increment":[113],"closely":[118],"related":[119,127],"to":[120,128],"(p<0.0001;":[123],"p=0.009)":[124],"weakly":[126],"(p=0.05;":[131],"p=0.09).":[132],"Septum:liver":[133],"positively":[139],"correlated":[140],"(p=0.0001).":[141],"Conclusions":[142],"In":[143],"PD,":[144],"noradrenergic":[148],"are":[153],"associated":[154],"with":[155],"Source":[157],"research":[159],"support:":[160],"Intramural":[161],"Research":[162],"Program,":[163],"NINDS,":[164],"NIH":[165]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
