{"id":"https://openalex.org/W78627753","doi":"https://doi.org/10.1159/000468327","title":"Are There Schizophrenics for Whom Drugs May be Unnecessary or Contraindicated?","display_name":"Are There Schizophrenics for Whom Drugs May be Unnecessary or Contraindicated?","publication_year":2017,"publication_date":"2017-08-11","ids":{"openalex":"https://openalex.org/W78627753","doi":"https://doi.org/10.1159/000468327","mag":"78627753","pmid":"https://pubmed.ncbi.nlm.nih.gov/352976"},"language":"en","primary_location":{"id":"doi:10.1159/000468327","doi":"https://doi.org/10.1159/000468327","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000468327","pdf_url":null,"source":{"id":"https://openalex.org/S2764984609","display_name":"International Pharmacopsychiatry","issn_l":"0020-8272","issn":["0020-8272","2504-2580"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Pharmacopsychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111636850","display_name":"Maurice B. Rappaport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802195347","display_name":"Langley Porter Psychiatric Hospital and Clinics","ror":"https://ror.org/014gzk937","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802195347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice Rappaport","raw_affiliation_strings":["Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2802195347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005553832","display_name":"H. Kenneth Hopkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802195347","display_name":"Langley Porter Psychiatric Hospital and Clinics","ror":"https://ror.org/014gzk937","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802195347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Kenneth Hopkins","raw_affiliation_strings":["Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2802195347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113617675","display_name":"Karyl M. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802195347","display_name":"Langley Porter Psychiatric Hospital and Clinics","ror":"https://ror.org/014gzk937","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802195347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karyl Hall","raw_affiliation_strings":["Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2802195347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081027341","display_name":"Teodoro Belleza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2802195347","display_name":"Langley Porter Psychiatric Hospital and Clinics","ror":"https://ror.org/014gzk937","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802195347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teodoro Belleza","raw_affiliation_strings":["Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Langley Porter Neuropsychiatric Institute, University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2802195347"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110566496","display_name":"Julian Silverman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julian Silverman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2424,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.8604585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"2","first_page":"100","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13944","display_name":"Psychiatric care and mental health services","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8199999928474426},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/unmedicated-patients","display_name":"unmedicated patients","score":0.5889999866485596},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hospital-readmission","display_name":"hospital readmission","score":0.8140000104904175},{"id":"https://openalex.org/keywords/community-functioning","display_name":"community functioning","score":0.8230000138282776},{"id":"https://openalex.org/keywords/young-men","display_name":"young men","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8617379665374756},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.8614686727523804},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6862285733222961},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.6848447322845459},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.534337043762207},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5233975052833557},{"id":"https://openalex.org/C2780187144","wikidata":"https://www.wikidata.org/wiki/Q41112","display_name":"Paranoid schizophrenia","level":3,"score":0.46210774779319763},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4412711262702942},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3443039357662201},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.23834863305091858},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1701415777206421},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07167932391166687},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002746","descriptor_name":"Chlorpromazine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002746","descriptor_name":"Chlorpromazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010352","descriptor_name":"Patient Dropouts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000468327","doi":"https://doi.org/10.1159/000468327","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000468327","pdf_url":null,"source":{"id":"https://openalex.org/S2764984609","display_name":"International Pharmacopsychiatry","issn_l":"0020-8272","issn":["0020-8272","2504-2580"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Pharmacopsychiatry","raw_type":"journal-article"},{"id":"pmid:352976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/352976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International pharmacopsychiatry","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2364169058","https://openalex.org/W2139685490","https://openalex.org/W7100642758","https://openalex.org/W125108601","https://openalex.org/W156634810","https://openalex.org/W7097755352","https://openalex.org/W2324754031","https://openalex.org/W2013657997","https://openalex.org/W2102138443","https://openalex.org/W2368908471"],"abstract_inverted_index":{"This":[0],"study":[1,121],"reports":[2],"that":[3],"there":[4],"are":[5,112],"schizophrenics":[6],"who":[7,74],"do":[8],"relatively":[9],"well":[10],"long":[11],"term":[12],"without":[13],"the":[14,70,80,102,117,131],"routine":[15],"or":[16,49],"continuous":[17],"use":[18],"of":[19,105,122,133],"antipsychotic":[20,126],"medication.":[21],"Specially":[22],"selected":[23],"young":[24],"males":[25],"undergoing":[26],"an":[27,99],"acute":[28,106],"schizophrenic":[29,107],"episode":[30],"were":[31,43,75,87],"followed,":[32],"after":[33],"hospitalization,":[34],"for":[35,119],"up":[36],"to":[37,46,84,124],"three":[38],"years.":[39],"While":[40],"hospitalized":[41],"they":[42],"assigned":[44],"randomly":[45],"either":[47],"placebo":[48],"chlorpromazine":[50,77],"treatment.":[51],"Many":[52],"unmedicated-while-in-hospital":[53],"patients":[54,73,108],"showed":[55],"greater":[56],"long-term":[57],"improvement,":[58],"less":[59],"pathology":[60],"at":[61],"follow-up,":[62],"fewer":[63],"rehospitalizations":[64],"and":[65,91],"better":[66],"overall":[67],"function":[68],"in":[69,79,130],"community":[71],"than":[72],"given":[76],"while":[78],"hospital.":[81],"Factors":[82],"related":[83],"post-hospital":[85],"outcome":[86],"good":[88],"premorbid":[89],"history":[90],"short-lived":[92],"paranoid":[93],"characteristics.":[94],"Considerations":[95],"which":[96],"may":[97],"have":[98],"effect":[100],"on":[101,110],"successful":[103],"management":[104],"not":[109],"medication":[111,127],"mentioned.":[113],"The":[114],"findings":[115],"underline":[116],"need":[118],"further":[120],"how":[123],"utilize":[125],"more":[128],"selectively":[129],"treatment":[132],"schizophrenia.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}