{"id":"https://openalex.org/W787562425","doi":null,"title":"A 450K arsenite-binding protein of the rabbit liver cytosol.","display_name":"A 450K arsenite-binding protein of the rabbit liver cytosol.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W787562425","mag":"787562425"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/186945","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/186945","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113457752","display_name":"Gregory M. Bogdan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gregory M. Bogdan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113457752"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.3212999999523163,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cytosol","display_name":"liver cytosol","score":0.8209999799728394},{"id":"https://openalex.org/keywords/inorganic-arsenic","display_name":"inorganic arsenic","score":0.7509999871253967},{"id":"https://openalex.org/keywords/arsenite","display_name":"arsenite","score":0.6140000224113464},{"id":"https://openalex.org/keywords/arsenic-toxicity","display_name":"arsenic toxicity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/protein-sulfhydryl-groups","display_name":"protein sulfhydryl groups","score":0.796999990940094},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alpha-ketoglutarate-dehydrogenase","display_name":"alpha-ketoglutarate dehydrogenase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6859999895095825},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.597000002861023},{"id":"https://openalex.org/keywords/cyanogen-bromide-cleavage","display_name":"cyanogen bromide cleavage","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2776305511","wikidata":"https://www.wikidata.org/wiki/Q10859825","display_name":"Arsenite","level":3,"score":0.6075785756111145},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.588379442691803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5373809337615967},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.43026983737945557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42474865913391113},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.42334628105163574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3333733081817627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29353439807891846},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15581014752388},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1206827163696289},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.0865824818611145},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/186945","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/186945","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation-Reproduction (electronic)"},{"id":"mag:787562425","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/186945","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W3077276","https://openalex.org/W34780839","https://openalex.org/W44456527","https://openalex.org/W103870986","https://openalex.org/W190120074","https://openalex.org/W191109327","https://openalex.org/W334182481","https://openalex.org/W392713253","https://openalex.org/W1479912346","https://openalex.org/W1642823164","https://openalex.org/W1805247766","https://openalex.org/W1853068488","https://openalex.org/W1918363838","https://openalex.org/W1963951722","https://openalex.org/W1964405342","https://openalex.org/W1965937109","https://openalex.org/W1967850583","https://openalex.org/W1968621561","https://openalex.org/W1969439381","https://openalex.org/W1971586939","https://openalex.org/W1972305678","https://openalex.org/W1972677993","https://openalex.org/W1974361577","https://openalex.org/W1976068701","https://openalex.org/W1979297485","https://openalex.org/W1979422693","https://openalex.org/W1981671259","https://openalex.org/W1985818628","https://openalex.org/W1989497541","https://openalex.org/W1990045949","https://openalex.org/W1990887465","https://openalex.org/W1991857985","https://openalex.org/W1995106657","https://openalex.org/W1995197759","https://openalex.org/W1995335028","https://openalex.org/W1996216718","https://openalex.org/W2000662223","https://openalex.org/W2001043181","https://openalex.org/W2002127429","https://openalex.org/W2007964338","https://openalex.org/W2008715208","https://openalex.org/W2010486579","https://openalex.org/W2010663826","https://openalex.org/W2011501030","https://openalex.org/W2014023229","https://openalex.org/W2014901209","https://openalex.org/W2015267490","https://openalex.org/W2016074408","https://openalex.org/W2020026267","https://openalex.org/W2023356380","https://openalex.org/W2023402382","https://openalex.org/W2026632888","https://openalex.org/W2027745718","https://openalex.org/W2028394587","https://openalex.org/W2030253519","https://openalex.org/W2031369892","https://openalex.org/W2031978464","https://openalex.org/W2032458072","https://openalex.org/W2033247477","https://openalex.org/W2034380688","https://openalex.org/W2035691613","https://openalex.org/W2040100629","https://openalex.org/W2045350084","https://openalex.org/W2045563402","https://openalex.org/W2045740906","https://openalex.org/W2046269325","https://openalex.org/W2048841