{"id":"https://openalex.org/W78722479","doi":"https://doi.org/10.1007/978-3-642-41199-1_22","title":"\u03b2-Arrestins: Regulatory Role and Therapeutic Potential in Opioid and Cannabinoid Receptor-Mediated Analgesia","display_name":"\u03b2-Arrestins: Regulatory Role and Therapeutic Potential in Opioid and Cannabinoid Receptor-Mediated Analgesia","publication_year":2013,"publication_date":"2013-11-05","ids":{"openalex":"https://openalex.org/W78722479","doi":"https://doi.org/10.1007/978-3-642-41199-1_22","mag":"78722479","pmid":"https://pubmed.ncbi.nlm.nih.gov/24292843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4804701"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-41199-1_22","doi":"https://doi.org/10.1007/978-3-642-41199-1_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-41199-1_22","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W398449947","display_name":"Arrestins - Pharmacology and Therapeutic Potential"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4804701","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055663249","display_name":"Kirsten M. Raehal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kirsten M. Raehal","raw_affiliation_strings":["The Scripps Research Institute, 130 Scripps Way #2A2, Jupiter, FL, 33458, USA, kirsten.raehal@pharma.com","The Scripps Research Institute, 130 Scripps Way #2A2, Jupiter, FL, 33458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, 130 Scripps Way #2A2, Jupiter, FL, 33458, USA, kirsten.raehal@pharma.com","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"The Scripps Research Institute, 130 Scripps Way #2A2, Jupiter, FL, 33458, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003815380","display_name":"Laura Bohn","orcid":"https://orcid.org/0000-0002-6474-8179","observed_orcids":["https://orcid.org/0000-0002-6474-8179"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura M. Bohn","raw_affiliation_strings":["The Scripps Research Institute, 130 Scripps Way #2A2, Jupiter, FL, 33458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, 130 Scripps Way #2A2, Jupiter, FL, 33458, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055663249"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":4.3538,"has_fulltext":false,"cited_by_count":154,"citation_normalized_percentile":{"value":0.94200212,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"219","issue":null,"first_page":"427","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-arrestin","display_name":"beta-arrestin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cannabinoid-analgesia","display_name":"cannabinoid analgesia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/biased-agonists","display_name":"biased agonists","score":0.8100000023841858},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.6869999766349792},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6539999842643738},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.7171780467033386},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.6830064654350281},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6243324279785156},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5815584063529968},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5730282068252563},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5212584137916565},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.4863618016242981},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.4787837266921997},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.4610781669616699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41640377044677734},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4113260805606842},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39997413754463196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2317807674407959},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12297207117080688},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.08343586325645447}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/978-3-642-41199-1_22","doi":"https://doi.org/10.1007/978-3-642-41199-1_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-41199-1_22","pdf_url":null,"source":{"id":"https://openalex.org/S2754143784","display_name":"Handbook of experimental pharmacology","issn_l":"0171-2004","issn":["0171-2004","1865-0325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Experimental Pharmacology","raw_type":"book-chapter"},{"id":"pmid:24292843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24292843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of experimental pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4804701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4804701","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Handb Exp Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4804701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4804701","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Handb Exp Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8224619403","display_name":"Synthesis and Evaluation of Functionally Biased Opioid Analgesics","funder_award_id":"R01DA033073","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000860848","display_name":"Novel Probes of the Kappa Opioid Receptor: Chemistry, Pharmacology, and Biology","funder_award_id":"R01DA031927","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W193979248","https://openalex.org/W1486226554","https://openalex.org/W1502369243","https://openalex.org/W1542482240","https://openalex.org/W1570565174","https://openalex.org/W1627321564","https://openalex.org/W1655589213","https://openalex.org/W1748186601","https://openalex.org/W1768678470","https://openalex.org/W1776637350","https://openalex.org/W1899328101","https://openalex.org/W1909076506","https://openalex.org/W1969835418","https://openalex.org/W1973925937","https://openalex.org/W1974654730","https://openalex.org/W1978783734","https://openalex.org/W1982359556","https://openalex.org/W1985819300","https://openalex.org/W1986170864","https://openalex.org/W1986674232","https://openalex.org/W1987067051","https://openalex.org/W1992910810","https://openalex.org/W1996098098","https://openalex.org/W1996214244","https://openalex.org/W1999808927","https://openalex.org/W2000104695","https://openalex.org/W2001721435","https://openalex.org/W2004120139","https://openalex.org/W2008748109","https://openalex.org/W2008935385","https://openalex.org/W2010284869","https://openalex.org/W2012652285","https://openalex.org/W2015087988","https://openalex.org/W2016784502","https://openalex.org/W2018123394","https://openalex.org/W2020166794","https://openalex.org/W2021216066","https://openalex.org/W2023469635","https://openalex.org/W2023812185","https://openalex.org/W2030751218","https://openalex.org/W2030777873","https://openalex.org/W2039360003","https://openalex.org/W2039772414","https://openalex.org/W2040668587","https://openalex.org/W2041853416","https://openalex.org/W2043287085","https://openalex.org/W2046455851","https://openalex.org/W2046550691","https://openalex.org/W2047548557","https://openalex.org/W2049819003","https://openalex.org/W2051746492","https://openalex.org/W2055457973","https://openalex.org/W2059421922","https://openalex.org/W2060207881","https://openalex.org/W2061189186","https://openalex.org/W2064318896","https://openalex.org/W2067538890","https://openalex.org/W2068061691","https://openalex.org/W2070535004","https://openalex.org/W2071955997","https://openalex.org/W2071984610","https://openalex.org/W2073411542","https://openalex.org/W2077680700","https://openalex.org/W2081226239","https://openalex.org/W2081474383","https://openalex.org/W2083071923","https://openalex.org/W2085819418","https://openalex.org/W2086139880","https://openalex.org/W2089746884","https://openalex.org/W2104191533","https://openalex.org/W2105080299","https://openalex.org/W2106607972","https://openalex.org/W2107153432","https://openalex.org/W2109083102","https://openalex.org/W2109568827","https://openalex.org/W2110045591","https://openalex.org/W2112924959","https://openalex.org/W2115931493","https://openalex.org/W2117762969","https://openalex.org/W2119581183","https://openalex.org/W2120352672","https://openalex.org/W2126041445","https://openalex.org/W2127424619","https://openalex.org/W2128103663","https://openalex.org/W2135598278","https://openalex.org/W2135970284","https://openalex.org/W2139953381","https://openalex.org/W2142766161","https://openalex.org/W2150585461","https://openalex.org/W2156007283","https://openalex.org/W2161820607","https://openalex.org/W2163804310","https://openalex.org/W2165671231","https://openalex.org/W2170556110","https://openalex.org/W2171950624","https://openalex.org/W2309568282","https://openalex.org/W2791114118","https://openalex.org/W4296309414","https://openalex.org/W4406025314"],"related_works":["https://openalex.org/W2911658232","https://openalex.org/W2519838443","https://openalex.org/W2982315497","https://openalex.org/W7135525976","https://openalex.org/W2601467964","https://openalex.org/W7160843181","https://openalex.org/W4407842923","https://openalex.org/W2912905713","https://openalex.org/W2156480657","https://openalex.org/W2006888214"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":63},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
