{"id":"https://openalex.org/W78523362","doi":null,"title":"A murine model of allergy caused by American cockroach (CR), Periplaneta americana.","display_name":"A murine model of allergy caused by American cockroach (CR), Periplaneta americana.","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W78523362","mag":"78523362","pmid":"https://pubmed.ncbi.nlm.nih.gov/19054933"},"language":"en","primary_location":{"id":"pmid:19054933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19054933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of allergy and immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051668237","display_name":"Nitat Sookrung","orcid":"https://orcid.org/0000-0002-7199-9435","observed_orcids":["https://orcid.org/0000-0002-7199-9435","https://orcid.org/0000-0002-2503-4288"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Nitat Sookrung","raw_affiliation_strings":["Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. sinsru@mahidol.ac.th"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. sinsru@mahidol.ac.th","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017119198","display_name":"Nitaya Indrawattana","orcid":"https://orcid.org/0000-0003-1571-528X","observed_orcids":["https://orcid.org/0000-0003-1571-528X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nitaya Indrawattana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064247998","display_name":"Anchalee Tungtrongchitr","orcid":"https://orcid.org/0009-0000-5743-2240","observed_orcids":["https://orcid.org/0009-0000-5743-2240","https://orcid.org/0000-0002-2503-4288","https://orcid.org/0000-0003-1995-4405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anchalee Tungtrongchitr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021764540","display_name":"Charan Karuhassuwan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charan Karuhassuwan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055049714","display_name":"Urai Chaisri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Urai Chaisri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001937106","display_name":"Wanpen Chaicumpa","orcid":"https://orcid.org/0000-0001-6973-8255","observed_orcids":["https://orcid.org/0000-0001-6973-8255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanpen Chaicumpa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2034,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.57758134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"2-3","first_page":"143","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periplaneta-americana","display_name":"Periplaneta americana","score":1.0},{"id":"https://openalex.org/keywords/murine-allergy-model","display_name":"murine allergy model","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cockroach-allergens","display_name":"cockroach allergens","score":0.7789999842643738},{"id":"https://openalex.org/keywords/eosinophilic-airway-inflammation","display_name":"eosinophilic airway inflammation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/serum-ige","display_name":"serum IgE","score":0.8679999709129333},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.7860000133514404},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.8019999861717224},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9750000238418579},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.7910000085830688},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2780625307","wikidata":"https://www.wikidata.org/wiki/Q264976","display_name":"Periplaneta","level":3,"score":0.8152520060539246},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.6874277591705322},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.6301387548446655},{"id":"https://openalex.org/C2780931586","wikidata":"https://www.wikidata.org/wiki/Q844270","display_name":"Ragweed","level":3,"score":0.6041238903999329},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5790538191795349},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5608378648757935},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5335529446601868},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.47349295020103455},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.4534083902835846},{"id":"https://openalex.org/C2777346155","wikidata":"https://www.wikidata.org/wiki/Q18123008","display_name":"Cockroach","level":2,"score":0.4499271810054779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44507771730422974},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2924540042877197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1625123918056488},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.14087152481079102},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000534","descriptor_name":"Alum Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007117","descriptor_name":"Immunization, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010526","descriptor_name":"Periplaneta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045424","descriptor_name":"Complex