{"id":"https://openalex.org/W78738688","doi":null,"title":"Metabolic and behavioral responses to acute and chronic morphine","display_name":"Metabolic and behavioral responses to acute and chronic morphine","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W78738688","mag":"78738688"},"language":"en","primary_location":{"id":"mag:78738688","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/52/supplement_1/1199","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007290530","display_name":"Joseph Carri\u00f3n","orcid":"https://orcid.org/0000-0003-2275-3196","observed_orcids":["https://orcid.org/0000-0003-2275-3196"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Carri\u00f3n","raw_affiliation_strings":["2Department of Molecular Biology, City College of New York, New York, NY"],"raw_orcid":"https://orcid.org/0000-0003-2275-3196","affiliations":[{"raw_affiliation_string":"2Department of Molecular Biology, City College of New York, New York, NY","institution_ids":["https://openalex.org/I125687163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074091728","display_name":"Amanda Talan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Talan","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006596388","display_name":"Stergiani Agorastos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stergiani Agorastos","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040062989","display_name":"Alexandra Aarons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Aarons","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108103997","display_name":"Sandra Scherrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Scherrer","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112031383","display_name":"Stephen L. Dewey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Dewey","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108631669","display_name":"Krishna J. Patel","orcid":"https://orcid.org/0009-0009-7963-0518","observed_orcids":["https://orcid.org/0009-0009-7963-0518"]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Patel","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010358690","display_name":"Christina K. Veith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Veith","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050396241","display_name":"Wynne K. Schiffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wynne K. Schiffer","raw_affiliation_strings":["1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Laboratory for Behavioral and Molecular Neuroimaging, North Shore - LIJ Health System, Manhasset, NY","institution_ids":["https://openalex.org/I1302444339"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00408232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":null,"first_page":"1199","last_page":"1199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.0625,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acute-drug-exposure","display_name":"acute drug exposure","score":0.5849999785423279},{"id":"https://openalex.org/keywords/chronic-drug-exposure","display_name":"chronic drug exposure","score":0.7559999823570251},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fdg-uptake","display_name":"FDG uptake","score":0.7080000042915344},{"id":"https://openalex.org/keywords/regional-cerebral-metabolism","display_name":"regional brain metabolism","score":0.7829999923706055},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8180000185966492},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.949999988079071},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.628000020980835},{"id":"https://openalex.org/keywords/withdrawal-behavior","display_name":"withdrawal behavior","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.8101283311843872},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.7871242165565491},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7793149948120117},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.6367125511169434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6174545288085938},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.559108316898346},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5093303918838501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4615033268928528},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.44298475980758667},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4397626221179962},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3882451355457306},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33581864833831787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32803064584732056},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2899637222290039},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.17621415853500366},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1003682017326355},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.07318168878555298}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:78738688","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/52/supplement_1/1199","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362722736","https://openalex.org/W2088622169","https://openalex.org/W4221023816","https://openalex.org/W2287067809","https://openalex.org/W3161529521","https://openalex.org/W4255696942","https://openalex.org/W2004148396","https://openalex.org/W1975031380","https://openalex.org/W2796945900","https://openalex.org/W2036258040"],"abstract_inverted_index":{"1199":[0],"Objectives":[2],"Rodents":[4],"administered":[5,77],"sub-chronic":[6,241],"escalating":[7,127],"doses":[8,128],"of":[9,40,100,115,129,148,208],"morphine":[10,76,93,116,130,157,163,225],"exhibit":[11],"decreases":[12,187],"in":[13,17,43,79,168,174,185,188,191,215,218,231],"relative":[14],"glucose":[15],"metabolism":[16,45,87],"the":[18,169,175,236],"frontal":[19,176],"cortex,":[20],"thalamus,":[21],"and":[22,36,48,55,67,141,145,155,171,178,198,251],"cerebellum.":[23],"These":[24],"region-specific":[25],"changes":[26,214,230],"are":[27],"consistent":[28],"with":[29,33,126,212],"human":[30],"behaviors":[31],"associated":[32],"drug":[34,50],"use":[35,51],"addiction.":[37],"The":[38],"role":[39],"regional":[41,213],"differences":[42],"brain":[44,86],"between":[46],"acute":[47],"chronic":[49,92],"to":[52,89,120,135],"disease":[53],"progression":[54],"treatment":[56,183,226],"has":[57,81],"not":[58],"been":[59],"fully":[60],"considered,":[61],"if":[62],"at":[63],"all.":[64],"Using":[65],"18FDG":[66],"Micro":[68],"Positron":[69],"Emission":[70],"Tomography":[71],"(MicroPET),":[72],"we":[73],"show":[74],"that":[75,234],"acutely":[78],"rodents":[80,90],"an":[82],"opposite":[83],"effect":[84],"on":[85],"compared":[88],"undergoing":[91],"exposure.":[94],"Methods":[96],"Two":[98],"groups":[99],"adult":[101],"male":[102],"rats":[103],"received":[104,111],"serial":[105],"FDG":[106,137,166,189,216,232],"PET":[107],"scan.":[108],"Group":[109,122],"1":[110],"a":[112],"single":[113],"dose":[114],"(10mg/kg)":[117],"15min":[118],"prior":[119],"FDG.":[121],"2":[123],"was":[124],"treated":[125],"for":[131],"14":[132],"days":[133,147],"(10mg/kg":[134],"42.5mg/kg).":[136],"scans":[138],"occurred":[139],"baseline":[140],"after":[142,156,240],"1,":[143],"7,":[144],"21":[146],"withdrawal.":[149],"Behavioral":[150,206],"measures":[151,207],"were":[152],"obtained":[153],"during":[154],"treatment.":[158,242],"Results":[160],"Acutely,":[162],"significantly":[164],"increased":[165],"uptake":[167,173,190,217,233],"striatum":[170],"decreased":[172],"cortex":[177],"cerebellum":[179],"(see":[180],"Figure).":[181],"Sub-chronic":[182],"resulted":[184],"persistent":[186],"both":[192],"cortical":[193],"(frontal,":[194],"parietal,":[195],"temporal":[196],"cortices)":[197],"subcortical":[199],"structures":[200],"(deep":[201],"cerebellar":[202],"nuclei,":[203],"striatum,":[204],"thalamus).":[205],"withdrawal":[209],"severity":[210],"correlated":[211],"these":[219],"regions.":[220],"Conclusions":[222],"Acute":[224],"causes":[227],"regionally":[228],"specific":[229],"parallel":[235],"lasting":[237],"decrements":[238],"observed":[239],"Research":[244],"Support":[245],"Supported":[247],"by":[248],"DOD":[249],"PR02620":[250],"NIH":[252],"R01-DA0252":[253]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}