{"id":"https://openalex.org/W77885983","doi":null,"title":"D\u00e9veloppement de m\u00e9thodes pour la quantification des particules pseudo-virales d\u2019influenza","display_name":"D\u00e9veloppement de m\u00e9thodes pour la quantification des particules pseudo-virales d\u2019influenza","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W77885983","mag":"77885983"},"language":"fr","primary_location":{"id":"pmh:oai:publications.polymtl.ca:788","doi":null,"is_oa":true,"landing_page_url":"https://publications.polymtl.ca/788/","pdf_url":"https://publications.polymtl.ca/788/1/2012_AlexandreLennaertz.pdf","source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lennaertz, A. (2012). D\u00e9veloppement de m\u00e9thodes pour la quantification des particules pseudo-virales d'influenza [Master's thesis, \u00c9cole Polytechnique de Montr\u00e9al].","raw_type":"m\u00e9moire de ma\u00eetrise"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://publications.polymtl.ca/788/1/2012_AlexandreLennaertz.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083707878","display_name":"Alexandre Lennaertz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexandre Lennaertz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083707878"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.8339999914169312},{"id":"https://openalex.org/keywords/virus-like-particles","display_name":"virus-like particles","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.7409999966621399},{"id":"https://openalex.org/keywords/neuraminidase","display_name":"neuraminidase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/influenza-vaccine-production","display_name":"influenza vaccine production","score":0.4129999876022339},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.5649999976158142},{"id":"https://openalex.org/keywords/vero-cells","display_name":"Vero cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pandemic-influenza-preparedness","display_name":"pandemic influenza preparedness","score":0.5080000162124634},{"id":"https://openalex.org/keywords/vaccine-supply-chain","display_name":"vaccine supply chain","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.38551563024520874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2939550280570984}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:publications.polymtl.ca:788","doi":null,"is_oa":true,"landing_page_url":"https://publications.polymtl.ca/788/","pdf_url":"https://publications.polymtl.ca/788/1/2012_AlexandreLennaertz.pdf","source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lennaertz, A. (2012). D\u00e9veloppement de m\u00e9thodes pour la quantification des particules pseudo-virales d'influenza [Master's thesis, \u00c9cole Polytechnique de Montr\u00e9al].","raw_type":"m\u00e9moire de ma\u00eetrise"},{"id":"mag:77885983","doi":null,"is_oa":false,"landing_page_url":"https://publications.polymtl.ca/788/1/2012_AlexandreLennaertz.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:publications.polymtl.ca:788","doi":null,"is_oa":true,"landing_page_url":"https://publications.polymtl.ca/788/","pdf_url":"https://publications.polymtl.ca/788/1/2012_AlexandreLennaertz.pdf","source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lennaertz, A. (2012). D\u00e9veloppement de m\u00e9thodes pour la quantification des particules pseudo-virales d'influenza [Master's thesis, \u00c9cole Polytechnique de Montr\u00e9al].","raw_type":"m\u00e9moire de ma\u00eetrise"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W77885983.pdf","grobid_xml":"https://content.openalex.org/works/W77885983.