499","https://openalex.org/W2053574449","https://openalex.org/W2054491767","https://openalex.org/W2055562179","https://openalex.org/W2058424779","https://openalex.org/W2058986899","https://openalex.org/W2059707861","https://openalex.org/W2062458061","https://openalex.org/W2064173649","https://openalex.org/W2073861393","https://openalex.org/W2076549841","https://openalex.org/W2079146947","https://openalex.org/W2079639390","https://openalex.org/W2081940306","https://openalex.org/W2084580072","https://openalex.org/W2087706805","https://openalex.org/W2089496907","https://openalex.org/W2092783724","https://openalex.org/W2095358360","https://openalex.org/W2101420559","https://openalex.org/W2111301002","https://openalex.org/W2128635872","https://openalex.org/W2132068224","https://openalex.org/W2173424827","https://openalex.org/W2226600433","https://openalex.org/W2286150756","https://openalex.org/W2300313105","https://openalex.org/W2325541920","https://openalex.org/W2329665214","https://openalex.org/W2330121082","https://openalex.org/W2332148883","https://openalex.org/W2397581674","https://openalex.org/W2404632468","https://openalex.org/W2489378082","https://openalex.org/W3214273100"],"related_works":["https://openalex.org/W2033424457","https://openalex.org/W1979607902","https://openalex.org/W1990896309","https://openalex.org/W2043920764","https://openalex.org/W3181472166","https://openalex.org/W2006115545","https://openalex.org/W2000755933","https://openalex.org/W2610939215","https://openalex.org/W2017181136","https://openalex.org/W2010419238"],"abstract_inverted_index":{"Inorganic":[0],"arsenic":[1,21,37,53,142],"administered":[2,117],"to":[3,40,61,76,125,170,191,213],"animals":[4],"is":[5,326],"primarily":[6],"associated":[7],"with":[8,93,205,245,279],"liver":[9,41,111],"cytosolic":[10,42,70,86],"macromolecules.":[11],"The":[12,121],"specifics":[13],"of":[14,35,51,85,96,123,222,226,256,314,320],"this":[15,73,300],"binding":[16,54,122,148,190,212],"and":[17,48,72,99,132,139,160,185,198,209,231,317,323],"its":[18,77,137],"role":[19],"in":[20,57,110,119,289],"toxicity":[22],"have":[23],"never":[24],"been":[25],"fully":[26],"examined.":[27],"This":[28],"dissertation":[29],"concentrated":[30],"on":[31,136,217,283],"determining":[32],"the":[33,44,49,66,126,218,223,236,253,257,269,291],"species":[34,67],"inorganic":[36],"which":[38,68,176,247,277],"binds":[39],"proteins,":[43],"specific":[45],"proteins":[46,71,87,91,107],"involved":[47],"characteristics":[50],"their":[52,324],"using":[55],"an":[56],"vitro":[58],"incubation":[59],"system":[60],"[\u2077\u00b3As]-label":[62],"proteins.":[63,284],"Arsenite":[64,173],"was":[65,74,129,272,287],"bound":[69],"attributed":[75],"affinity":[78,143,264],"for":[79,235,241],"protein":[80,301],"sulfhydryls.":[81],"Ammonium":[82],"sulfate":[83],"precipitation":[84],"revealed":[88],"three":[89],"arsenite-binding":[90,224,254],"(AsBPs)":[92],"molecular":[94],"weights":[95],"100K,":[97],"450K":[98,127,219,258,270,292],">2000K":[100],"as":[101,182],"determined":[102],"by":[103,188,261,275,294,308],"size-exclusion":[104],"chromatography.":[105],"Similar-sized":[106],"were":[108],"observed":[109],"cytosol":[112,232,242],"prepared":[113],"from":[114],"a":[115,146,239,303],"rabbit":[116],"[\u2077\u00b3As]-arsenite":[118],"vivo.":[120],"arsenite":[124,203],"AsBP":[128,259,271,293],"most":[130],"stable":[131],"further":[133],"work":[134],"focused":[135],"purification":[138],"characterization.":[140],"Trivalent":[141],"chromatography":[144,197],"suggested":[145],"dithiol-like":[147],"site.":[149],"Amino":[150],"acid":[151,208,250,281],"composition":[152],"indicated":[153,302],"less":[154],"than":[155],"0.5":[156],"mol%":[157],"cysteine":[158],"residues":[159],"implied":[161],"that":[162,202,268],"other":[163],"thiol-containing":[164],"functional":[165,194],"groups":[166,216],"may":[167],"be":[168,211],"used":[169],"complex":[171],"arsenite.":[172],"inhibits":[174],"enzymes":[175,237],"contain":[177],"protein-bound":[178],"lipoic":[179,207,249,280],"acid,":[180],"such":[181],"pyruvate":[183,227],"dehydrogenase":[184,230],"\u03b1-ketoglutarate":[186,229],"dehydrogenase,":[187,228],"presumably":[189],"these":[192,321],"dithiol":[193,215],"groups.":[195,251],"Thin-layer":[196],"mass":[199],"spectrometry":[200],"established":[201],"complexes":[204],"reduced":[206],"might":[210],"similar":[214],"AsBP.":[220],"Comparison":[221],"activities":[225],"showed":[233,267],"increases":[234],"but":[238],"decrease":[240],"after":[243],"pre-treatment":[244],"NADH":[246],"reduces":[248],"However,":[252],"activity":[255],"increased":[260],"26-fold.":[262],"Antibody":[263],"studies,":[265],"though,":[266],"not":[273],"recognized":[274],"antibodies":[276],"cross-react":[278],"epitopes":[282],"Preparative":[285],"SDS-PAGE":[286],"successful":[288],"purifying":[290],"over":[295],"2300-fold.":[296],"Attempts":[297],"at":[298],"sequencing":[299,325],"blocked":[304],"N-terminus.":[305],"Chemical":[306],"cleavage":[307],"cyanogen":[309],"bromide":[310],"produced":[311],"two":[312],"fragments":[313,322],"approximately":[315],"60K":[316],"53K.":[318],"Isolation":[319],"continuing.":[327]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
