{"id":"https://openalex.org/W782552913","doi":"https://doi.org/10.3844/ajmsp.2015.1.3","title":"The Food Additives Nitrite and Nitrate and Microbiological Safety of Food Products","display_name":"The Food Additives Nitrite and Nitrate and Microbiological Safety of Food Products","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W782552913","doi":"https://doi.org/10.3844/ajmsp.2015.1.3","mag":"782552913"},"language":"en","primary_location":{"id":"doi:10.3844/ajmsp.2015.1.3","doi":"https://doi.org/10.3844/ajmsp.2015.1.3","is_oa":true,"landing_page_url":"https://doi.org/10.3844/ajmsp.2015.1.3","pdf_url":"https://thescipub.com/pdf/ajmsp.2015.1.3.pdf","source":{"id":"https://openalex.org/S4210175733","display_name":"Current Research in Microbiology","issn_l":"1948-982X","issn":["1948-982X","1948-9838"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://thescipub.com/pdf/ajmsp.2015.1.3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074523392","display_name":"Stefanie M\u00fcller-Herbst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie M\u00fcller-Herbst","raw_affiliation_strings":["Chair for Microbial Ecology , Technical University Munich , Germany","ZIEL-Institute for Food and Health , Technical University Munich , Germany","Technical University Munich#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair for Microbial Ecology , Technical University Munich , Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"ZIEL-Institute for Food and Health , Technical University Munich , Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Technical University Munich#TAB#","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062191094","display_name":"Anna M\u00fchlig","orcid":"https://orcid.org/0009-0001-8278-6494","observed_orcids":["https://orcid.org/0009-0001-8278-6494"]},"institutions":[{"id":"https://openalex.org/I4210147723","display_name":"Max Rubner Institut","ror":"https://ror.org/045gmmg53","country_code":"DE","type":"government","lineage":["https://openalex.org/I2801963157","https://openalex.org/I4210147723"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna M\u00fchlig","raw_affiliation_strings":["Department of Microbiology and Biotechnology , MRI , Federal Research Institute of Nutrition and Food , Germany","Technical University Munich#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Biotechnology , MRI , Federal Research Institute of Nutrition and Food , Germany","institution_ids":["https://openalex.org/I4210147723"]},{"raw_affiliation_string":"Technical University Munich#TAB#","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014523665","display_name":"Jan Kabisch","orcid":"https://orcid.org/0000-0002-5956-1772","observed_orcids":["https://orcid.org/0000-0002-5956-1772"]},"institutions":[{"id":"https://openalex.org/I4210147723","display_name":"Max Rubner Institut","ror":"https://ror.org/045gmmg53","country_code":"DE","type":"government","lineage":["https://openalex.org/I2801963157","https://openalex.org/I4210147723"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Kabisch","raw_affiliation_strings":["Department of Microbiology and Biotechnology , MRI , Federal Research Institute of Nutrition and Food , Germany","Federal Research Institute of Nutrition and Food"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Biotechnology , MRI , Federal Research Institute of Nutrition and Food , Germany","institution_ids":["https://openalex.org/I4210147723"]},{"raw_affiliation_string":"Federal Research Institute of Nutrition and Food","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030219174","display_name":"Rohtraud Pichner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201850948","display_name":"Fulda University of Applied Sciences","ror":"https://ror.org/041bz9r75","country_code":"DE","type":"education","lineage":["https://openalex.org/I201850948"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rohtraud Pichner","raw_affiliation_strings":["Chair for Microbial Ecology , Technical University Munich , Germany","ZIEL-Institute for Food and Health , Technical University Munich , Germany","Fulda,University of Applied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair for Microbial Ecology , Technical University Munich , Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"ZIEL-Institute for Food and Health , Technical University Munich , Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Fulda,University of Applied Sciences","institution_ids":["https://openalex.org/I201850948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063596187","display_name":"Siegfried Scherer","orcid":"https://orcid.org/0000-0002-0394-9890","observed_orcids":["https://orcid.org/0000-0002-0394-9890"]},"institutions":[{"id":"https://openalex.org/I201850948","display_name":"Fulda University of Applied Sciences","ror":"https://ror.org/041bz9r75","country_code":"DE","type":"education","lineage":["https://openalex.org/I201850948"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Siegfried Scherer","raw_affiliation_strings":["Department of Nutritional, Food and Consumer Sciences , Fulda University of Applied Sciences , Germany","Technical University Munich#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional, Food and Consumer Sciences , Fulda University of Applied Sciences , Germany","institution_ids":["https://openalex.org/I201850948"]},{"raw_affiliation_string":"Technical University Munich#TAB#","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2883,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77806527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10900","display_name":"Listeria monocytogenes in Food Safety","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nitrate","display_name":"nitrate","score":0.9819999933242798},{"id":"https://openalex.org/keywords/curing-salts","display_name":"curing salts","score":0.8119999766349792},{"id":"https://openalex.org/keywords/raw-sausage","display_name":"raw sausage","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hurdle-technology","display_name":"hurdle technology","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pathogenic-bacteria","display_name":"pathogenic bacteria","score":0.75},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/nitrosamines","display_name":"nitrosamines","score":0.734000027179718},{"id":"https://openalex.org/keywords/nitrate-uptake","display_name":"nitrate uptake","score":0.3490000069141388},{"id":"https://openalex.org/keywords/dietary-nitrate","display_name":"dietary nitrate","score":0.5509999990463257},{"id":"https://openalex.org/keywords/food-additives","display_name":"food additives","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.9429868459701538},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.8331048488616943},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.7992910146713257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.762697696685791},{"id":"https://openalex.org/C67031304","wikidata":"https://www.wikidata.org/wiki/Q274579","display_name":"Preservative","level":2,"score":0.6516454219818115},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.5835971236228943},{"id":"https://openalex.org/C2909531343","wikidata":"https://www.wikidata.org/wiki/Q173514","display_name":"Food Preservatives","level":3,"score":0.5692740082740784},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.5641575455665588},{"id":"https://openalex.org/C132976073","wikidata":"https://www.wikidata.org/wiki/Q2991861","display_name":"Curing (chemistry)","level":2,"score":0.5312134027481079},{"id":"https://openalex.org/C2777176278","wikidata":"https://www.wikidata.org/wiki/Q557828","display_name":"Starter","level":2,"score":0.49545180797576904},{"id":"https://openalex.org/C139145706","wikidata":"https://www.wikidata.org/wiki/Q189567","display_name":"Food