{"id":"https://openalex.org/W783853081","doi":null,"title":"Multiple roles for the transcription factors Sox6 and jumonji in mouse hematopoiesis","display_name":"Multiple roles for the transcription factors Sox6 and jumonji in mouse hematopoiesis","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W783853081","mag":"783853081"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/195728","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195728","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016838563","display_name":"Drew T. Erickson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Drew T. Erickson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016838563"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox6","display_name":"SOX6","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/definitive-erythropoiesis","display_name":"definitive erythropoiesis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/erythroid-precursors","display_name":"erythroid precursors","score":0.6610000133514404},{"id":"https://openalex.org/keywords/erythrocyte-maturation","display_name":"erythrocyte maturation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.8479999899864197},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fetal-liver","display_name":"fetal liver","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.7487778663635254},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6604864001274109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6264101266860962},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5713403820991516},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.530471920967102},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.523807168006897},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5211358666419983},{"id":"https://openalex.org/C2780844101","wikidata":"https://www.wikidata.org/wiki/Q2380264","display_name":"Ineffective erythropoiesis","level":4,"score":0.4358447790145874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41954296827316284},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37207821011543274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18682825565338135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18378710746765137},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.17919760942459106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1601848006248474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1143769919872284}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/195728","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195728","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:783853081","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/195728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W65399366","https://openalex.org/W146857095","https://openalex.org/W195788402","https://openalex.org/W1503531691","https://openalex.org/W1511101472","https://openalex.org/W1518105110","https://openalex.org/W1562987667","https://openalex.org/W1570696801","https://openalex.org/W1664772138","https://openalex.org/W1866388848","https://openalex.org/W1887025767","https://openalex.org/W1928245765","https://openalex.org/W1937332911","https://openalex.org/W1945580731","https://openalex.org/W1949372270","https://openalex.org/W1952464171","https://openalex.org/W1964457403","https://openalex.org/W1964976079","https://openalex.org/W1966333151","https://openalex.org/W1967294655","https://openalex.org/W1969923067","https://openalex.org/W1969952153","https://openalex.org/W1975555336","https://openalex.org/W1977409466","https://openalex.org/W1978417129","https://openalex.org/W1979055697","https://openalex.org/W1980358100","https://openalex.org/W1980964000","https://openalex.org/W1981309824","https://openalex.org/W1981411229","https://openalex.org/W1981460612","https://openalex.org/W1986070439","https://openalex.org/W1990908376","https://openalex.org/W1992538495","https://openalex.org/W1995408331","https://openalex.org/W1998022943","https://openalex.org/W2000898869","https://openalex.org/W2000961686","https://openalex.org/W2003501719","https://openalex.org/W2006808125","https://openalex.org/W2009706285","https://openalex.org/W2010233594","https://openalex.org/W2012866178","https://openalex.org/W2013246689","https://openalex.org/W2016364197","https://openalex.org/W2017510215","https://openalex.org/W2017596496","https://openalex.org/W2017764753","https://openalex.org/W2019270922","https://openalex.org/W2021388708","https://openalex.org/W2021516648","https://openalex.org/W2022584463","https://openalex.org/W2023070796","https://openalex.org/W2023257193","https://openalex.org/W2026688799","https://openalex.org/W2026836635","https://openalex.org/W2028879093","https://openalex.org/W2030566923","https://openalex.org/W2031125174","https://openalex.org/W2035415315","https://openalex.org/W2035515932","https://openalex.org/W2038658579","https://openalex.org/W2045934620","https://openalex.org/W2046516822","https://openalex.org/W2046889725","https://openalex.org/W2047121990","https://openalex.org/W2048365283","https://openalex.org/W2048442464","https://openalex.org/W2049848159","https://openalex.org/W2050641883","https://openalex.org/W2051740914","https://openalex.org/W2052988833","https://openalex.org/W2054324871","https://openalex.org/W2054643318","https://openalex.org/W2063927773","https://openalex.org/W2065854842","https://openalex.org/W2068053372","https://openalex.org/W2071992278","https://openalex.org/W2075598942","https://openalex.org/W2077981176","https://openalex.org/W2078331675","https://openalex.org/W2078782153","https://openalex.org/W2079309819","https://openalex.org/W2081026902","https://openalex.org/