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W39483676","https://openalex.org/W75152324","https://openalex.org/W177909858","https://openalex.org/W935156426","https://openalex.org/W1498554739","https://openalex.org/W1525947002","https://openalex.org/W1716807906","https://openalex.org/W1924246380","https://openalex.org/W1963718186","https://openalex.org/W1965813627","https://openalex.org/W1967090622","https://openalex.org/W1968314354","https://openalex.org/W1968801913","https://openalex.org/W1974067011","https://openalex.org/W1975162921","https://openalex.org/W1976861769","https://openalex.org/W1978677400","https://openalex.org/W1981531030","https://openalex.org/W1984855202","https://openalex.org/W1985563292","https://openalex.org/W1990151313","https://openalex.org/W1990748664","https://openalex.org/W1991581979","https://openalex.org/W1996822570","https://openalex.org/W1997341424","https://openalex.org/W1999919523","https://openalex.org/W2002374989","https://openalex.org/W2004313038","https://openalex.org/W2010821699","https://openalex.org/W2011735016","https://openalex.org/W2012695091","https://openalex.org/W2013574284","https://openalex.org/W2017076506","https://openalex.org/W2018935345","https://openalex.org/W2024313766","https://openalex.org/W2024557230","https://openalex.org/W2028223954","https://openalex.org/W2029793786","https://openalex.org/W2030883039","https://openalex.org/W2033422865","https://openalex.org/W2035153513","https://openalex.org/W2037859752","https://openalex.org/W2041227040","https://openalex.org/W2041274197","https://openalex.org/W2041753380","https://openalex.org/W2041878614","https://openalex.org/W2050922241","https://openalex.org/W2051367804","https://openalex.org/W2053575849","https://openalex.org/W2054209117","https://openalex.org/W2055515273","https://openalex.org/W2056408484","https://openalex.org/W2058944751","https://openalex.org/W2059608521","https://openalex.org/W2060008923","https://openalex.org/W2062740562","https://openalex.org/W2066355111","https://openalex.org/W2069016094","https://openalex.org/W2069668598","https://openalex.org/W2070706666","https://openalex.org/W2070765070","https://openalex.org/W2070785963","https://openalex.org/W2071068021","https://openalex.org/W2071572891","https://openalex.org/W2073521270","https://openalex.org/W2073870652","https://openalex.org/W2075212292","https://openalex.org/W2075527878","https://openalex.org/W2076175178","https://openalex.org/W2077332396","https://openalex.org/W2078142696","https://openalex.org/W2082413189","https://openalex.org/W2082689737","https://openalex.org/W2084480062","https://openalex.org/W2084526855","https://openalex.org/W2087943888","https://openalex.org/W2088371451","https://openalex.org/W2089783763","https://openalex.org/W2096565446","https://openalex.org/W2098659222","https://openalex.org/W2101994908","https://openalex.org/W2108687311","https://openalex.org/W2108751995","https://openalex.org/W2110527320","https://openalex.org/W2112437424","https://openalex.org/W2121171777","https://openalex.org/W2124159817","https://openalex.org/W2125761044","https://openalex.org/W2135426762","https://openalex.org/W2138064535","https://openalex.org/W2143001591","https://openalex.org/W2149497952","https://openalex.org/W2149850870","https://openalex.org/W2152466788","https://openalex.org/W2152619526","https://openalex.org/W2152912310","https://openalex.org/W2156472928","https://openalex.org/W2157380583","https://openalex.org/W2160576748","https://openalex.org/W2162101630","https://openalex.org/W2163503954","https://openalex.org/W2166530618","https://openalex.org/W2168020376","https://openalex.org/W2168274941","https://openalex.org/W2187177989","https://openalex.org/W2254113059","https://openalex.org