additive","level":2,"score":0.4392626881599426},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1590765118598938},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3844/ajmsp.2015.1.3","doi":"https://doi.org/10.3844/ajmsp.2015.1.3","is_oa":true,"landing_page_url":"https://doi.org/10.3844/ajmsp.2015.1.3","pdf_url":"https://thescipub.com/pdf/ajmsp.2015.1.3.pdf","source":{"id":"https://openalex.org/S4210175733","display_name":"Current Research in Microbiology","issn_l":"1948-982X","issn":["1948-982X","1948-9838"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3844/ajmsp.2015.1.3","doi":"https://doi.org/10.3844/ajmsp.2015.1.3","is_oa":true,"landing_page_url":"https://doi.org/10.3844/ajmsp.2015.1.3","pdf_url":"https://thescipub.com/pdf/ajmsp.2015.1.3.pdf","source":{"id":"https://openalex.org/S4210175733","display_name":"Current Research in Microbiology","issn_l":"1948-982X","issn":["1948-982X","1948-9838"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5666999816894531}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325145","display_name":"Forschungskreis der Ern\u00e4hrungsindustrie","ror":"https://ror.org/00mgycb86"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W782552913.pdf","grobid_xml":"https://content.openalex.org/works/W782552913.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1579261512","https://openalex.org/W1753664082","https://openalex.org/W1971704566","https://openalex.org/W1974765277","https://openalex.org/W2023673526","https://openalex.org/W2042451018","https://openalex.org/W2070781405","https://openalex.org/W2075825096","https://openalex.org/W2095925400","https://openalex.org/W2112713268","https://openalex.org/W2114325309","https://openalex.org/W2123732460","https://openalex.org/W2326005541","https://openalex.org/W2741450715","https://openalex.org/W4242485817"],"related_works":["https://openalex.org/W7097742657","https://openalex.org/W4235920222","https://openalex.org/W7218134825","https://openalex.org/W1978065356","https://openalex.org/W4297693000","https://openalex.org/W2381647282","https://openalex.org/W7205669252","https://openalex.org/W4416040606","https://openalex.org/W1997003405","https://openalex.org/W4285680694"],"abstract_inverted_index":{"In":[0,916],"Germany,":[1],"raw":[2,39,55,209,288,304,458,478,504,544,613,749,756,993,1032],"sausages":[3,210,479,545,757],"are":[4,58,146,307,364,461,635],"typically":[5],"produced":[6],"according":[7],"to":[8,12,120,176,207,219,271,287,319,334,379,394,398,404,542,557,622,637,673,840,846,901,925,936,970,1037,1070,1080],"a":[9,62,170,236,311,406,558,577,778,803,819,841,864,867,894,928,973,1020,1040,1071],"technology":[10,15],"referred":[11],"as":[13,132,136,138,412,414,416],"hurdle":[14],"(Leistner,":[16],"2000).":[17],"The":[18,126,303,930,956,1062],"combination":[19,815],"of":[20,30,61,71,76,83,87,96,101,128,159,180,201,222,239,242,248,255,265,276,283,339,348,357,385,389,452,471,494,503,511,526,551,566,580,583,587,593,601,660,736,738,760,762,773,818,837,848,863,888,896,932,943,989,1003,1027,1050,1057,1064,1074,1084,1092],"several":[21,418,428,501,623,689],"stressful":[22],"conditions":[23,834,893],"should":[24],"successfully":[25],"inhibit":[26,272,353],"growth":[27,273,354,470,491,508,590,659,1024],"and":[28,65,98,107,130,155,228,274,327,355,437,492,497,509,533,591,632,702,722,728,927,1014,1025,1086],"survival":[29,275,356,493,510,592,1026],"pathogenic":[31,358,455],"bacteria,":[32],"which":[33,634,806],"can":[34,767,909,1044],"be":[35,165,177,570,638,768,782,899,1045],"regularly":[36],"found":[37],"in":[38,152,293,427,457,474,500,644,654,675,742,746,755,814,985,991,1022,1030,1047],"pork":[40],"or":[41,79,93,105,191,203,285,554],"beef":[42],"material":[43],"(Mataragas":[44],"et":[45,49,142,259,434,440,481,529,646,664,708,712,874,953],"al.,":[46,50,143,260,435,441,482,530,647,665,709,713,875,954],"2008;":[47],"Rhoades":[48],"2009).":[51,261,714],"Hurdles":[52],"applied":[53],"during":[54,157,679],"sausage":[56,289,305,459,614,994],"fermentation":[57,615],"the":[59,77,81,85,94,99,115,122,160,184,196,199,208,220,223,229,240,263,266,280,294,314,321,329,336,340,346,365,373,386,399,422,449,507,512,517,524,552,563,567,581,584,598,609,639,696,699,703,719,723