{"id":"https://openalex.org/W782176458","doi":null,"title":"Identification of the Rassf3 gene as a potential tumor suppressor responsible for the resistance to mammary tumor development in MMTV/neu transgenic mice","display_name":"Identification of the Rassf3 gene as a potential tumor suppressor responsible for the resistance to mammary tumor development in MMTV/neu transgenic mice","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W782176458","mag":"782176458"},"language":"en","primary_location":{"id":"pmh:oai:open.clemson.edu:all_dissertations-1026","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/26","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025021693","display_name":"Isabelle Jacquemart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Isabelle Jacquemart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025021693"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.47119998931884766,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.21719999611377716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ras-effectors","display_name":"Ras effectors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mmtv-neu-transgenic-mice","display_name":"MMTV-neu transgenic mice","score":0.9449999928474426},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.7570000290870667},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.675000011920929},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.7369999885559082},{"id":"https://openalex.org/keywords/h-ras","display_name":"H-Ras","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6730021238327026},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.6582167148590088},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6422470808029175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6390213966369629},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.62310791015625},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6145612001419067},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6058498024940491},{"id":"https://openalex.org/C2779777497","wikidata":"https://www.wikidata.org/wiki/Q1775519","display_name":"Mouse mammary tumor virus","level":3,"score":0.5707958936691284},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.565864622592926},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5255179405212402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45801371335983276},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3788986802101135},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3493478298187256},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.1604035198688507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14909106492996216}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:open.clemson.edu:all_dissertations-1026","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/26","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1026","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/cgi/viewcontent.cgi?article=1026&context=all_dissertations","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"mag:782176458","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/26/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":242,"referenced_works":["https://openalex.org/W15275643","https://openalex.org/W53330856","https://openalex.org/W73211306","https://openalex.org/W135858620","https://openalex.org/W150702863","https://openalex.org/W161274711","https://openalex.org/W167124021","https://openalex.org/W238668910","https://openalex.org/W323078090","https://openalex.org/W1491459594","https://openalex.org/W1503659850","https://openalex.org/W1514463309","https://openalex.org/W1531555307","https://openalex.org/W1535066808","https://openalex.org/W1550594329","https://openalex.org/W1562589309","https://openalex.org/W1567375762","https://openalex.org/W1570686199","https://openalex.org/W1577974112","https://openalex.org/W1598690774","https://openalex.org/W1601076886","https://openalex.org/W1601571585","https://openalex.org/W1601977847","https://openalex.org/W1606635237","https://openalex.org/W1757788795","https://openalex.org/W1763011611","https://openalex.org/W1771410149","https://openalex.org/W1775510084","https://openalex.org/W1804903119","https://openalex.org/W1813571362","https://openalex.org/W1824627541","https://openalex.org/W1874881634","https://openalex.org/W1876993848","https://openalex.org/W1890809256","https://openalex.org/W1953337176","https://openalex.org/W1963796006","https://openalex.org/W1964991793","https://openalex.org/W1966683022","https://openalex.org/W1966823692","https://openalex.org/W1967647822","https://openalex.org/W1968075576","https://openalex.org/W1968283357","https://openalex.org/W1968910405","https://openalex.org/W1971541597","https://openalex.org/W1971915715","https://openalex.org/W1972004339","https://openalex.org/W1973046279","https://openalex.org/W1973554661","https://openalex.org/W1976630549","https://openalex.org/W1976764293","https://openalex.org/W1976918496","https://openalex.org/W1981116197","https://openalex.org/W1982093899","https://openalex.org/W1987