{"id":"https://openalex.org/W79130609","doi":null,"title":"Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes.","display_name":"Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes.","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W79130609","mag":"79130609","pmid":"https://pubmed.ncbi.nlm.nih.gov/9660486"},"language":"en","primary_location":{"id":"pmid:9660486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9660486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059784129","display_name":"Ram Kannan","orcid":"https://orcid.org/0000-0002-1583-3414","observed_orcids":["https://orcid.org/0000-0002-1583-3414"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Kannan","raw_affiliation_strings":["Division of Gastrointestinal and Liver Diseases, University of Southern California School of Medicine, Los Angeles 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal and Liver Diseases, University of Southern California School of Medicine, Los Angeles 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Bao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Bao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079728776","display_name":"Aravind V. Mittur","orcid":"https://orcid.org/0000-0002-6488-4154","observed_orcids":["https://orcid.org/0000-0002-6488-4154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Mittur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022976296","display_name":"Usha P. Andley","orcid":"https://orcid.org/0000-0001-7049-7591","observed_orcids":["https://orcid.org/0000-0001-7049-7591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U P Andley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043356624","display_name":"Neil Kaplowitz","orcid":"https://orcid.org/0000-0002-9424-393X","observed_orcids":["https://orcid.org/0000-0002-9424-393X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Kaplowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.557,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53058252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"8","first_page":"1379","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.08070000261068344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-transport","display_name":"glutathione transport","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hle-b3-cells","display_name":"HLE-B3 cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sodium-dependence","display_name":"sodium dependence","score":0.6370000243186951},{"id":"https://openalex.org/keywords/plasma-membrane-vesicles","display_name":"plasma membrane vesicles","score":0.7919999957084656},{"id":"https://openalex.org/keywords/xenopus-oocytes","display_name":"Xenopus oocytes","score":0.6460000276565552},{"id":"https://openalex.org/keywords/acivicin","display_name":"acivicin","score":0.5989999771118164},{"id":"https://openalex.org/keywords/buthionine-sulfoximine","display_name":"buthionine sulfoximine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/carrier-mediated-transport","display_name":"carrier-mediated transport","score":0.6460000276565552},{"id":"https://openalex.org/keywords/lens-epithelium","display_name":"lens epithelium","score":0.4230000078678131},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.8985868692398071},{"id":"https://openalex.org/C2777476445","wikidata":"https://www.wikidata.org/wiki/Q5002519","display_name":"Buthionine sulfoximine","level":4,"score":0.7118391394615173},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.6564367413520813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5191061496734619},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48692023754119873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4478503167629242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30382901430130005},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08783850073814392},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019328","descriptor_name":"Buthionine Sulfoximine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9660486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9660486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:79130609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9660486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3153079640","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY002687","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7254919439","display_name":"ALPHA-CRYSTALLIN FUNCTION IN LENS BIOLOGY","funder_award_id":"R01EY005681","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7780301029","display_name":"LENS GLUTATHIONE