{"id":"https://openalex.org/W78454140","doi":null,"title":"Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype.","display_name":"Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype.","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W78454140","mag":"78454140","pmid":"https://pubmed.ncbi.nlm.nih.gov/9344362"},"language":"en","primary_location":{"id":"pmid:9344362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9344362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016715548","display_name":"Geoffrey K. Aguirre","orcid":"https://orcid.org/0000-0002-4028-3100","observed_orcids":["https://orcid.org/0000-0002-4028-3100"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G D Aguirre","raw_affiliation_strings":["James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078087543","display_name":"Gregory M. Acland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G M Acland","raw_affiliation_strings":["James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111658380","display_name":"Maureen B. Maude","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M B Maude","raw_affiliation_strings":["James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004338167","display_name":"Robert E. Anderson","orcid":"https://orcid.org/0000-0001-5664-6968","observed_orcids":["https://orcid.org/0000-0001-5664-6968"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R E Anderson","raw_affiliation_strings":["James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3306,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.91175002,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"38","issue":"11","first_page":"2387","last_page":"407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8920000195503235},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8299999833106995},{"id":"https://openalex.org/keywords/plasma-lipid-levels","display_name":"plasma lipid levels","score":0.6060000061988831},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":0.7570000290870667},{"id":"https://openalex.org/keywords/electroretinography","display_name":"electroretinogram","score":0.6589999794960022},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.8604085445404053},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.6345988512039185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6227284669876099},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5790031552314758},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5688396692276001},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5181456804275513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48555561900138855},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.48025158047676086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34143003821372986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17304375767707825},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074242","descriptor_name":"Sunflower Oil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004042","descriptor_name":"Dietary Fats, Unsaturated","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005395","descriptor_name":"Fish Oils","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010938","descriptor_name":"Plant Oils","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9344362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9344362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:78454140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9344362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5509712900","display_name":"Second Messengers in the Retina","funder_award_id":"R01EY000871","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5652366295","display_name":"PROGRESSIVE ROD-CONE DEGENERATION: SYNTHESIS AND RENEWAL","funder_award_id":"R01EY001244","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1557455393","https://openalex.org/W1482319154","https://openalex.org/W7095353186","https://openalex.org/W2071190027","https://openalex.org/W10755661","https://openalex.org/W2002180241","https://openalex.org/W641745906","https://openalex.org/W139562477","https://openalex.org/W236543297","https://openalex.org/W2411643928"],"abstract_inverted_index":{"PURPOSE:":[0],"Results":[1],"of":[2,43,52,148,170,177,234,266,283,309,315,321],"a":[3,81,310,329],"previous":[4],"study":[5],"show":[6],"abnormal":[7,86],"plasma":[8,30,87,184,274],"lipids":[9],"in":[10,28,58,61,72,100,181,183,192,194,199,206,214,273,312,318,331],"progressive":[11],"rod-cone":[12],"degeneration":[13,173],"(prcd)-affected":[14],"dogs,":[15],"with":[16,251],"lower":[17,239],"docosahexaenoic":[18],"acid":[19,71,146],"(DHA;":[20],"22:6n-3)":[21],"and":[22,35,90,109,126,137,139,143,151,163,186,191,201,208,244,275,291],"cholesterol":[23],"levels":[24,89,223,246,288],"but":[25,217],"no":[26],"differences":[27],"other":[29],"fatty":[31,70,145,189,197,210],"acids,":[32],"lipids,":[33],"triglycerides,":[34],"fat-soluble":[36],"vitamins.":[37],"There":[38],"is":[39,56,66,296],"also":[40],"an":[41],"increase":[42],"the":[44,50,67,94,120,144,159,171,215,232,267,281,285,292,300,307,313,319,338],"DHA":[45,65,185,207,242,277,287,332],"precursor":[46],"22:5n-3,":[47],"so":[48],"that":[49,278],"ratio":[51],"22:5n-3":[53],"to":[54,104,118,167,270],"22:6n-3":[55,101],"higher":[57,222],"affected":[59,218,235,322],"than":[60],"normal":[62,127,200],"dogs.":[63,203],"Because":[64],"predominant":[68],"esterified":[69],"rod":[73,110,152],"outer":[74,111,153],"segment":[75,112,154],"(ROS)":[76],"phospholipids,":[77],"these":[78,245],"findings":[79,304],"suggest":[80],"possible":[82],"causal":[83],"association":[84],"between":[85],"lipid":[88],"retinal":[91,172,339],"degeneration.":[92],"In":[93,158,230],"current":[95],"study,":[96,161],"dietary":[97,252,301],"supplements":[98,133,179],"rich":[99],"were":[102,130,156,165,212],"used":[103,166],"determine":[105],"whether":[106],"plasma,":[107,149],"liver,":[108,150,216],"phospholipid":[113],"composition":[114,147],"can":[115],"be":[116,249,259,306,328],"altered":[117],"modify":[119],"prcd":[121,293],"disease":[122,255,294],"phenotype.":[123,174],"METHODS:":[124],"prcd-affected":[125,202],"control":[128],"dogs":[129,219,236],"given":[131],"DHA-enriched":[132,178,262],"for":[134],"short":[135],"(7-":[136],"25-day)":[138],"long":[140],"(21-week)":[141],"periods,":[142],"phospholipids":[155,317],"examined.":[157,229],"long-term":[160],"electroretinography":[162],"morphology":[164],"assess":[168],"modification":[169],"RESULTS:":[175],"Administration":[176],"resulted":[180],"increases":[182,205],"n-3":[187,209],"polyunsaturated":[188],"acids":[190,198,211],"decreases":[193],"some":[195],"n-6":[196],"Similar":[204],"observed":[213],"had":[220,237],"significantly":[221],"at":[224],"all":[225],"supplementation":[226],"time":[227],"points":[228],"contrast,":[231],"ROS":[233,286],"statistically":[238],"(approximately":[240],"20%)":[241],"levels,":[243],"could":[247,257,305,327],"not":[248,258,297],"increased":[250],"supplementation.":[253],"The":[254],"phenotype":[256,295],"modified":[260,298],"by":[261,299],"supplements.":[263],"CONCLUSIONS:":[264],"Regardless":[265],"sustained":[268],"three-":[269],"fourfold":[271],"elevation":[272],"liver":[276],"occurs":[279],"as":[280],"result":[282,308],"supplementation,":[284],"remain":[289],"unchanged,":[290],"manipulation.":[302],"These":[303],"reduction":[311,330],"synthesis":[314],"DHA-containing":[316],"retinas":[320],"dogs;":[323],"or,":[324],"alternatively,":[325],"there":[326],"uptake,":[333],"transport,":[334],"or":[335],"storage":[336],"within":[337],"pigment":[340],"epithelium-photoreceptor":[341],"complex.":[342]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