597886","https://openalex.org/W1988409513","https://openalex.org/W1988603352","https://openalex.org/W1989510858","https://openalex.org/W1990133575","https://openalex.org/W1990367849","https://openalex.org/W1990578004","https://openalex.org/W1991494214","https://openalex.org/W1995216176","https://openalex.org/W1996946800","https://openalex.org/W1997141458","https://openalex.org/W1998120891","https://openalex.org/W2001177765","https://openalex.org/W2001627828","https://openalex.org/W2002032779","https://openalex.org/W2002302708","https://openalex.org/W2003365291","https://openalex.org/W2003460319","https://openalex.org/W2006174096","https://openalex.org/W2007510308","https://openalex.org/W2007537308","https://openalex.org/W2007916146","https://openalex.org/W2009031388","https://openalex.org/W2010487043","https://openalex.org/W2011912935","https://openalex.org/W2013683656","https://openalex.org/W2022792151","https://openalex.org/W2022896763","https://openalex.org/W2023271196","https://openalex.org/W2028740022","https://openalex.org/W2029169609","https://openalex.org/W2030976397","https://openalex.org/W2033693803","https://openalex.org/W2033755897","https://openalex.org/W2034059681","https://openalex.org/W2034269086","https://openalex.org/W2035073888","https://openalex.org/W2035344810","https://openalex.org/W2035768468","https://openalex.org/W2036243096","https://openalex.org/W2036581624","https://openalex.org/W2037297522","https://openalex.org/W2037755687","https://openalex.org/W2038631211","https://openalex.org/W2039633811","https://openalex.org/W2044218149","https://openalex.org/W2045553710","https://openalex.org/W2046379373","https://openalex.org/W2046990478","https://openalex.org/W2048295632","https://openalex.org/W2049186397","https://openalex.org/W2052051648","https://openalex.org/W2052333525","https://openalex.org/W2054740212","https://openalex.org/W2055840758","https://openalex.org/W2055973720","https://openalex.org/W2056750804","https://openalex.org/W2057755903","https://openalex.org/W2058184498","https://openalex.org/W2063367127","https://openalex.org/W2064372625","https://openalex.org/W2064478922","https://openalex.org/W2066118482","https://openalex.org/W2066638490","https://openalex.org/W2066885441","https://openalex.org/W2067376187","https://openalex.org/W2068124694","https://openalex.org/W2068830359","https://openalex.org/W2070033201","https://openalex.org/W2070393186","https://openalex.org/W2070985209","https://openalex.org/W2072451938","https://openalex.org/W2072481802","https://openalex.org/W2072890735","https://openalex.org/W2072928113","https://openalex.org/W2073038957","https://openalex.org/W2074180520","https://openalex.org/W2074332692","https://openalex.org/W2075082022","https://openalex.org/W2078457029","https://openalex.org/W2079382430","https://openalex.org/W2079816467","https://openalex.org/W2083522244","https://openalex.org/W2085307337","https://openalex.org/W2085848981","https://openalex.org/W2086619383","https://openalex.org/W2087457210","https://openalex.org/W2088428799","https://openalex.org/W2088732158","https://openalex.org/W2088740611","https://openalex.org/W2088939240","https://openalex.org/W2088985926","https://openalex.org/W2089229971","https://openalex.org/W2090001706","https://openalex.org/W2090429649","https://openalex.org/W2092612993","https://openalex.org/W2093965961","https://openalex.org/W2094616662","https://openalex.org/W2094632474","https://openalex.org/W2095156669","https://openalex.org/W2095483608","https://openalex.org/W2096530483","https://openalex.org/W2098294628","https://openalex.org/W2098953839","https://openalex.org/W2099528517","https://openalex.org/W2099536948","https://openalex.org/W2101824868","https://openalex.org/W2102085111","https://openalex.org/W2103986437","https://openalex.org/W2108795463","https://openalex.org/W2111202034","https://openalex.org/W2111909938","https://openalex.org/W2112262032","https://openalex.org/W2112533411","https://openalex.org/W2113459016","https://openalex.org/W2113635885","https://openalex.org/W2115516953","https://openalex.org/W2116602941","https://openalex.org/W2116721679","https://openalex.org/W2117237148","https://openalex.org/W2118908721","https://openalex.org/W2120755323","https://openalex.org/W2122048408","https://openalex.org/W2123139458","https://openalex.org/W2123206362","https://openalex.org/W2123303833","https://openalex.org/W2129318515","https://openalex.org/W2129580332","https://openalex.org/W2130155089","https://openalex.org/W2131994307","https://openalex.org/W2133108603","https://openalex.org/W2135598172","https://openalex.org/W2136222819","https://openalex.org/W2136982991","https://openalex.org/W2139716410","https://openalex.org/W2140084692","https://openalex.org/W2140512869","https://openalex.org/W2141393790","https://openalex.org/W2143536404","https://openalex.org/W2144535642","https://openalex.org/W2144898489","https://openalex.org/W2145950214","https://openalex.org/W2146324932","https://openalex.org/W2149219789","https://openalex.org/W2150091603","https://openalex.org/W2152401699","https://openalex.org/W2153645840","https://openalex.org/W2156980924","https://openalex.org/W2158150128","https://openalex.org/W2159015696","https://openalex.org/W2159490482","https://openalex.org/W2159594827","https://openalex.org/W2163032998","https://openalex.org/W2163406329","https://openalex.org/W2163945308","https://openalex.org/W2165023373","https://openalex.org/W2165337069","https://openalex.org/W2165537599","https://openalex.org/W2165639753","https://openalex.org/W2168770561","https://openalex.org/W2169052759","https://openalex.org/W2171584014","https://openalex.org/W2171685800","https://openalex.org/W2182115835","https://openalex.org/W2185924837","https://openalex.org/W2186136307","https://openalex.org/W2261427161","https://openalex.org/W2273735948","https://openalex.org/W2301036151","https://openalex.org/W2312296163","https://openalex.org/W2315580985","https://openalex.org/W2316469384","https://openalex.org/W2317971350","https://openalex.org/W2318605753","https://openalex.org/W2323068097","https://openalex.org/W2324618404","https://openalex.org/W2324890938","https://openalex.org/W2328470294","https://openalex.org/W2331676402","https://openalex.org/W2333460185","https://openalex.org/W2400130046","https://openalex.org/W2409635342","https://openalex.org/W2415035660","https://openalex.org/W2416545774","https://openalex.org/W2418123936","https://openalex.org/W2418402999","https://openalex.org/W2432729770","https://openalex.org/W2530014580","https://openalex.org/W2966588861"],"related_works":["https://openalex.org/W2159377389","https://openalex.org/W1976599628","https://openalex.org/W2265096984","https://openalex.org/W1499565330","https://openalex.org/W1480809785","https://openalex.org/W1483414363","https://openalex.org/W93825644","https://openalex.org/W1529081594","https://openalex.org/W1990293928","https://openalex.org/W2067651221"],"abstract_inverted_index":{"The":[0,185,205,267],"MMTV/neu":[1,29,60,129,135,306],"transgenic":[2,62,136,307],"mouse":[3,154,200,253],"line":[4],"is":[5,120,149,292],"a":[6,20,95,174,289,293],"well-documented":[7],"animal":[8],"model":[9],"for":[10,54],"studying":[11],"HER2/neu-related":[12],"breast":[13,201,232],"cancer.":[14],"It":[15],"has":[16],"been":[17],"reported":[18],"that":[19,51,116,145,188,240,287,296],"small":[21],"percentage,":[22],"approximately":[23],"20%,":[24],"of":[25,36,43,97,126,167,176,190,208,215,220],"the":[26,34,41,44,49,55,71,77,84,117,123,127,146,165,168,221,225,299],"virgin":[27,272,304],"female":[28,61,273,305],"mice":[30,130,275],"seems":[31,210],"resistant":[32],"to":[33,69,94,132,158,211,279],"development":[35],"mammary":[37,78,124,155,172,262,268,300],"gland":[38,125],"adenoma,":[39],"despite":[40],"overexpression":[42,189],"neu":[45,259],"oncogene.":[46],"To":[47,162],"identify":[48],"factors":[50],"are":[52],"responsible":[53],"tumor":[56,101,269,301],"resistance":[57],"in":[58,73,76,106,111,122,152,171,177,180,195,229,261,271,303],"these":[59,284],"mice,":[63,142],"comparative":[64],"genetic":[65],"profiling":[66],"was":[67,104,264,276],"used":[68],"screen":[70],"alterations":[72],"gene":[74,82,119,148,170,223,228,295],"expression":[75],"gland.":[79],"A":[80,249],"novel":[81,250],"named":[83],"RAS":[85,98,290],"Association":[86],"domain":[87],"(RalGDS/AF-6)":[88],"Family":[89],"3":[90],"(Rassf3),":[91],"which":[92],"belongs":[93],"family":[96],"effectors":[99],"and":[100,143,179,199,258],"suppressor":[102],"genes":[103,260],"identified":[105],"this":[107,112],"study.":[108],"Data":[109],"presented":[110],"dissertation":[113],"show:":[114],"1)":[115],"Rassf3":[118,147,169,222,257],"overexpressed":[121],"tumor-resistant":[128],"compared":[131,157,278],"their":[133,280],"tumor-susceptible":[134],"littermates":[137],"or":[138],"age-matched":[139],"non-transgenic":[140],"FVB":[141],"2)":[144],"significantly":[150],"up-regulated":[151],"neu-specific":[153],"tumors":[156],"adjacent":[159],"normal":[160],"tissues.":[161],"further":[163],"confirm":[164],"role":[166],"carcinogenesis,":[173],"series":[175],"vitro":[178],"vivo":[181],"experiments":[182],"were":[183],"explored.":[184],"results":[186],"show":[187],"RASSF3":[191,209,241],"inhibits":[192],"cell":[193,203],"proliferation":[194],"HER2":[196],"positive":[197],"human":[198,231],"cancer":[202,233],"lines.":[204],"inhibitory":[206],"effect":[207],"be":[212],"through":[213],"induction":[214],"apoptosis.":[216],"In":[217],"addition,":[218],"co-transfection":[219],"with":[224,246],"activated":[226],"H-RAS":[227,236,247],"SKBR3":[230],"cells":[234],"decreased":[235],"protein":[237,242],"level,":[238],"suggesting":[239],"can":[243],"indirectly":[244],"interact":[245],"protein.":[248],"MMTV/Rassf3-neu":[251],"bi-transgenic":[252,274],"line,":[254],"overexpressing":[255],"both":[256],"glands,":[263],"also":[265],"established.":[266],"incidence":[270,302],"delayed":[277],"MMTV/neu+/-":[281],"littermates.":[282],"Together,":[283],"data":[285],"suggest":[286],"Rassf3,":[288],"effector,":[291],"candidate":[294],"may":[297],"influence":[298],"mice.":[308]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}