{"id":"https://openalex.org/W78238253","doi":null,"title":"The NMDA Receptor and Alcohol Addiction","display_name":"The NMDA Receptor and Alcohol Addiction","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W78238253","mag":"78238253"},"language":"en","primary_location":{"id":"mag:78238253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21204417/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008613169","display_name":"Dorit Ron A","orcid":"https://orcid.org/0000-0001-5161-967X","observed_orcids":["https://orcid.org/0000-0001-5161-967X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dorit Ron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100384673","display_name":"Jun Wang","orcid":"https://orcid.org/0000-0002-0085-4722","observed_orcids":["https://orcid.org/0000-0002-0085-4722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0085-4722","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1171,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.4267214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9340000152587891},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ethanol-tolerance","display_name":"ethanol tolerance","score":0.7279999852180481},{"id":"https://openalex.org/keywords/withdrawal","display_name":"withdrawal","score":0.7770000100135803},{"id":"https://openalex.org/keywords/craving","display_name":"craving","score":0.875},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nmda-receptor-modulators","display_name":"NMDA receptor modulators","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.8607751131057739},{"id":"https://openalex.org/C2779541405","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Craving","level":3,"score":0.7541826963424683},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6774835586547852},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.6278471350669861},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5283839106559753},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5254606008529663},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5146173238754272},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.47872257232666016},{"id":"https://openalex.org/C2994524651","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol addiction","level":3,"score":0.4720362424850464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.342806339263916},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2964441478252411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19846123456954956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10362610220909119},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0758608877658844}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:78238253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21204417/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W53392061","https://openalex.org/W92838330","https://openalex.org/W99057588","https://openalex.org/W1495846936","https://openalex.org/W1522236910","https://openalex.org/W1555529117","https://openalex.org/W1831370527","https://openalex.org/W1884136121","https://openalex.org/W1912081453","https://openalex.org/W1940069389","https://openalex.org/W1955563271","https://openalex.org/W1964028781","https://openalex.org/W1967139082","https://openalex.org/W1969811315","https://openalex.org/W1970584427","https://openalex.org/W1970642402","https://openalex.org/W1971330591","https://openalex.org/W1974324553","https://openalex.org/W1976179462","https://openalex.org/W1976373179","https://openalex.org/W1976490606","https://openalex.org/W1978249390","https://openalex.org/W1979383722","https://openalex.org/W1980158916","https://openalex.org/W1981808197","https://openalex.org/W1982138808","https://openalex.org/W1983807711","https://openalex.org/W1984649085","https://openalex.org/W1984956928","https://openalex.org/W1985047996","https://openalex.org/W1985180181","https://openalex.org/W1987579856","https://openalex.org/W1987681890","https://openalex.org/W1990581763","https://openalex.org/W1992093536","https://openalex.org/W1994164398","https://openalex.org/W1994662713","https://openalex.org/W1994728700","https://openalex.org/W1994989418","https://openalex.org/W1995334423","https://openalex.org/W1997568797","https://openalex.org/W1997663774","https://openalex.org/W1998347917","https://openalex.org/W2001629507","https://openalex.org/W2002376565","https://openalex.org/W2003683375","https://openalex.org/W2006541920","https://openalex.org/W2006952262","https://openalex.org/W2009313943","https://openalex.org/W2010074472","https://openalex.org/W2011830495","https://openalex.org/W2015063702","https://openalex.org/W2015207248","https://openalex.org/W2015218924","https://openalex.org/W2017253439","https://openalex.org/W2017341242","https://openalex.org/W2019196831","https://openalex.org/W2026683726","https://openalex.org/W2028101732","https://openalex.org/W2029676141","https://openalex.org/W2030756376","https://openalex.org/W2031311825","https://openalex.org/W2031742561","https://openalex.org/