,758,763,771,774,785,799,835,913,917,986,992,1001,1011,1015,1031,1048,1055,1058,1075,1082,1089,1093],"appearance":[60],"competitive":[63],"flora":[64],"product":[66,78,568,995,1059,1076],"acidification":[67,883,964,981,1073],"by":[68,74,80,90,114,523,770,860],"fermentation,":[69],"reduction":[70,86,550],"water":[72],"activity":[73],"drying":[75],"addition":[82,95,100,200,264,282,347],"salt,":[84],"oxygen":[88],"tension":[89],"vacuum":[91],"packaging":[92],"ascorbate":[97],"preservatives":[102],"like":[103,625],"sorbate":[104],"nitrite":[106,131,148,190,204,284,349,380,453,468,489,527,555,588,602,619,704,744,801,825,838,897,926,945,990,1012,1052,1085],"nitrate":[108,116,129,192,202,286,553],"curing":[109,193,205,226,230,267,350,547],"salts.":[110,194],"Nitrate":[111],"is":[112,150,169,174,269,291,402,539,595,620,670,683,752,793,798,884,923,965,982,996,1035,1060],"converted":[113,621,900,924],"reducing":[117],"starter":[118,518,1066],"cultures":[119,519,1067],"nitrite,":[121],"actual":[123,640],"inhibitory":[124,387,423,450,585,599,641,941,987,1042],"compound.":[125],"use":[127,1063],"additives":[133,326,391],"has":[134,211,651,946],"positive":[135,213,237],"well":[137,690],"negative":[139,182],"aspects":[140],"(Cammack":[141],"1999).":[144,648],"Disadvantages":[145],"that":[147,156,173,401,447,467,488,560,656,686,754,780,791,797,831,847,881,962,1039,1068],"itself":[149],"toxic":[151],"high":[153],"concentrations":[154,1053],"heating":[158],"products":[161,188,290,460],"carcinogenic":[162],"nitrosamines":[163],"might":[164,392,789,898],"formed.":[166],"Furthermore":[167],"it":[168,217,485,538,650,682,687,792,828,878,1034],"food":[171,325],"additive":[172],"required":[175],"labeled.":[178],"Because":[179],"these":[181,390,739],"aspects,":[183],"health-conscious":[185],"consumer":[186],"wants":[187],"without":[189,546],"On":[195],"other":[197,330,775],"hand,":[198,316,331],"salt":[206,268,351],"also":[212,234,671],"side":[214],"effects,":[215],"e.g.,":[216,253,431],"contributes":[218],"development":[221],"typical":[224],"red":[225],"color":[227],"flavor.":[231],"Several":[232],"studies":[233,419,446],"suggest":[235],"impact":[238,586],"uptake":[241],"dietary":[243],"nitrate,":[244],"especially":[245],"via":[246],"consummation":[247],"vegetables,":[249],"on":[250,328,425,454,589,603,608,811,1010],"human":[251],"health,":[252],"lowering":[254],"blood":[256],"pressure":[257],"(Hord":[258],"Furthermore,":[262,484],"thought":[270],"unwanted":[277],"bacteria.":[278],"Therefore,":[279,537,597,877],"restricted":[281],"allowed":[292],"European":[295],"Union":[296],"for":[297,805,822,950],"conservation":[298],"purposes":[299],"(EU":[300],"regulation":[301],"1333/2008).":[302],"manufacturers":[306],"now":[308],"faced":[309],"with":[310,718,816],"dilemma.":[312],"One":[313],"one":[315,761],"they":[317,332],"have":[318,333],"address":[320],"consumers":[322],"concern":[323],"about":[324],"guarantee":[335],"microbiological":[337,564,1090],"safety":[338,565,1091],"products.":[341],"Open":[342],"questions":[343],"are:":[344],"Does":[345],"indeed":[352,983,1018],"bacteria?":[359],"And":[360],"if":[361],"yes,":[362],"what":[363],"molecular":[366,610],"mechanisms":[367],"behind":[368],"this":[369],"observation?":[370],"How":[371],"do":[372],"pathogens":[374,426,594],"adapt":[375],"their":[376,396],"transcriptional":[377,812],"profile":[378],"stress?":[381],"A":[382,549],"better":[383],"understanding":[384,579],"effect":[388,424,451,600,887,942,968,988,1043],"help":[393,1079],"reduce":[395,1081],"amount":[397,400,1083],"needed":[403],"receive":[405],"microbiologically":[407],"safe":[408],"product:":[409],"As":[410,667],"much":[411],"necessary,":[413],"little":[415],"possible.While":[417],"already":[420],"described":[421,949],"meat":[429],"products,":[430],"ham":[432],"(Horsch":[433],"2014)":[436],"Frankfurters":[438],"(Jackson":[439],"2011),":[442],"scientifically":[443],"based":[444],"systematic":[445],"describe":[448],"bacteria":[456,515],"rare.":[462],"It":[