{"id":"https://openalex.org/W78555771","doi":"https://doi.org/10.1016/b978-1-4832-8322-7.50075-3","title":"METHODS TO EVALUATE IN VIVO THE ACTIVITY OF GABA RECEPTOR AGONISTS","display_name":"METHODS TO EVALUATE IN VIVO THE ACTIVITY OF GABA RECEPTOR AGONISTS","publication_year":1978,"publication_date":"1978-01-01","ids":{"openalex":"https://openalex.org/W78555771","doi":"https://doi.org/10.1016/b978-1-4832-8322-7.50075-3","mag":"78555771"},"language":"en","primary_location":{"id":"doi:10.1016/b978-1-4832-8322-7.50075-3","doi":"https://doi.org/10.1016/b978-1-4832-8322-7.50075-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-1-4832-8322-7.50075-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Psychopharmacology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4247370854","display_name":"Neuro-Psychopharmacology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048825104","display_name":"Alessandro Guidotti","orcid":"https://orcid.org/0000-0003-4480-0010","observed_orcids":["https://orcid.org/0000-0003-4480-0010"]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. GUIDOTTI","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital Washington, D. C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital Washington, D. C","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048825104"],"corresponding_institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04521739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"439","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-receptor-agonists","display_name":"GABA agonists","score":0.9829999804496765},{"id":"https://openalex.org/keywords/muscimol","display_name":"muscimol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gaba-receptor-antagonists","display_name":"GABA receptor antagonists","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glycine-receptor-antagonists","display_name":"glycine receptor antagonists","score":0.9079999923706055},{"id":"https://openalex.org/keywords/convulsions","display_name":"convulsions","score":0.9020000100135803},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.8360000252723694},{"id":"https://openalex.org/keywords/picrotoxin","display_name":"picrotoxin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pargyline","display_name":"pargyline","score":0.9869999885559082},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibition","display_name":"monoamine oxidase inhibition","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2779324764","wikidata":"https://www.wikidata.org/wiki/Q416602","display_name":"Picrotoxin","level":4,"score":0.8227261304855347},{"id":"https://openalex.org/C2779188335","wikidata":"https://www.wikidata.org/wiki/Q412504","display_name":"Muscimol","level":4,"score":0.7765085697174072},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.603341281414032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6004031896591187},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.5904879570007324},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5822191834449768},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5253181457519531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4897046387195587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4734190106391907},{"id":"https://openalex.org/C79636183","wikidata":"https://www.wikidata.org/wiki/Q5512770","display_name":"GABA receptor antagonist","level":5,"score":0.457732230424881},{"id":"https://openalex.org/C2776674594","wikidata":"https://www.wikidata.org/wiki/Q306252","display_name":"GABA receptor","level":4,"score":0.4566251039505005},{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.4505192041397095},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.37736251950263977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2407064437866211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16080844402313232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15992772579193115}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-1-4832-8322-7.50075-3","doi":"https://doi.org/10.1016/b978-1-4832-8322-7.50075-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-1-4832-8322-7.50075-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Psychopharmacology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W617051113","https://openalex.org/W1582681335","https://openalex.org/W1975946135","https://openalex.org/W1976467195","https://openalex.org/W1980125444","https://openalex.org/W1985868885","https://openalex.org/W1986562254","https://openalex.org/W1994037589","https://openalex.org/W2024100507","https://openalex.org/W2028079792","https://openalex.org/W2031500844","https://openalex.org/W2035001553","https://openalex.org/W2059485890","https://openalex.org/W2059715331","https://openalex.org/W2067093690","https://openalex.org/W2074870180","https://openalex.org/W2237071195","https://openalex.org/W2440705866","https://openalex.org/W2529947513"],"related_works":["https://openalex.org/W1994037589","https://openalex.org/W2196714032","https://openalex.org/W2047750211","https://openalex.org/W2019727411","https://openalex.org/W2412500585","https://openalex.org/W2038674327","https://openalex.org/W2170917522","https://openalex.org/W1977458557","https://openalex.org/W1996360366","https://openalex.org/W25718160"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}