/W2339080478","https://openalex.org/W2402551067"],"related_works":["https://openalex.org/W6996096094","https://openalex.org/W7064183943","https://openalex.org/W4392770891","https://openalex.org/W2600714647","https://openalex.org/W2468455946","https://openalex.org/W7056743080","https://openalex.org/W7051762756","https://openalex.org/W2603119681","https://openalex.org/W4391630171","https://openalex.org/W4394843494"],"abstract_inverted_index":{"Le":[0],"virus":[1,63,105,709,936],"de":[2,7,15,34,69,74,99,104,131,135,143,158,185,196,202,208,238,242,253,264,287,292,297,306,316,328,341,344,366,371,380,398,403,413,416,420,424,439,449,464,486,499,507,510,515,522,537,541,549,559,569,578,582,591,606,621,627,641,646,653,669,675,683,687,702,711,741,753,765],"la":[3,35,55,59,77,159,168,173,180,203,217,283,290,358,407,497,508,616,644,692,712,733],"grippe":[4],"est":[5,38,65,116,145,318],"connu":[6],"par":[8,475,502,612,666,707],"le":[9,62,91,259,337,347,418,601,613,629,718],"monde":[10],"pour":[11,57,190,331,357,369,738],"les":[12,27,29,81,86,149,221,225,270,444,453,466,503,525,535,553,557,565,589,651],"nombreux":[13],"problemes":[14],"sante":[16],"publique":[17],"qu\u2019il":[18],"cause":[19,782],"annuellement":[20],"(nombreux":[21],"malades":[22],"voire":[23],"meme":[24,615,650],"morts":[25],"dans":[26,76,200,220,258,299,452,534,556,600,697],"cas":[28,134],"plus":[30,87,395],"invasifs).":[31],"L\u2019Organisation":[32],"Mondiale":[33],"Sante":[36],"(OMS)":[37],"perpetuellement":[39],"en":[40,117,133,230,268,401,469,634,677,694],"alerte":[41],"afin":[42,68,640],"d\u2019etre":[43],"prete":[44],"a":[45,47,83,95,172,178,240,247,273,295,310,431,461,484,492,496,546,637,649,672,728,806,872,970,1109,1311,1395],"repondre":[46],"toute":[48],"nouvelle":[49,236,422],"epidemie":[50],"virulente":[51],"du":[52,164,275,389,527],"virus.":[53,211,1368],"C\u2019est":[54],"raison":[56],"laquelle":[58,179],"vaccination":[60,813],"contre":[61,216],"influenza":[64,710,768,815,1026,1139,1367],"fortement":[66],"conseillee":[67],"contrer":[70],"au":[71,120,129,409],"mieux":[72],"l\u2019etendue":[73],"l\u2019infection":[75],"population,":[78,826],"incluant":[79,394],"principalement":[80,594],"personnes":[82],"risque.\nLes":[84],"vaccins":[85,215,293,426],"couramment":[88],"retrouves":[89],"sur":[90,350,657,662],"marche":[92],"sont":[93,102,228,262,385],"produits":[94,219],"partir":[96],"d\u2019oeufs":[97],"embryonnes":[98],"poulet":[100],"et":[101,162,282,312,343,406,448,457,478,555,568,610,685,690,748],"composes":[103],"sous":[106],"forme":[107],"inactivee":[108],"ou":[109,224,354,368],"encore":[110],"attenuee.":[111],"Considerant":[112],"qu\u2019une":[113],"dose":[114,881],"vaccinale":[115],"moyenne":[118],"obtenue":[119],"depart":[121],"d\u2019un":[122,170,745],"oeuf,":[123],"cela":[124],"pose":[125],"des":[126,187,194,210,320,339,351,360,392,429,462,529,563,571,604,618,623,658,663,698,723,750,755],"contraintes":[127],"severes":[128],"niveau":[130],"l\u2019approvisionnement":[132],"pandemies":[136],"durant":[137],"lesquelles":[138],"un":[139,300,303,435,708],"nombre":[140,305],"tres":[141,608],"eleve":[142],"doses":[144,664],"requis.":[146],"De":[147],"plus,":[148],"longs":[150],"delais":[151],"d\u2019approvisionnement":[152],"(6":[153],"mois":[154],"environ":[155],"entre":[156,552],"l\u2019isolement":[157],"souche":[160,713],"virale":[161],"l\u2019obtention":[163],"vaccin)":[165],"ainsi":[166],"que":[167,279,588,732],"possibilite":[169],"retour":[171],"virulence":[174,911],"soulevent":[175],"certaines":[176],"problematiques":[177],"communaute":[181],"scientifique":[182],"tente":[183],"toujours":[184,324],"repondre.