{"id":"https://openalex.org/W788076136","doi":"https://doi.org/10.1161/res.115.suppl_1.15","title":"Abstract 15: Limiting GRK2 in the Ischemic Heart can Promote Cardiac Regeneration","display_name":"Abstract 15: Limiting GRK2 in the Ischemic Heart can Promote Cardiac Regeneration","publication_year":2014,"publication_date":"2014-07-18","ids":{"openalex":"https://openalex.org/W788076136","doi":"https://doi.org/10.1161/res.115.suppl_1.15","mag":"788076136"},"language":"en","primary_location":{"id":"doi:10.1161/res.115.suppl_1.15","doi":"https://doi.org/10.1161/res.115.suppl_1.15","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.115.suppl_1.15","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112289292","display_name":"Maria Cecilia Scimia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Cecilia Scimia","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Maria Cecilia Scimia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Maria Cecilia Scimia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101930491","display_name":"Lin Zuo","orcid":"https://orcid.org/0000-0001-5399-3825","observed_orcids":["https://orcid.org/0000-0001-5399-3825"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Zuo","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Lin Zuo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lin Zuo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023826327","display_name":"Kate E Sydnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate E Sydnes","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Kate E Sydnes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Kate E Sydnes","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025734088","display_name":"Daniel A. Zuppo","orcid":"https://orcid.org/0000-0002-4229-0849","observed_orcids":["https://orcid.org/0000-0002-4229-0849"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A Zuppo","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Daniel A Zuppo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Daniel A Zuppo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044556689","display_name":"Erhe Gao","orcid":"https://orcid.org/0000-0002-5151-7857","observed_orcids":["https://orcid.org/0000-0002-5151-7857"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erhe Gao","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Erhe Gao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Erhe Gao","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075648082","display_name":"Walter J. Koch","orcid":"https://orcid.org/0000-0002-8522-530X","observed_orcids":["https://orcid.org/0000-0002-8522-530X","https://orcid.org/0000-0002-0609-8649"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter J Koch","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Walter J Koch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Walter J Koch","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"115","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grk2","display_name":"GRK2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.949999988079071},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9829999804496765},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-kinases","display_name":"G protein-coupled receptor kinases","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/c-kit-cells","display_name":"c-kit+ cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/grk2-inhibition","display_name":"GRK2 inhibition","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C78976303","wikidata":"https://www.wikidata.org/wiki/Q14907967","display_name":"Beta adrenergic receptor kinase","level":4,"score":0.8665258884429932},{"id":"https://openalex.org/C33235085","wikidata":"https://www.wikidata.org/wiki/Q4355943","display_name":"G protein-coupled receptor