{"id":"https://openalex.org/W78895978","doi":null,"title":"The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase: biochemistry, structure, occurrence and evolution.","display_name":"The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase: biochemistry, structure, occurrence and evolution.","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W78895978","mag":"78895978","pmid":"https://pubmed.ncbi.nlm.nih.gov/9461340"},"language":"en","primary_location":{"id":"pmid:9461340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9461340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological chemistry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A Habenicht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"A Habenicht","raw_affiliation_strings":["Institut f\u00fcr Industrielle Genetik, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Industrielle Genetik, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I100066346"],"apc_list":null,"apc_paid":null,"fwci":0.8277,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.68536726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"378","issue":"12","first_page":"1413","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0940999984741211,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nadp-dependent-dehydrogenase","display_name":"NADP-dependent dehydrogenase","score":0.7099999785423279},{"id":"https://openalex.org/keywords/3-phosphoglycerate","display_name":"3-phosphoglycerate","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nadph","display_name":"NADPH","score":0.6150000095367432},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cofactor-binding","display_name":"cofactor binding","score":0.6840000152587891},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/archaea","display_name":"archaea","score":0.6769999861717224},{"id":"https://openalex.org/keywords/bacteria","display_name":"bacteria","score":0.949999988079071},{"id":"https://openalex.org/keywords/eukarya","display_name":"Eukarya","score":0.9120000004768372},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate","display_name":"glyceraldehyde-3-phosphate","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C134792803","wikidata":"https://www.wikidata.org/wiki/Q424886","display_name":"Glyceraldehyde 3-phosphate dehydrogenase","level":4,"score":0.8418259024620056},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.8199976682662964},{"id":"https://openalex.org/C2781272698","wikidata":"https://www.wikidata.org/wiki/Q423211","display_name":"Glyceraldehyde","level":4,"score":0.8126257658004761},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7028247117996216},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.6436685919761658},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.6108189821243286},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.48836657404899597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4761476516723633},{"id":"https://openalex.org/C151325109","wikidata":"https://www.wikidata.org/wiki/Q22327132","display_name":"Branched-chain alpha-keto acid dehydrogenase complex","level":4,"score":0.43360012769699097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.370094895362854},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3002881407737732}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005987","descriptor_name":"Glyceraldehyde-3-Phosphate Dehydrogenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005987","descriptor_name":"Glyceraldehyde-3-Phosphate Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005987","descriptor_name":"Glyceraldehyde-3-Phosphate Dehydrogenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9461340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9461340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological chemistry","raw_type":"Journal Article"},{"id":"mag:78895978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9461340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2074235086","https://openalex.org/W1969723239","https://openalex.org/W2076582010","https://openalex.org/W7095689172","https://openalex.org/W2001145422","https://openalex.org/W2055934147","https://openalex.org/W2072589942","https://openalex.org/W2126616579","https://openalex.org/W1990769556","https://openalex.org/W1981445824"],"abstract_inverted_index":{"The":[0,63,99,124],"non-phosphorylating":[1,44,85,104],"glyceraldehyde-3-phosphate":[2,9,28,36,45,53,86,105],"dehydrogenase":[3,46,61,87,106],"catalyses":[4],"the":[5,13,24,32,43,51,59,76,84,103,108,117,127],"irreversible":[6],"reaction":[7,34],"of":[8,15,35,58,67,102,126],"to":[10,17,23,37,50,136],"3-phosphoglycerate":[11],"by":[12,80],"reduction":[14],"NADP":[16],"NADPH.":[18],"This":[19],"is":[20,47,130],"in":[21,75,91,132],"contrast":[22],"extensively":[25],"analysed":[26],"phosphorylating":[27,52],"dehydrogenases":[29,54,65,111,129],"which":[30],"catalyse":[31],"reversible":[33],"1,3-bisphosphoglycerate.":[38],"Sequence":[39],"analysis":[40],"revealed":[41],"that":[42],"not":[48],"related":[49],"but":[55],"a":[56,113,133,137],"member":[57],"aldehyde":[60,64,110,128],"superfamily.":[62],"are":[66],"ancient":[68],"origin":[69],"and":[70,97,107],"they":[71],"have":[72],"already":[73],"existed":[74],"progenote":[77],"as":[78,140],"indicated":[79],"phylogenetic":[81],"analysis.":[82],"Thus":[83],"can":[88],"be":[89],"found":[90],"all":[92],"three":[93],"domains,":[94],"archaea,":[95],"bacteria":[96],"eukarya.":[98],"catalytic":[100],"mechanism":[101,115],"other":[109],"resembles":[112],"thioester":[114],"involving":[116],"universally":[118],"conserved":[119],"cysteine":[120],"298":[121],"(pea":[122],"GAPN).":[123],"cofactor":[125],"bound":[131],"new":[134],"mode":[135],"structure":[138],"described":[139],"beta-alpha,beta-fold.":[141]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}