\nUne":[186],"alternatives":[188],"proposees":[189],"pallier":[191],"aux":[192,625],"lacunes":[193],"modes":[195],"production":[197,209,291,342,400,428,509,538,607,622,754,859,937,948,1028,1059,1117,1143,1233,1292,1297,1306,1405],"traditionnels":[198],"reside":[199],"l\u2019utilisation":[201],"culture":[204,402,701,929,1121,1254,1327],"cellulaire":[205,545],"comme":[206,374,761],"plateforme":[207],"Ainsi,":[212],"plusieurs":[213,532],"candidats":[214,425],"grippe,":[218],"cellules":[222,226,404,454,470,542,703],"CHO":[223,958],"VERO,":[227],"actuellement":[229],"cours":[231],"d\u2019essais":[232,720],"cliniques.":[233],"Recemment,":[234],"une":[235,488,679,763],"generation":[237,423,972,1138],"vaccins,":[239],"base":[241,296],"particules":[243,255,467],"pseudo-virales":[244,256],"(ou":[245],"VLP),":[246],"ete":[248,432,473,638,673,730],"developpee.":[249],"Les":[250],"principaux":[251],"avantages":[252],"ces":[254,332,511,583],"resident":[257],"fait":[260,614],"qu\u2019elles":[261],"denuees":[263],"genome":[265,317,1036],"viral,":[266],"tout":[267],"comportant":[269],"antigenes":[271],"necessaires":[272],"l\u2019activation":[274],"systeme":[276,436],"immunitaire,":[277],"tels":[278],"l\u2019hemagglutinine":[280],"(HA)":[281,1000],"neuraminidase":[284,1002],"(NA).\nCependant,":[285],"avant":[286],"pouvoir":[288],"transposer":[289],"d\u2019influenza":[294],"VLP":[298,430,500,526,572,1105,1142,1201,1208,1225,1296,1404],"contexte":[301],"industriel,":[302],"certain":[304],"points":[307,1016],"critiques":[308],"restent":[309],"developper":[311],"optimiser.":[313],"Notamment,":[314],"l\u2019absence":[315],"l\u2019un":[319],"facteurs":[321],"qui":[322],"limite":[323],"l\u2019etablissement":[325],"d\u2019une":[326,411,631,700],"methode":[327,412,632,764],"quantification":[329,359,365,414,645,1050],"efficace":[330],"particules.":[333],"Ceci":[334],"freine":[335],"considerablement":[336],"developpement":[338,419,630],"etapes":[340,463],"purification,":[345,465,1179],"dont":[346],"suivi":[348],"repose":[349],"methodes\nv\nanalytiques":[352],"indirectes":[353],"imprecises":[355],"developpees":[356],"proteines":[361,372,445],"totales":[362],"(SDS-PAGE,":[363,1081],"Western-Blot,":[364,1082],"proteines)":[367],"celle":[370,595],"specifiques":[373],"HA":[375,647,695,1092,1094,1322,1353,1383],"(SRID,":[376,1093],"test":[377],"HA).\nLes":[378],"objectifs":[379],"cette":[381,421,757],"maitrise":[382],"recherche":[383],"se":[384,759],"donc":[386],"articules":[387],"autour":[388],"procede":[390],"general":[391],"VLP,":[393,756],"specifiquement":[396],"l\u2019etude":[397],"leur":[399],"d\u2019insectes":[405,455],"mise":[408],"point":[410],"permettant":[415,682],"soutenir":[417],"d\u2019influenza.\nLa":[427],"analysee":[433],"avec":[434,722],"d\u2019expression":[437,567],"compose":[438],"baculovirus":[440,504,592,1205,1277],"recombinants":[441],"(rBV)":[442,1154],"exprimant":[443],"HA,":[446,597,1157],"NA":[447],"matrice":[450],"M1":[451,1160],"Sf9":[456,471,1164,1174],"High":[458,1166],"Five.":[459],"Suite":[460],"generees":[468],"ont":[472],"analysees":[474],"SDS-PAGE,":[476,1181],"Western-Blot":[477,1182],"microscopie":[479],"electronique.":[480],"Cette":[481],"derniere":[482],"analyse":[483],"permis":[485,521],"detecter":[487,684],"contamination":[489,1192],"importante":[490],"(100":[491],"1000":[493,1196],"fois":[494],"superieure":[495],"quantite":[498],"presentes)":[501],"utilises":[505],"lors":[506],"VLP.":[512,1271],"Une":[513],"etape":[514],"purification":[516,560,1061,1214,1251],"supplementaire":[517],"n\u2019a":[518],"cependant":[519],"pas":[520,574],"separer":[523],"efficacement":[524],"reste":[528],"contaminants.":[530],"Malgre":[531