W2033577975","https://openalex.org/W2034351812","https://openalex.org/W2039252406","https://openalex.org/W2039408868","https://openalex.org/W2039497914","https://openalex.org/W2042377944","https://openalex.org/W2042646500","https://openalex.org/W2042757454","https://openalex.org/W2044081332","https://openalex.org/W2045165595","https://openalex.org/W2047517404","https://openalex.org/W2047676891","https://openalex.org/W2049511526","https://openalex.org/W2049746655","https://openalex.org/W2053073122","https://openalex.org/W2054647522","https://openalex.org/W2054749214","https://openalex.org/W2056778894","https://openalex.org/W2057451897","https://openalex.org/W2057831654","https://openalex.org/W2058250644","https://openalex.org/W2058889143","https://openalex.org/W2059968271","https://openalex.org/W2060255370","https://openalex.org/W2062225909","https://openalex.org/W2063169639","https://openalex.org/W2063248367","https://openalex.org/W2064910783","https://openalex.org/W2065906875","https://openalex.org/W2065921500","https://openalex.org/W2066912649","https://openalex.org/W2067939795","https://openalex.org/W2068003692","https://openalex.org/W2068253249","https://openalex.org/W2072721148","https://openalex.org/W2073537077","https://openalex.org/W2074079341","https://openalex.org/W2076054717","https://openalex.org/W2078167209","https://openalex.org/W2078327610","https://openalex.org/W2078334052","https://openalex.org/W2079615996","https://openalex.org/W2080574826","https://openalex.org/W2084200679","https://openalex.org/W2085049245","https://openalex.org/W2085912953","https://openalex.org/W2086008492","https://openalex.org/W2089076553","https://openalex.org/W2090520944","https://openalex.org/W2092156269","https://openalex.org/W2095472109","https://openalex.org/W2096346638","https://openalex.org/W2097934194","https://openalex.org/W2099222699","https://openalex.org/W2103789944","https://openalex.org/W2105913617","https://openalex.org/W2106537388","https://openalex.org/W2110724392","https://openalex.org/W2112093116","https://openalex.org/W2118926295","https://openalex.org/W2119453026","https://openalex.org/W2122485724","https://openalex.org/W2125273810","https://openalex.org/W2129301099","https://openalex.org/W2131958615","https://openalex.org/W2132971431","https://openalex.org/W2135104877","https://openalex.org/W2136314637","https://openalex.org/W2141604604","https://openalex.org/W2141757671","https://openalex.org/W2144724143","https://openalex.org/W2148389554","https://openalex.org/W2150106592","https://openalex.org/W2151791677","https://openalex.org/W2154521977","https://openalex.org/W2160630552","https://openalex.org/W2164014355","https://openalex.org/W2170085655","https://openalex.org/W2211425881","https://openalex.org/W2272575763","https://openalex.org/W2316627855","https://openalex.org/W2405169759","https://openalex.org/W2415689892","https://openalex.org/W2420811878","https://openalex.org/W2424649994","https://openalex.org/W4234185783"],"related_works":["https://openalex.org/W1495702170","https://openalex.org/W2478631220","https://openalex.org/W172178508","https://openalex.org/W2432767933","https://openalex.org/W2015207248","https://openalex.org/W113736404","https://openalex.org/W2127770680","https://openalex.org/W7095562123","https://openalex.org/W2558817386","https://openalex.org/W2110260727"],"abstract_inverted_index":{"Alcohol":[0],"addiction":[1],"is":[2,20,52,58],"a":[3,59],"costly":[4],"and":[5,28,44,46,68,81,99,103],"detrimental":[6],"chronic":[7],"relapsing":[8],"disorder,":[9],"characterized":[10],"by":[11],"compulsive":[12],"alcohol":[13,63],"use":[14,116],"despite":[15],"the":[16,56,66,97,101,114,126],"negative":[17],"consequences;":[18],"it":[19,51],"thought":[21],"to":[22,124],"be":[23],"associated":[24],"with":[25],"aberrant":[26],"learning":[27,45],"memory":[29,47],"processes":[30],"[1,2].":[31],"The":[32],"NMDA-type":[33],"glutamate":[34],"receptor":[35],"(NMDAR)":[36],"plays":[37],"an":[38],"essential":[39],"role":[40],"in":[41,65,72],"synaptic":[42],"plasticity":[43],"[3,4].":[48],"Not":[49],"surprisingly,":[50],"well":[53],"established":[54],"that":[55,92],"NMDAR":[57,120],"major":[60],"target":[61],"of":[62,106,117,119,129],"(ethanol)":[64],"brain":[67],"has":[69],"been":[70],"implicated":[71],"ethanol-associated":[73],"phenotypes":[74],"such":[75],"as":[76,122],"tolerance,":[77],"dependence,":[78],"withdrawal,":[79],"craving,":[80],"relapse":[82],"[5,6].":[83],"This":[84],"chapter":[85],"focuses":[86],"on":[87,96],"studies":[88],"elucidating":[89],"molecular":[90],"mechanisms":[91],"underlie":[93],"ethanol\u2019s":[94,107],"actions":[95],"NMDAR,":[98],"discusses":[100],"physiological":[102],"behavioral":[104],"consequences":[105],"actions.":[108],"Finally,":[109],"we":[110],"summarize":[111],"information":[112],"regarding":[113],"potential":[115],"modulators":[118],"function":[121],"medication":[123],"treat":[125],"adverse":[127],"effects":[128],"alcoholism.":[130]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}