{"id":"https://openalex.org/W78721892","doi":null,"title":"Modulation of human natural killer cytotoxicity by influenza virus and its subunit protein.","display_name":"Modulation of human natural killer cytotoxicity by influenza virus and its subunit protein.","publication_year":1984,"publication_date":"1984-08-01","ids":{"openalex":"https://openalex.org/W78721892","mag":"78721892","pmid":"https://pubmed.ncbi.nlm.nih.gov/6746000","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454638"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454638","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026424262","display_name":"Samim Ali","orcid":"https://orcid.org/0009-0004-0070-526X","observed_orcids":["https://orcid.org/0009-0004-0070-526X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Ali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111659155","display_name":"Robert C. Rees","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R C Rees","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109218953","display_name":"JOHN S. OXFORD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Oxford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.29,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.48396895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"52","issue":"4","first_page":"687","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nk-cell-inhibition","display_name":"NK cell inhibition","score":0.6480000019073486},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8729888200759888},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7364963293075562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6375443935394287},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5733999013900757},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.5301305651664734},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5118457674980164},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.4588741362094879},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.4532814621925354},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4439394176006317},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4230871796607971},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.41316843032836914},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3487898111343384},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3479522466659546},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.305976539850235},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2998518645763397},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.27529996633529663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14630553126335144}],"mesh":[{"descriptor_ui":"D001963","descriptor_name":"Bromelains","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006389","descriptor_name":"Hemagglutinins, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1454638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:6746000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6746000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:78721892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6746000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1482804511","https://openalex.org/W1514352368","https://openalex.org/W1550686374","https://openalex.org/W1555496457","https://openalex.org/W1577819536","https://openalex.org/W1678679338","https://openalex.org/W1970981770","https://openalex.org/W1975381946","https://openalex.org/W1978887438","https://openalex.org/W1979535495","https://openalex.org/W1990707920","https://openalex.org/W2000636798","https://openalex.org/W2032384716","https://openalex.org/W2044221687","https://openalex.org/W2045299745","https://openalex.org/W2046609186","https://openalex.org/W2046669246","https://openalex.org/W2048770506","https://openalex.org/W2059168808","https://openalex.org/W2066103055","https://openalex.org/W2074877369","https://openalex.org/W2084093106","https://openalex.org/W2116775583","https://openalex.org/W2117735867","https://openalex.org/W2129022731","https://openalex.org/W2143143209","https://openalex.org/W2147787458","https://openalex.org/W2161277705","https://openalex.org/W2162056981","https://openalex.org/W2169998037","https://openalex.org/W2337332253","https://openalex.org/W4313310658"],"related_works":["https://openalex.org/W2013684768","https://openalex.org/W2401347179","https://openalex.org/W2151207103","https://openalex.org/W2059168808","https://openalex.org/W2118688654","https://openalex.org/W2122361533","https://openalex.org/W2592409864","https://openalex.org/W194317015","https://openalex.org/W3123664230","https://openalex.org/W2442013075"],"abstract_inverted_index":{"The":[0,137],"influence":[1],"of":[2,38,47,69,115,126,140,155,183,200],"intact":[3],"influenza":[4,30,54,93,189,208],"virus":[5,31,55,151,190],"and":[6,99,132,153,192,219],"purified":[7,53],"detergent":[8,131],"solubilized":[9],"haemagglutinin":[10],"(HA)":[11],"subunits":[12],"from":[13],"these":[14,135],"viruses":[15],"on":[16],"human":[17,142,156,169],"natural":[18],"killer":[19],"(NK)":[20],"cell":[21,49,117,225],"activity":[22,59,201],"was":[23,42,145,195,202],"examined.":[24],"Effector":[25,89],"cells":[26,79,90,144,159,175,194,218],"incubated":[27],"with":[28,44,160],"whole":[29],"for":[32,83,95,104,162,198],"18":[33,107],"hr":[34],"initiated":[35],"the":[36,45,67,70,180],"production":[37],"alpha":[39,170],"interferon":[40,171],"which":[41,210,220],"associated":[43],"enhancement":[46],"NK":[48,58,116,173,224],"activity.":[50,226],"In":[51],"contrast,":[52],"HA":[56,94,127,161,191],"suppressed":[57],"in":[60,101,134,204],"a":[61,196],"dose-dependent":[62],"manner,":[63],"when":[64,74],"added":[65],"at":[66],"onset":[68],"cytotoxicity":[71,84,118,139],"assay,":[72],"or":[73,129],"used":[75],"to":[76,81,92,106,110,123,148,166,168,176,179,215,217,222],"pre-treated":[77],"effector":[78,143,158,174,193],"prior":[80,165],"assay":[82],"against":[85],"K562":[86],"target":[87],"cells.":[88],"exposed":[91],"90":[96,163],"min,":[97,164],"washed":[98],"re-incubated":[100],"fresh":[102],"medium":[103],"up":[105],"hr,":[108],"failed":[109,221],"regain":[111],"their":[112],"cytotoxicity.":[113],"Suppression":[114],"could":[119],"not":[120,212],"be":[121,213],"ascribed":[122],"direct":[124,186],"toxicity":[125],"preparations":[128],"residual":[130],"preservative":[133],"preparations.":[136],"augmented":[138],"activated":[141],"also":[146],"susceptible":[147],"suppression":[149,199],"by":[150],"HA,":[152,209],"pretreatment":[154],"PBL":[157],"exposure":[167],"caused":[172],"become":[177],"refractive":[178],"enhancing":[181],"effects":[182],"HIFN.":[184],"That":[185],"interaction":[187],"between":[188],"requirement":[197],"shown":[203],"experiments":[205],"using":[206],"Bromelain-released":[207],"would":[211],"expected":[214],"bind":[216],"suppress":[223]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}