kinase","level":4,"score":0.6318487524986267},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5130900144577026},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.46400609612464905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.453555166721344},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.43964138627052307},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4305899441242218},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.42851153016090393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41882550716400146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38635414838790894},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3847927153110504},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.35900282859802246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3551827669143677},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3435167968273163},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.32791709899902344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3263234496116638},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0977250337600708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.115.suppl_1.15","doi":"https://doi.org/10.1161/res.115.suppl_1.15","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.115.suppl_1.15","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W236423874","https://openalex.org/W2155007822","https://openalex.org/W2137086434","https://openalex.org/W2950675033","https://openalex.org/W2166137616","https://openalex.org/W4377020437","https://openalex.org/W1780228535","https://openalex.org/W1906216417","https://openalex.org/W2156460525","https://openalex.org/W2765627982"],"abstract_inverted_index":{"The":[0],"detrimental":[1],"role":[2,44],"of":[3,30,50,90,93,132,138,159,189,215,276,295],"G":[4],"protein-coupled":[5],"receptor":[6],"(GPCR)":[7],"kinase":[8],"(GRK2)":[9],"following":[10],"cardiac":[11,108,160],"injury/stress":[12],"has":[13,24,57],"been":[14,58],"documented":[15],"over":[16],"the":[17,77,107,133,207,264,270,292],"last":[18],"two":[19],"decades.":[20],"Importantly,":[21],"our":[22,63],"lab":[23,64],"shown":[25],"that":[26,69,79,256,263],"inhibition":[27,89,219,297],"or":[28,183,218],"deletion":[29],"GRK2":[31,70,94,114,121,139,216,233,249,277,296],"in":[32,45,76,192,206,244,269],"cardiomyocytes":[33],"can":[34,71],"prevent":[35],"and":[36,65,87,125,151,156,172,174,204,235,250],"also":[37,126,200,258],"rescue":[38],"heart":[39,78,272],"failure":[40],"(HF)":[41],"phenotypes.":[42],"Its":[43],"GPCR":[46],"desensitization":[47],"including":[48,162],"regulation":[49],"\u03b2-adrenergic":[51],"receptors":[52],"(\u03b2ARs)":[53],"during":[54],"HF":[55,146],"development":[56],"well":[59,195],"characterized.":[60],"However,":[61],"recently":[62],"others":[66],"have":[67,72],"found":[68,238],"novel":[73,289],"GPCR-independent":[74],"effects":[75,86,99],"appear":[80],"to":[81,83,97,186,210,228,279],"contribute":[82,96],"its":[84,221],"pathological":[85],"thus,":[88],"these":[91],"actions":[92],"may":[95],"therapeutic":[98,293],"seen.":[100],"In":[101,119],"this":[102,251],"study":[103],"we":[104,144],"explored":[105],"whether":[106],"repair":[109,161],"observed":[110],"with":[111,129,180,231,247,253,273],"lower":[112,248],"myocardial":[113,153,265],"might":[115],"involve":[116],"regenerative":[117,285],"processes.":[118],"cardiac-specific":[120],"knockout":[122],"(KO)":[123],"mice":[124,128,167,171,230],"transgenic":[127],"cardiac-targeted":[130],"expression":[131,217],"\u03b2ARKct,":[134],"a":[135,282],"peptide":[136],"inhibitor":[137],"activation":[140],"via":[141,147,220],"G\u03b2\u03b3":[142],"sequestration,":[143],"induced":[145],"coronary":[148],"artery":[149],"ligation":[150],"subsequent":[152],"infarction":[154],"(MI)":[155],"measured":[157],"aspects":[158],"potential":[163,224,294],"regeneration":[164,225],"indices.":[165],"Post-MI":[166],"(GRK2":[168],"KO,":[169],"\u03b2ARKct":[170],"wild-type":[173],"non-transgenic":[175],"control":[176,229],"mice)":[177],"were":[178,257],"treated":[179],"5-ethynyl-2\u2019-deoxyuridine":[181],"(EdU)":[182],"Bromodeoxyuridine":[184],"(BrDU)":[185],"examine":[187],"indices":[188],"DNA":[190],"proliferation":[191],"myocytes":[193,205,243,255],"as":[194,196],"Ki67":[197],"staining.":[198],"We":[199,237],"quantitated":[201],"c-kit+":[202],"cells":[203],"post-MI":[208,245,271],"hearts":[209,246],"compare":[211],"how":[212],"either":[213],"loss":[214],"C-terminus":[222],"altered":[223],"mechanisms":[226],"compared":[227],"endogenous":[232],"levels":[234],"activity.":[236],"significantly":[239],"more":[240],"BrDU":[241],"positive":[242],"correlated":[252],"increased":[254],"cKit+.":[259],"Thus,":[260],"it":[261],"appears":[262],"functional":[266],"improvement":[267],"seen":[268],"targeted":[274],"lowering":[275],"involves,":[278],"at":[280],"least":[281],"certain":[283],"extent,":[284],"mechanisms.":[286],"This":[287],"adds":[288],"insight":[290],"into":[291],"for":[298],"HF.":[299]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