],"modifications":[533],"parametres":[536,558],"(e.g.":[539,561,1234,1253],"choix":[540,548],"hotes,":[543],"concentration":[544,693,1239],"infection,":[547,1241],"MOI,":[550,1244],"rapports":[551],"BV)":[554],"traitement":[562],"cultures),":[564],"niveaux":[566],"purete":[570],"n\u2019ont":[573],"pu":[575],"etre":[576,736],"augmentes":[577],"maniere":[579],"significative.":[580],"Lors":[581],"essais,":[584],"il":[585,671,727],"s\u2019est":[586],"avere":[587],"constructions":[590,1278],"disponibles,":[593],"contenant":[596],"etaient":[598],"instables":[599],"temps,":[602],"entrainant":[603],"rendements":[605],"faibles":[609],"limitant":[611],"poursuite":[617],"travaux":[619,659],"d\u2019optimisation":[620],"VLP.\nParallelement":[624],"tests":[626],"production,":[628],"HPLC":[633,1313],"phase":[635],"inversee":[636],"entrepris":[639],"permettre":[642],"notamment":[643],"directement":[648],"surnageants":[652],"culture.":[654],"En":[655],"s\u2019appuyant":[656],"preliminaires":[660],"realises":[661],"vaccinales":[665],"d\u2019autres":[667],"groupes":[668],"recherche,":[670],"possible":[674,803],"mettre":[676],"place":[678],"procedure":[680],"adequate":[681],"quantifier":[686],"facon":[688],"rapide":[689,747],"precise":[691],"presente":[696],"echantillons":[699],"HEK":[704,1357],"293":[705,1358],"infectees":[706],"A/Puerto":[714,1364],"Rico/8/34":[715,1365],"(H1N1).":[716],"Par":[717],"biais":[719],"conduits":[721],"souches":[724],"virales":[725],"distinctes,":[726],"egalement":[729],"demontre":[731],"technique":[734,758,1401],"peut":[735],"utilisee":[737],"analyser":[739],"differents\nvi\ntypes":[740],"HA.":[742],"Dans":[743],"l\u2019optique":[744],"criblage":[746],"precis":[749],"differentes":[751],"strategies":[752],"demarque":[760],"etant":[762],"choix.----------Every":[766],"year,":[767],"is":[769,794,816,876,882,891,913,920,1037,1129],"responsible":[770],"for":[771,935,1052,1078,1207,1402],"numerous":[772],"health":[773],"problems":[774],"world-wide":[775],"mainly":[776,993],"due":[777],"to":[778,798,801,818,824,902,923,941,1023,1072,1103,1131,1195,1199,1221,1257,1290,1304,1319,1348,1381],"infections,":[779],"which":[780],"can":[781],"death":[783],"in":[784,847,863,868,957,966,1118,1163,1173,1264,1317,1355],"the":[785,802,820,825,827,840,869,889,897,903,908,917,927,943,946,1011,1041,1045,1056,1067,1104,1113,1116,1123,1133,1156,1200,1204,1224,1227,1232,1247,1250,1265,1276,1281,1295,1305,1308,1321,1326,1352,1356,1363,1376],"most":[786,828],"serious":[787],"cases.":[788],"The":[789,1033,1170,1186],"World":[790],"Health":[791],"Organization":[792],"(WHO)":[793],"continuously":[795],"on":[796,839,976,994,1112,1335,1343,1371],"alert":[797],"rapidly":[799],"respond":[800],"emergence":[804],"of":[805,865,871,910,926,945,973,1007,1010,1035,1040,1047,1058,1097,1115,1125,1135,1213,1231,1243,1270,1310,1378],"pandemic":[807,873],"viral":[808,845,996,1373,1388],"strain.":[809],"For":[810],"this":[811,858,1098,1136,1379,1391],"reason,":[812],"against":[814,952],"recommended":[817],"prevent":[819],"infection":[821],"from":[822,884,896,1226,1325],"spreading":[823],"concerning":[829],"cases":[830],"being":[831,964],"within":[832],"high":[833],"risk":[834,909],"group":[835],"populations.