TRANSPORTERS","funder_award_id":"5r01ey011135-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W8128757","https://openalex.org/W12344242","https://openalex.org/W49713821","https://openalex.org/W153838543","https://openalex.org/W164346062","https://openalex.org/W1223981148","https://openalex.org/W1530747259","https://openalex.org/W1596027979","https://openalex.org/W1733159128","https://openalex.org/W1847091853","https://openalex.org/W1966585015","https://openalex.org/W1985032385","https://openalex.org/W2007064404","https://openalex.org/W2016898117","https://openalex.org/W2017525363","https://openalex.org/W2025082768","https://openalex.org/W2056963401","https://openalex.org/W2072585523","https://openalex.org/W2134106576","https://openalex.org/W2409475621"],"related_works":["https://openalex.org/W12344242","https://openalex.org/W153838543","https://openalex.org/W164346062","https://openalex.org/W2026871715","https://openalex.org/W90317411","https://openalex.org/W1530747259","https://openalex.org/W7096764253","https://openalex.org/W1505069371","https://openalex.org/W2134106576","https://openalex.org/W2401284641"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"reduced":[3],"glutathione":[4],"(GSH)":[5],"transport":[6,25,121,352],"in":[7,26,53,66,101,108,111,134,175,186,206,225,244,282,299,303,340,359],"cultured":[8,300],"human":[9],"lens":[10],"epithelial":[11],"cells":[12,40,107,301,313,344],"(HLE-B3)":[13],"and":[14,18,47,80,103,124,155,169,260,302,314,353],"plasma":[15,136,246,315],"membrane":[16,137,247,316],"vesicles":[17,138,248,317],"to":[19,117,240],"study":[20],"the":[21,112,125,187,360],"expression":[22,144],"of":[23,59,87,122,127,167,189,262,297,362],"GSH":[24,54,96,123,156,170,201,223,231,243,271,319,332,334,351],"Xenopus":[27],"laevis":[28,153,329],"oocytes":[29,154,284,330],"injected":[30,150,253,327],"with":[31,42,210,254],"poly(A)+":[32,147,177,325],"RNA":[33,148,257,326],"from":[34,139,237,249],"HLE-B3":[35,39,106,140,146,176,250,255,312,324,343],"cells.":[36,141,251],"METHODS:":[37],"Confluent":[38],"pretreated":[41],"10":[43],"mM":[44,49,191,242],"DL-buthionine":[45],"sulfoximine":[46],"0.5":[48],"acivicin":[50,102],"were":[51,99,132,159,173,276],"used":[52],"uptake":[55,58,89,97,130,157,166,188,202,224,232,259,298,335],"studies.":[56],"The":[57,84,120,165,273,294],"35S-GSH":[60,168],"was":[61,90,149,184,203,228,306,336],"performed":[62,160],"for":[63,349,354],"30":[64],"minutes":[65],"either":[67],"NaCl":[68,109,226],"medium":[69,74,110,208,212,227],"(Na+-containing)":[70],"or":[71],"choline":[72],"chloride":[73],"(Na+-free)":[75],"at":[76,269],"37":[77],"degrees":[78,82],"C":[79],"4":[81],"C.":[83],"molecular":[85,295],"form":[86,296],"35S":[88],"determined":[91,133,174],"by":[92,320],"high-performance":[93],"liquid":[94],"chromatography.":[95],"kinetics":[98],"studied":[100],"buthionine":[104],"sulfoximine-treated":[105],"concentration":[113],"range":[114],"0.01":[115],"microM":[116,239],"50":[118],"mM.":[119],"effect":[126],"Na+":[128,267,338],"on":[129],"also":[131],"mixed":[135,245],"In":[142],"oocyte":[143,304],"studies,":[145],"into":[151],"X.":[152],"experiments":[158],"3":[161],"days":[162],"after":[163],"injection.":[164],"efflux":[171,261,274],"rates":[172,275],"RNA-injected":[178],"oocytes.":[179],"RESULTS:":[180],"No":[181],"significant":[182],"difference":[183],"found":[185],"1":[190],"GSH+/-acivicin":[192],"(17.7+/-4.3":[193],"versus":[194,214,286],"15.7+/-1.4":[195],"picomoles/min(-1)":[196,216],"per":[197,217,289,291],"10(6)":[198,218],"cells).":[199],"However,":[200],"significantly":[204],"lower":[205],"Na+-free":[207],"compared":[209],"Na+-containing":[211],"(10.3+/-0.7":[213],"16.8+/-0.9":[215],"cells;":[219],"P":[220],"<":[221],"0.01).":[222],"carrier":[229],"mediated.":[230],"showed":[233,265],"partial":[234,266],"sodium":[235],"dependency":[236,268],"5":[238,241],"Oocytes":[252],"poly(A)":[256],"expressed":[258,331],"GSH.":[263,310],"Uptake":[264],"various":[270],"concentrations.":[272],"approximately":[277],"30-fold":[278],"higher":[279],"than":[280],"those":[281],"water-injected":[283],"(0.48+/-0.03":[285],"0.016+/-0.005":[287],"(nanomoles":[288],"hour(-1)":[290],"oocyte,":[292],"respectively).":[293],"studies":[305],"predominantly":[307],"as":[308],"intact":[309],"CONCLUSIONS:":[311],"transported":[318],"a":[321,346],"carrier-mediated":[322],"process.":[323],"X":[328],"transport.":[333],"partially":[337],"dependent":[339],"all":[341],"systems.":[342],"offer":[345],"useful":[347],"model":[348],"characterizing":[350],"studying":[355],"its":[356],"regulatory":[357],"role":[358],"etiology":[361],"cataracts.":[363]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