463,751],"was":[464,486,520,606,829,857,879],"reported":[465],"recently,":[466],"inhibits":[469,490,658],"Salmonella":[472],"Typhimurium":[473,605,662,669,960,1029],"short":[475],"ripened":[476],"spreadable":[477,748],"(M\u00fchlig":[480,873],"2014a).":[483],"shown":[487,653],"Staphylococcus":[495],"aureus":[496],"Listeria":[498],"monocytogenes":[499],"types":[502],"sausages,":[505,1033],"whilst":[506],"lactic":[513],"acid":[514,922,1005],"from":[516,958],"not":[521,540,684,731,794,966,998],"influenced":[522],"presence":[525,836,1049],"(Kabisch":[528],"2012":[531],"(German)":[532],"own":[534],"unpublished":[535],"data).":[536],"recommended":[541],"produce":[543],"salt.":[548],"concentration":[556,559,1013],"still":[561,1087],"warrants":[562],"would":[569],"an":[571,575,733,823,906,940,967,979],"alternative.":[572],"For":[573],"such":[574,978],"approach,":[576],"deeper":[578],"effectiveness":[582],"required.":[596],"S.":[604,661,668,959,1028],"studied":[607],"level.":[611],"During":[612],"under":[616,832,852],"acidic":[617,833,853,892],"conditions,":[618],"derivatives,":[624],"nitrous":[626,902,921,1004],"acid,":[627,905],"peroxynitrite,":[628],"Nitric":[629],"Oxide":[630],"(NO)":[631],"others,":[633],"supposed":[636],"agents":[642],"(reviewed":[643],"Cammack":[645],"Indeed,":[649],"been":[652,948],"vitro,":[655],"NO":[657,674,692,764,795],"(Park":[663],"2011).":[666],"exposed":[672],"its":[676],"natural":[677],"environment":[678],"host":[680],"colonization,":[681],"surprising":[685],"produces":[688],"characterized":[691],"detoxification":[693,765],"systems,":[694,777],"namely":[695],"flavohemoglobin":[697],"(HmpA),":[698],"flavorubredoxin":[700],"(NorV)":[701],"reductase,":[705],"NrfA":[706],"(Arkenberg":[707],"2011;":[710],"Prior":[711],"However,":[715],"challenge":[716],"assays":[717],"wild":[720],"type":[721],"deletion":[724,759],"mutants":[725],"\u2206hmpA,":[726],"\u2206norV":[727],"\u2206nrfA":[729],"did":[730],"indicate":[732,961],"essential":[734],"function":[735],"any":[737],"systems":[740,766],"(alone)":[741,796],"withstanding":[743],"stress":[745],"short-ripened":[747],"sausages.":[750],"possible,":[753],"compensated":[769],"expression":[772],"two":[776],"hypothesis":[779,804,856],"cannot":[781],"disproven":[783],"at":[784],"moment.":[786],"Another":[787],"explanation":[788],"be,":[790],"antibacterial":[800,886],"derivative,":[802],"further":[807,858],"indications":[808],"exist.":[809],"Based":[810],"data":[813],"screening":[817],"mutant":[820,865],"library":[821],"acidified":[824,889,944],"sensitive":[826,869],"phenotype,":[827],"speculated":[830],"leads":[839,935,1069],"decreased":[842],"intracellular":[843,882,937,963,980],"pH":[844,868,1056],"compared":[845],"cells":[849],"grown":[850],"only":[851],"stress.":[854],"This":[855],"confirmed":[859],"fluorescence":[861],"measurements":[862],"expressing":[866],"GFP":[870],"variant":[871],"(EGFP)":[872],"2014b).":[876],"concluded":[880],"another":[885],"nitrite.":[890],"Under":[891],"fraction":[895],"acid.":[903],"Nitrous":[904],"uncharged":[907],"molecule,":[908],"then":[910],"diffuse":[911],"across":[912],"bacterial":[914],"membrane.":[915],"near":[918],"neutral":[919],"cytoplasm,":[920],"proton.":[929],"release":[931],"free":[933],"protons":[934],"acidification.":[938],"Such":[939],"first":[947],"yeasts":[951],"(Mortensen":[952],"2008).":[955],"observations":[957],"specific":[969],"yeasts,":[971],"but":[972],"more":[974],"general":[975],"mechanism.":[976],"Whether":[977],"involved":[984],"currently":[997],"known.":[999],"If":[1000],"formation":[1002],"(an":[1006],"equilibrium":[1007],"reaction,":[1008],"depending":[1009],"pH),":[1016],"however,":[1017],"plays":[1019],"role":[1021],"inhibiting":[1023],"tempting":[1036],"speculate,":[1038],"similar":[1041],"observed":[1046],"lower":[1051],"when":[1054],"lowered.":[1061],"alternative":[1065],"faster":[1072],"could":[1077],"therefore":[1078],"warranting":[1088],"product.":[1094]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
