{"id":"https://openalex.org/W78527592","doi":null,"title":"A randomised study of ornidazole as a radiosensitiser in carcinoma of the cervix: long term results.","display_name":"A randomised study of ornidazole as a radiosensitiser in carcinoma of the cervix: long term results.","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W78527592","mag":"78527592","pmid":"https://pubmed.ncbi.nlm.nih.gov/8763898","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149986"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1522088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149986","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149986","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056701807","display_name":"Sait Okkan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S Okkan","raw_affiliation_strings":["Department of Radiation Oncology, Cerrahpasa Medical Faculty, University of Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Cerrahpasa Medical Faculty, University of Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064842045","display_name":"G\u00fcly\u00fcz Atkovar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Atkovar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049128531","display_name":"\u0130smet \u015eahinler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Sahinler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046812502","display_name":"S. Turkan","orcid":"https://orcid.org/0000-0002-0771-1644","observed_orcids":["https://orcid.org/0000-0002-0771-1644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Turkan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056886353","display_name":"Reha Uzel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Uzel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.00832625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"27","issue":null,"first_page":"S282","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ornidazole","display_name":"ornidazole","score":1.0},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/locally-advanced-cervical-cancer","display_name":"locally advanced cervical cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/intracavitary-radiotherapy","display_name":"intracavitary radiotherapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/local-tumor-control","display_name":"local tumor control","score":0.8450000286102295},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9430000185966492},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7639999985694885},{"id":"https://openalex.org/keywords/radiation-induced-complications","display_name":"radiation complications","score":0.5329999923706055},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2779668173","wikidata":"https://www.wikidata.org/wiki/Q2358146","display_name":"Ornidazole","level":2,"score":0.9795546531677246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8288841843605042},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.5869325995445251},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5390509963035583},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4920196235179901},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3498578369617462},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3331880569458008},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19211742281913757},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05396294593811035},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009950","descriptor_name":"Ornidazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009950","descriptor_name":"Ornidazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1522088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149986","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2149986","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149986","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer Suppl","raw_type":"Text"},{"id":"pmid:8763898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8763898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of cancer. Supplement","raw_type":"Clinical Trial"},{"id":"mag:78527592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8763898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1522088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149986","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1898209140","https://openalex.org/W1979344842","https://openalex.org/W1987186486","https://openalex.org/W1991907444","https://openalex.org/W1993019230","https://openalex.org/W2014501764","https://openalex.org/W2017880061","https://openalex.org/W2025983924","https://openalex.org/W2038252730","https://openalex.org/W2047232494","https://openalex.org/W2065627976","https://openalex.org/W2084612222","https://openalex.org/W2087604248","https://openalex.org/W2091774035","https://openalex.org/W2095876600","https://openalex.org/W2115146864","https://openalex.org/W2141639935","https://openalex.org/W2319463151","https://openalex.org/W2410435584","https://openalex.org/W2413610302","https://openalex.org/W2413665974","https://openalex.org/W2415921769","https://openalex.org/W2422876631"],"related_works":["https://openalex.org/W3093088124","https://openalex.org/W2087602058","https://openalex.org/W1965587670","https://openalex.org/W4255947646","https://openalex.org/W2377400239","https://openalex.org/W181451418","https://openalex.org/W1983108489","https://openalex.org/W1984205241","https://openalex.org/W7054803944","https://openalex.org/W2116444357"],"abstract_inverted_index":{"This":[0,64],"paper":[1],"presents":[2],"long-term":[3],"results":[4,148,178],"of":[5,9,18,23,33,128,132,164,188],"a":[6,12,31,93,162,165,182],"randomised":[7,27],"study":[8,136],"ornidazole":[10,117,151],"as":[11],"radiosensitiser":[13],"in":[14,54,81,96,116,185],"locally":[15],"advanced":[16],"carcinoma":[17],"the":[19,82,97,129,177,186],"cervix.":[20],"A":[21],"total":[22],"76":[24],"patients":[25,37,55],"were":[26,38,78,142],"and":[28,42,74,106,138,158,192],"followed-up":[29],"with":[30,40,59,168],"median":[32],"85":[34],"months.":[35],"All":[36],"treated":[39],"external":[41],"intracavitary":[43],"irradiation.":[44],"The":[45],"10":[46],"year":[47,71],"actuarial":[48,72],"local":[49,98,189],"control":[50,99,191],"rate":[51],"was":[52,66,92],"61%":[53],"receiving":[56],"ornidazole,":[57],"compared":[58],"50%":[60],"for":[61,119,181],"placebo":[62],"group.":[63],"difference":[65],"not":[67],"statistically":[68],"significant.":[69],"Ten":[70],"overall":[73],"disease-free":[75,107],"survival":[76,108],"rates":[77,109,141],"also":[79],"similar":[80],"two":[83],"treatment":[84],"groups.":[85],"Although,":[86],"when":[87],"analysed":[88],"by":[89],"stage,":[90],"there":[91],"significant":[94],"advantage":[95],"(54%":[100],"vs":[101,111],"15%;":[102],"P":[103,113],"=":[104,114],"0.044)":[105],"(37%":[110],"8%;":[112],"0.047)":[115],"group":[118],"stage":[120],"IIIB":[121],"cases,":[122],"its":[123],"implication":[124],"is":[125],"obscure":[126],"because":[127],"small":[130],"number":[131],"patients.":[133],"In":[134],"this":[135],"moderate":[137],"severe":[139],"complication":[140],"found":[143],"to":[144,153],"be":[145],"30%.":[146],"These":[147],"suggest":[149],"that":[150],"seems":[152],"have":[154],"relatively":[155,172],"weak":[156],"sensitisation":[157],"it":[159],"may":[160],"show":[161],"possibility":[163],"marginal":[166],"benefit":[167],"unconventional":[169],"irradiation":[170],"using":[171],"large":[173],"radiation":[174],"doses.":[175],"However,":[176],"are":[179],"insufficient":[180],"real":[183],"gain":[184],"probability":[187],"tumour":[190],"survival.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}