W2081769332","https://openalex.org/W2083839201","https://openalex.org/W2083882414","https://openalex.org/W2086514698","https://openalex.org/W2086551569","https://openalex.org/W2087386268","https://openalex.org/W2091755990","https://openalex.org/W2092319413","https://openalex.org/W2093205649","https://openalex.org/W2093321309","https://openalex.org/W2097066119","https://openalex.org/W2101960837","https://openalex.org/W2102047286","https://openalex.org/W2102106534","https://openalex.org/W2103619902","https://openalex.org/W2114805956","https://openalex.org/W2115908301","https://openalex.org/W2118299921","https://openalex.org/W2118945682","https://openalex.org/W2124908646","https://openalex.org/W2132070371","https://openalex.org/W2132996826","https://openalex.org/W2134304007","https://openalex.org/W2135445817","https://openalex.org/W2142303705","https://openalex.org/W2142362473","https://openalex.org/W2142395982","https://openalex.org/W2145023430","https://openalex.org/W2145202322","https://openalex.org/W2145909370","https://openalex.org/W2147629941","https://openalex.org/W2150409084","https://openalex.org/W2154657324","https://openalex.org/W2156415745","https://openalex.org/W2157187112","https://openalex.org/W2158827548","https://openalex.org/W2160183383","https://openalex.org/W2163168560","https://openalex.org/W2167253880","https://openalex.org/W2273701402","https://openalex.org/W2275335767","https://openalex.org/W2313717564","https://openalex.org/W2319577868","https://openalex.org/W2333732916","https://openalex.org/W2403899338","https://openalex.org/W2409724684","https://openalex.org/W7048614030"],"related_works":["https://openalex.org/W2091110453","https://openalex.org/W1980964000","https://openalex.org/W921303660","https://openalex.org/W2047121990","https://openalex.org/W2160252424","https://openalex.org/W2095424454","https://openalex.org/W7100623835","https://openalex.org/W7070379520","https://openalex.org/W6977605401","https://openalex.org/W6977385539"],"abstract_inverted_index":{"Sox6,":[0],"a":[1,140,160,186,193,225,253,312,329],"member":[2],"of":[3,14,21,76,97,99,110,143,189,214,233,259,267,282,319],"the":[4,12,108,117,211,230,256,280,316,333],"Sox":[5],"transcription":[6,182,195],"factor":[7,196],"family,":[8],"is":[9,150,192,208,277,324],"essential":[10],"for":[11,152,272,279],"silencing":[13],"epsilon-y-globin":[15],"gene":[16],"expression":[17,74,98,296],"in":[18,44,47,78,101,124,128,145,167,197,210,220,274,301,315,332,339],"definitive":[19,147],"erythropoiesis":[20,148],"mice":[22,28,40,58,66,87,120,216,288],"and":[23,82,90,132,149,176,200,239,244,303,322],"humans.":[24],"Homozygous":[25],"Sox6":[26,45,135,157,250,273,310],"null":[27],"are":[29,42,298],"neonatal":[30],"lethal,":[31],"precluding":[32],"analysis":[33],"at":[34],"later":[35],"stages.":[36],"We":[37,203],"created":[38],"adult":[39,63,119,146],"that":[41,206,224,249,265,309,326],"deficient":[43],"specifically":[46],"hematopoietic":[48,292,335],"tissues,":[49],"by":[50,164],"transplanting":[51],"embryonic":[52],"liver":[53,213],"stem":[54,69,92,293],"cells":[55,70,93,127,222],"from":[56],"Sox6-deficient":[57,215,291,340],"into":[59],"lethally-irradiated":[60],"congenic":[61],"wild-type":[62,89],"mice.":[64,341],"The":[65,95],"receiving":[67,88],"mutant":[68,112],"(mutant-engrafted)":[71],"showed":[72,121],"high":[73],"levels":[75,297],"epsilon-y":[77,100,144,166],"bone":[79,129,304],"marrow,":[80,130],"spleen":[81,131],"circulating":[83,102],"blood":[84,103,302],"compared":[85],"to":[86,137,252],"heterozygous":[91],"(control-engrafted).":[94],"level":[96],"was":[104],"directly":[105],"correlated":[106],"with":[107,169,290],"percentage":[109],"successful":[111],"donor":[113],"cell":[114,174,336],"engraftment.":[115],"Additionally,":[116],"mutant-engrafted":[118],"an":[122],"increase":[123],"erythroid":[125,201],"precursor":[126],"blood.":[133],"Thus,":[134],"continues":[136],"function":[138],"as":[139,172,185],"major":[141,313],"regulator":[142],"required":[151,278],"normal":[153],"erythrocyte":[154],"maturation.":[155],"Moreover,":[156],"may":[158],"provide":[159],"novel":[161],"therapeutic":[162],"target":[163,188],"reactivating":[165],"patients":[168],"hemoglobinopathies":[170],"such":[171],"sickle":[173],"anemia":[175],"beta-thalassemia.We":[177],"have":[178],"also":[179],"identified":[180],"another":[181],"factor,":[183],"jumonji,":[184,234],"downstream":[187],"Sox6.":[190],"Jumonji":[191],"crtitical":[194],"neural,":[198],"cardiac":[199],"development.":[202],"report":[204],"here":[205],"jumonji":[207,295,320,327],"over-expressed":[209],"fetal":[212],"(p100H/p100H).":[217],"Transfection":[218],"assays":[219,247],"H2.35":[221],"reveal":[223],"~1.6-kb":[226],"genomic":[227],"fragment,":[228],"including":[229],"5'":[231],"UTR":[232],"contains":[235],"both":[236],"promoter":[237],"activity":[238],"Sox6-mediated":[240,283],"repression.":[241,285],"Chromatin":[242],"immunoprecipitation":[243],"electromobility":[245],"shift":[246],"demonstrate":[248,308],"binds":[251],"region":[254,276],"within":[255],"second":[257],"exon":[258],"jumonji.":[260],"Further":[261],"transfection":[262],"analyses":[263],"confirm":[264],"one":[266],"five":[268],"putative":[269],"binding":[270],"sites":[271],"this":[275],"majority":[281],"transcriptional":[284],"In":[286],"irradiated":[287],"engrafted":[289],"cells,":[294],"significantly":[299],"elevated":[300],"marrow.":[305],"These":[306],"results":[307],"plays":[311,328],"role":[314,331],"direct":[317],"repression":[318],"transcription,":[321],"it":[323],"likely":[325],"cell-autonomous":[330],"subsequent":[334],"phenotype":[337],"seen":[338]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}