{"id":"https://openalex.org/W79116754","doi":null,"title":"Comparison between starvation and consumption of a high protein diet in rats: hepatic metabolites and amino acid levels during the first 24 hours.","display_name":"Comparison between starvation and consumption of a high protein diet in rats: hepatic metabolites and amino acid levels during the first 24 hours.","publication_year":1986,"publication_date":"1986-10-01","ids":{"openalex":"https://openalex.org/W79116754","mag":"79116754","pmid":"https://pubmed.ncbi.nlm.nih.gov/3803677"},"language":"en","primary_location":{"id":"pmid:3803677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3803677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048163166","display_name":"Brigitte Bois-Joyeux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Bois-Joyeux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079695405","display_name":"Marc Chanez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Chanez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067334032","display_name":"Belkacem Azzout","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Azzout","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067102240","display_name":"Brigitte Delhomme","orcid":"https://orcid.org/0009-0007-3110-6560","observed_orcids":["https://orcid.org/0009-0007-3110-6560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Delhomme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111452686","display_name":"J P\u00e9ret","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Peret","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.761,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68828937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"5","first_page":"239","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.25540000200271606,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.25540000200271606,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.2328999936580658,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.12960000336170197,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/starvation","display_name":"starvation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/high-protein-diet","display_name":"high-protein diet","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatic-metabolites","display_name":"hepatic metabolites","score":0.9390000104904175},{"id":"https://openalex.org/keywords/amino-acid-levels","display_name":"amino acid levels","score":0.7770000100135803},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/urea-synthesis","display_name":"urea synthesis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/amino-acid-oxidation","display_name":"amino acid oxidation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ketone-bodies","display_name":"ketone bodies","score":0.9300000071525574},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.6129999756813049},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.7319999933242798},{"id":"https://openalex.org/keywords/aspartate","display_name":"aspartic acid","score":0.8510000109672546},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cytosolic-redox-state","display_name":"cytosolic redox state","score":0.796999990940094},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.8723725080490112},{"id":"https://openalex.org/C31532488","wikidata":"https://www.wikidata.org/wiki/Q746183","display_name":"Ketone bodies","level":3,"score":0.7986842393875122},{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.7214533090591431},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.6446356773376465},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.6301669478416443},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.6045295596122742},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5797996520996094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5750989317893982},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5567488670349121},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5174894332885742},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5160848498344421},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.5152435898780823},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.493038147687912},{"id":"https://openalex.org/C138463869","wikidata":"https://www.wikidata.org/wiki/Q14901436","display_name":"Starvation response","level":3,"score":0.4837763011455536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47036096453666687},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.43622374534606934},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.41947609186172485},{"id":"https://openalex.org/C2780606744","wikidata":"https://www.wikidata.org/wiki/Q853930","display_name":"Starvation","level":2,"score":0.3693544268608093},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11096948385238647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007657","descriptor_name":"Ketone Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013217","descriptor_name":"Starvation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3803677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3803677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabete & metabolisme","raw_type":"Comparative Study"},{"id":"mag:79116754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3803677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W87613572","https://openalex.org/W1529804598","https://openalex.org/W1671344564","https://openalex.org/W2013439077","https://openalex.org/W2416255907","https://openalex.org/W2068848757","https://openalex.org/W2010417156","https://openalex.org/W2346311579","https://openalex.org/W1868366125","https://openalex.org/W1579390242"],"abstract_inverted_index":{"Changes":[0],"in":[1,27,54,146],"hepatic":[2,110],"levels":[3],"of":[4,35,40,57,151],"lactate,":[5],"pyruvate,":[6],"phosphoenolpyruvate,":[7],"alpha-ketoglutarate,":[8],"malate,":[9],"oxaloacetate,":[10],"adenine":[11],"nucleotides,":[12],"inorganic":[13],"phosphate,":[14],"ketone":[15,92],"bodies,":[16],"alanine,":[17],"serine,":[18],"glycine,":[19],"aspartate,":[20,111],"glutamate,":[21],"valine":[22],"and":[23,113,117,138,173,181],"urea":[24,114],"were":[25,48,84,115],"examined":[26],"adult":[28],"rats":[29],"during":[30,165],"the":[31,55,61,68,79,82,88,100,122,127,147,153,168],"first":[32,148],"24":[33,149],"h":[34,77,137,150],"either":[36],"starvation":[37],"or":[38,60],"consumption":[39],"a":[41,74],"high":[42],"protein":[43],"(HP)":[44],"diet.":[45,90,129],"No":[46],"differences":[47],"found":[49],"between":[50],"these":[51],"two":[52],"conditions":[53],"concentration":[56],"metabolites":[58],"studied":[59],"cytosolic":[62,69],"redox":[63],"state.":[64],"Under":[65],"both":[66,131,171],"conditions,":[67],"phosphorylation":[70],"state":[71],"decreased":[72],"to":[73],"low":[75,116,140],"15":[76],"into":[78],"experiment":[80],"but":[81],"changes":[83],"more":[85],"pronounced":[86],"on":[87],"HP":[89,128,166],"Hepatic":[91],"bodies":[93],"rose":[94],"sharply":[95],"after":[96],"12":[97],"h,":[98],"with":[99],"increase":[101],"2.5":[102],"times":[103],"greater":[104],"for":[105,126,156,170],"starved":[106],"rats.":[107],"In":[108,130],"starvation,":[109,152],"valine,":[112],"glycine":[118],"was":[119,124],"high,":[120],"whereas":[121],"opposite":[123],"seen":[125],"groups,":[132],"alanine":[133],"fell":[134],"within":[135],"9":[136],"remained":[139],"thereafter.":[141],"These":[142],"findings":[143],"suggest":[144],"that,":[145],"energy":[154,169],"necessary":[155],"gluconeogenesis":[157,172],"is":[158],"obtained":[159],"from":[160,177],"fatty":[161,178],"acid":[162,179,183],"oxidation,":[163],"while":[164],"feeding":[167],"ureagenesis":[174],"are":[175],"derived":[176],"oxidation":[180],"amino":[182],"oxidation.":[184]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}