Mixtures","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D045424","descriptor_name":"Complex Mixtures","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19054933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19054933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of allergy and immunology","raw_type":"Journal Article"},{"id":"mag:78523362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19054933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W93816355","https://openalex.org/W1217204668","https://openalex.org/W1583081002","https://openalex.org/W1963833671","https://openalex.org/W1991774943","https://openalex.org/W2002416305","https://openalex.org/W2033232206","https://openalex.org/W2040182830","https://openalex.org/W2049420298","https://openalex.org/W2052571627","https://openalex.org/W2055797514","https://openalex.org/W2080133621","https://openalex.org/W2082906220","https://openalex.org/W2091459248","https://openalex.org/W2096016708","https://openalex.org/W2106454494","https://openalex.org/W2109971798","https://openalex.org/W2128635872","https://openalex.org/W2142652158","https://openalex.org/W2397697869","https://openalex.org/W2411778368","https://openalex.org/W2412538753"],"related_works":["https://openalex.org/W2367228344","https://openalex.org/W7016620514","https://openalex.org/W2058539330","https://openalex.org/W1998625131","https://openalex.org/W2120730395","https://openalex.org/W2055912972","https://openalex.org/W3148334700","https://openalex.org/W2994289971","https://openalex.org/W99485049","https://openalex.org/W1583081002"],"abstract_inverted_index":{"An":[0],"animal":[1],"model":[2,37,306],"resembling":[3,310],"the":[4,101,116,154,166,181,188,203,206,210,218,253,258,264,284,290,294,302],"human":[5,311],"immuno-pathological":[6],"features":[7],"of":[8,20,26,38,61,65,100,133,153,165,180,195,205,209,215,230,239,245,257,263,283,293,301,307],"CR":[9,14,77,102,189,219],"allergy":[10,15],"is":[11],"needed":[12],"for":[13],"research,":[16],"e.g.,":[17],"measuring":[18],"allergenicity":[19],"novel":[21],"allergens,":[22],"testing":[23],"immunotherapeutic":[24],"efficacies":[25],"drugs":[27],"and":[28,59,71,84,97,118,127,144,200,233,243,261],"vaccines.":[29],"In":[30],"this":[31],"study":[32],"we":[33],"develop":[34],"a":[35],"murine":[36,305],"American":[39],"CR,":[40],"P.":[41,66,308],"americana":[42,309],"allergy.":[43],"BALB/c":[44],"mice,":[45],"6":[46],"weeks":[47],"old,":[48],"were":[49,74,110,130],"individually":[50],"intraperitoneally":[51],"injected":[52],"with":[53],"three":[54],"doses":[55],"(days":[56],"0,":[57],"7":[58],"14)":[60],"alum":[62,95],"adjuvanted-crude":[63],"extract":[64,78,103,190],"americana.":[67],"On":[68],"days":[69],"21":[70],"23,":[72],"they":[73],"given":[75],"crude":[76],"in":[79,151,178,192,202,250],"PBS":[80,98],"intranasally":[81],"(10":[82,86],"microl)":[83],"aerosolically":[85],"ml)":[87],"via":[88],"an":[89],"air-pressure":[90],"nebulizer,":[91],"respectively.":[92],"Mice":[93],"received":[94],"alone":[96],"instead":[99],"served":[104],"as":[105,271],"non-allergenic":[106,167,254,265],"controls.":[107,207,255,291],"All":[108],"mice":[109,136,156,199,211,226,260],"bled":[111],"twenty":[112],"four":[113],"hours":[114],"after":[115],"nebulization":[117],"sacrificed.":[119],"Their":[120],"serum":[121,185,193],"samples,":[122],"broncho-alveolar":[123],"lavage":[124],"fluids":[125],"(BALF),":[126],"lung":[128],"tissues":[129],"collected.":[131],"BALF":[132,152],"all":[134,196,224],"allergen-treated":[135,182,225,259],"had":[137,227,267,280],"marked":[138,228],"cellular":[139],"infiltration":[140,175],"notably":[141],"neutrophils,":[142],"eosinophils":[143],"lymphocytes.":[145],"The":[146,173],"average":[147],"total":[148],"cell":[149],"count":[150],"allergenic":[155],"was":[157,176,314],"1.9":[158],"x":[159,170],"10(5)":[160],"cells/ml":[161],"which":[162],"out-numbered":[163],"those":[164,300],"controls":[168,266],"(8":[169],"10(4)":[171],"cells/ml).":[172],"eosinophil":[174],"pronounced":[177],"lungs":[179],"mice.":[183],"Specific":[184],"IgE":[186],"to":[187,217,252,289,299],"elevated":[191],"samples":[194],"allergen":[197,277],"treated":[198],"nil":[201],"sera":[204],"None":[208,256],"showed":[212],"detectable":[213,246],"level":[214,282],"IgG2a":[216],"extract.":[220],"RT-PCR":[221],"revealed":[222],"that":[223],"increase":[229,238],"IL-13,":[231],"IL-4":[232],"TNF-alpha":[234],"gene":[235,241,248,269,286],"expressions,":[236],"slight":[237],"IL-5":[240],"expression,":[242],"absence":[244],"IFN-gamma":[247],"expression":[249,270,287],"comparison":[251],"50%":[262],"IL-12":[268],"detected":[272],"by":[273],"RT-":[274],"PCR.":[275],"One":[276],"treated-mouse":[278],"(25%)":[279],"subpar":[281],"IL-18":[285],"compared":[288],"Results":[292],"quantitative":[295],"real-time":[296],"PCR":[297],"conformed":[298],"RT-PCR.":[303],"A":[304],"allergic":[312],"manifestations":[313],"successfully":[315],"developed.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}