{"id":"https://openalex.org/W78568620","doi":null,"title":"[Modafinil and fatigue in multiple sclerosis].","display_name":"[Modafinil and fatigue in multiple sclerosis].","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W78568620","mag":"78568620","pmid":"https://pubmed.ncbi.nlm.nih.gov/15470583"},"language":"es","primary_location":{"id":"pmid:15470583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15470583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia (Barcelona, Spain)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079453563","display_name":"Neus T\u00e9llez","orcid":"https://orcid.org/0000-0003-4660-1621","observed_orcids":["https://orcid.org/0000-0003-4660-1621"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N T\u00e9llez","raw_affiliation_strings":["Unitat de Neuroimmunologia Cl\u00ednica, Hospital Universitari Vall d'Hebron, Barcelona. ntellez@vhebron.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Neuroimmunologia Cl\u00ednica, Hospital Universitari Vall d'Hebron, Barcelona. ntellez@vhebron.net","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031171090","display_name":"Xavier Montalb\u00e1n","orcid":"https://orcid.org/0000-0002-0098-9918","observed_orcids":["https://orcid.org/0000-0002-0098-9918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Montalb\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4237,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63451686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"8","first_page":"434","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modafinil","display_name":"modafinil","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.968999981880188},{"id":"https://openalex.org/keywords/wakefulness-promoting-agents","display_name":"wakefulness-promoting agents","score":0.9190000295639038},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.9179999828338623},{"id":"https://openalex.org/keywords/sustained-attention","display_name":"sustained attention","score":0.765999972820282},{"id":"https://openalex.org/keywords/alpha-oscillations","display_name":"alpha oscillations","score":0.621999979019165},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2780714222","wikidata":"https://www.wikidata.org/wiki/Q410441","display_name":"Modafinil","level":2,"score":0.998943030834198},{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.8235585689544678},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5972191095352173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5947999954223633},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.538666844367981},{"id":"https://openalex.org/C192769605","wikidata":"https://www.wikidata.org/wiki/Q1418914","display_name":"Vigilance (psychology)","level":2,"score":0.4246927499771118},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.32138097286224365},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32055145502090454},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30375802516937256},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30373644828796387},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2974105775356293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21273741126060486}],"mesh":[{"descriptor_ui":"D000077408","descriptor_name":"Modafinil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:15470583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15470583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia (Barcelona, Spain)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2023850801","https://openalex.org/W2126845735","https://openalex.org/W1975930259","https://openalex.org/W2073297721","https://openalex.org/W2766287719","https://openalex.org/W3210521871","https://openalex.org/W4254989814","https://openalex.org/W4400567569","https://openalex.org/W2127372885","https://openalex.org/W2138769035"],"abstract_inverted_index":{"Fatigue":[0],"is":[1,30,81,86,98,113,125],"one":[2],"of":[3,72,89,132,165],"the":[4,69,76,121,130,155],"most":[5],"frequent":[6],"and":[7,24,26,78,92,115,136,139,168,170],"disabling":[8],"symptoms":[9],"in":[10,37,48,64,150,177],"multiple":[11],"sclerosis":[12],"(MS)":[13],"patients.":[14],"This":[15],"symptom's":[16],"etiopathogenic":[17],"mechanism,":[18],"though":[19],"not":[20,99],"known,":[21,100],"seems":[22],"complex":[23],"multifactorial,":[25],"its":[27,94,116,166],"therapeutic":[28],"management":[29],"difficult.":[31],"Different":[32],"treatments":[33],"have":[34],"been":[35,51,56],"tested":[36],"recent":[38],"years,":[39],"but":[40],"a":[41,59,87,161],"weak":[42],"efficacy":[43,167],"that":[44,127],"may":[45],"be":[46],"limited":[47],"time":[49],"has":[50,55],"observed.":[52],"Recently,":[53],"modafinil":[54,73,128,149],"suggested":[57],"as":[58,160],"possible":[60],"treatment":[61],"for":[62],"fatigue":[63],"MS":[65,151],"patients,":[66],"although":[67,93],"nowadays,":[68],"only":[70],"use":[71],"approved":[74],"by":[75],"Food":[77],"Drug":[79],"Administration":[80],"narcolepsy.":[82],"Modafinil,":[83],"2-([difenilmetil]sulfinil),":[84],"acetamide":[85],"state":[88],"wakeness":[90],"promoter,":[91],"exact":[95],"action":[96,117],"mechanism":[97],"it":[101],"differs":[102],"from":[103],"other":[104],"central":[105],"nervous":[106],"system":[107],"stimulants":[108],"because":[109,164],"no":[110],"dopaminergic":[111],"activation":[112],"observed,":[114],"take":[118],"place":[119],"at":[120],"hypothalamic":[122],"level.":[123],"It":[124],"known":[126],"increases":[129],"proportion":[131],"high-frequency":[133],"alpha":[134],"waves":[135],"reduces":[137],"delta":[138],"theta":[140],"waves,":[141],"increasing":[142],"vigilance.":[143],"Although":[144],"few":[145],"studies":[146],"exist":[147],"on":[148],"patients":[152],"with":[153],"fatigue,":[154],"results":[156],"suggest":[157],"this":[158,178],"drug":[159],"promising":[162],"treatment,":[163],"safety,":[169],"should":[171],"encourage":[172],"us":[173],"to":[174],"continue":[175],"working":[176],"area.":[179]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
