{"id":"https://openalex.org/W7820156","doi":null,"title":"Oligoclonal immunoglobulin bands in serum in association with chronic viral hepatitis.","display_name":"Oligoclonal immunoglobulin bands in serum in association with chronic viral hepatitis.","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W7820156","mag":"7820156","pmid":"https://pubmed.ncbi.nlm.nih.gov/2375310"},"language":"en","primary_location":{"id":"pmid:2375310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2375310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111665577","display_name":"Epaminondas V. Tsianos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E V Tsianos","raw_affiliation_strings":["Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022731052","display_name":"Adrian M. Di Bisceglie","orcid":"https://orcid.org/0000-0002-6075-9305","observed_orcids":["https://orcid.org/0000-0002-6075-9305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Di Bisceglie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031444119","display_name":"Nick M. Papadopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N M Papadopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Costello","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Costello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111528427","display_name":"Jay H. Hoofnagle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Hoofnagle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3726,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.60123267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"85","issue":"8","first_page":"1005","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-viral-hepatitis","display_name":"chronic viral hepatitis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/serum-immunoglobulins","display_name":"serum immunoglobulins","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hypergammaglobulinemia","display_name":"hypergammaglobulinemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hbeag","display_name":"HBeAg","score":0.7710000276565552},{"id":"https://openalex.org/keywords/disease-activity-markers","display_name":"disease activity markers","score":0.6660000085830688},{"id":"https://openalex.org/keywords/protein-electrophoresis","display_name":"protein electrophoresis","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7851496934890747},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6705977320671082},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5876412987709045},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.5729740858078003},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5690258741378784},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5575893521308899},{"id":"https://openalex.org/C79162176","wikidata":"https://www.wikidata.org/wiki/Q5520338","display_name":"Gamma globulin","level":3,"score":0.5089559555053711},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.5031432509422302}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001797","descriptor_name":"Blood Protein Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006513","descriptor_name":"Hepatitis B e Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006525","descriptor_name":"Hepatitis, Viral, Human","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006525","descriptor_name":"Hepatitis, Viral, Human","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2375310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2375310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:7820156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2375310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","score":0.5799999833106995,"display_name":"Reduced inequalities"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2008937149","https://openalex.org/W2061662057","https://openalex.org/W2348762241","https://openalex.org/W2052496406","https://openalex.org/W41190495","https://openalex.org/W204602122","https://openalex.org/W2313478022","https://openalex.org/W2088738784","https://openalex.org/W4384822985","https://openalex.org/W2403237690"],"abstract_inverted_index":{"We":[0],"studied":[1],"serum":[2,77,93,127,198],"immunoglobulins":[3],"in":[4,44,55,80,131,143,147,171,197,214],"54":[5],"patients":[6,81],"with":[7,15,82,114,168],"chronic":[8,211],"viral":[9,212],"hepatitis.":[10,124],"The":[11,89],"majority":[12],"had":[13],"hyperglobulinemia,":[14],"immunoglobulin":[16,42,87,94,108,150,195],"G":[17,95],"(IgG)":[18],"being":[19],"elevated":[20],"the":[21,28,34,38,62,104,115,191,206],"most.":[22],"High":[23],"resolution":[24],"protein":[25],"electrophoresis":[26],"revealed":[27],"presence":[29,105],"of":[30,37,64,72,103,106,117,123,176,180,193,210],"oligoclonal":[31,86,107,149,194],"bands":[32,52,151,196],"within":[33],"gamma-globulin":[35],"region":[36],"electrophoretic":[39],"pattern":[40],"(oligoclonal":[41],"bands)":[43],"32":[45],"(59%)":[46],"patients.":[47,216],"Between":[48],"two":[49],"and":[50,76,83,92,158,208],"seven":[51],"were":[53,97,129],"noted":[54,142],"each":[56],"sample.":[57],"In":[58],"order":[59],"to":[60,99,136,204],"analyze":[61],"significance":[63],"this":[65],"observation,":[66],"we":[67],"performed":[68],"stepwise":[69],"discriminant":[70],"analysis":[71],"clinical,":[73],"demographic,":[74],"serological,":[75],"biochemical":[78],"features":[79],"without":[84],"detectable":[85],"bands.":[88,109],"patient's":[90],"ages":[91],"levels":[96],"found":[98,113],"be":[100,200],"important":[101],"predictors":[102],"No":[110],"correlation":[111],"was":[112,141,166],"type":[116],"hepatitis,":[118],"disease":[119],"severity,":[120],"or":[121],"duration":[122],"On":[125],"follow-up,":[126],"samples":[128],"retested":[130],"20":[132],"patients,":[133],"over":[134,161],"5":[135],"60":[137],"months.":[138],"Significant":[139],"change":[140],"only":[144],"one":[145],"patient":[146],"whom":[148],"(initially":[152],"very":[153],"prominent)":[154],"became":[155],"progressively":[156],"weaker":[157],"finally":[159],"disappeared":[160],"a":[162,201],"5-yr":[163],"period.":[164],"This":[165],"associated":[167],"an":[169],"improvement":[170],"his":[172],"hepatitis":[173,177,181,213],"after":[174],"loss":[175,179],"following":[178],"B":[182],"e":[183],"antigen":[184],"from":[185],"serum.":[186],"These":[187],"observations":[188],"suggest":[189],"that":[190],"determination":[192],"may":[199],"useful":[202],"marker":[203],"study":[205],"course":[207],"activity":[209],"selected":[215]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}