\nVaccines":[836],"frequently":[837],"found":[838,1347],"market":[841],"are":[842,955,962,1005,1063,1070,1101],"obtained":[843],"by":[844,1180,1203,1339,1362],"replication":[846],"embryonated":[848,886],"chicken":[849],"eggs":[850],"and":[851,907,1001,1004,1021,1060,1074,1122,1159,1165,1183,1249,1267,1331,1350,1398],"contain":[852],"inactivated":[853],"or":[854,959,1086],"attenuated":[855],"viruses.":[856],"However,":[857],"method":[860,1051,1127,1314,1380,1392],"presents":[861],"limitations":[862,944],"terms":[864],"egg":[866],"availability":[867],"case":[870],"as":[874,931,989,1066,1091,1394],"it":[875,1218],"estimated":[877],"that":[878,916,954,1043,1128],"one":[879,885,1039],"vaccine":[880,905,1344],"produced":[883,956,1172],"egg.":[887],"Moreover,":[888],"process":[890,1107],"long":[892],"(about":[893,1193],"6":[894],"months":[895],"first":[898],"strain":[899],"isolation":[900],"step":[901,1212],"final":[904],"formulation)":[906],"reactivation":[912],"another":[914,1211],"drawback":[915],"scientific":[918],"community":[919],"still":[921,1017],"trying":[922],"alleviate.\nThe":[924],"use":[925],"cell":[928,1120,1236,1238,1359],"technology":[930],"an":[932,1030,1048,1148,1190],"expressing":[933,1155],"platform":[934],"has":[938,1144,1215],"been":[939,982,1145,1216],"proposed":[940],"circumvent":[942],"current":[947],"method.":[949],"Vaccine":[950],"candidates":[951],"flu":[953],"VERO":[960],"cells":[961,1175],"currently":[963],"evaluated":[965],"clinical":[967],"trials.":[968],"Recently,":[969],"new":[971,1137],"vaccines,":[974],"based":[975,1334,1370],"Virus":[977],"Like":[978],"Particles":[979],"(VLP)":[980],"have":[981],"developed.":[983],"These":[984],"particles":[985,1171],"present":[986],"some":[987,1014,1087,1284],"advantages":[988],"their":[990],"activity":[991],"relies":[992],"influenza\u2019s":[995],"immunogenic":[997],"activators,":[998],"hemagglutinin":[999],"(NA),":[1003],"exempt":[1006],"genetic":[1008],"material":[1009],"native":[1012],"virus.\nHowever,":[1013],"critical":[1015],"require":[1018],"further":[1019],"development":[1020,1057,1134,1309],"optimization":[1022,1298],"get":[1024],"any":[1025,1262],"VLP-vaccine":[1027],"into":[1029],"industrial":[1031],"environment.":[1032],"lack":[1034],"actually":[1038],"parameters":[1042,1252],"restrain":[1044],"establishment":[1046],"efficient":[1049],"these":[1053,1274],"particles.":[1054],"Consequently,":[1055,1294,1390],"methods":[1062,1076],"considerably":[1064],"hindered":[1065],"analytical":[1068],"techniques":[1069],"limited":[1071],"indirect":[1073],"imprecise":[1075],"developed":[1077],"total":[1079,1083],"proteins":[1080,1089,1162],"protein":[1084,1384],"quantification)":[1085],"specific":[1088,1110],"such":[1090],"assay).\nThe":[1095],"objectives":[1096],"research":[1099,1341],"master":[1100],"related":[1102],"manufacturing":[1106],"with":[1108,1147,1386],"focus":[1111],"study":[1114],"insect":[1119,1168],"set-up":[1124],"a\nviii\nquantification":[1126],"able":[1130],"support":[1132],"sub-unit":[1140],"vaccine.\nInitially,":[1141],"studied":[1146],"expression":[1149,1266],"system":[1150],"including":[1151],"recombinant":[1152],"baculoviruses":[1153],"NA,":[1158],"matrix":[1161],"Five":[1167],"cells.":[1169],"were":[1176],"analyzed,":[1177],"after":[1178],"electron":[1184],"microscopy.":[1185],"latter":[1187],"analysis":[1188],"detected":[1189],"important":[1191],"100":[1194],"times":[1197],"superior":[1198],"contents)":[1202],"used":[1206],"production.":[1209],"Although":[1210],"added,":[1217],"was":[1219,1300,1315,1346],"impossible":[1220],"efficiently":[1222],"separate":[1223],"surrounding":[1228],"contamination.":[1229],"Modifications":[1230],"host":[1235],"system,":[1237],"at":[1240],"choice":[1242],"ratio":[1245],"between":[1246],"baculoviruses)":[1248],"treatments":[1255],"previous":[1256],"harvest)":[1258],"did":[1259],"not":[1260],"give":[1261],"improvement":[1263],"purity":[1268],"levels":[1269],"Furthermore,":[1272],"during":[1273],"trials,":[1275],"available,":[1279],"especially":[1280],"rBV-HA,":[1282],"showed":[1283],"infectious":[1285],"instability":[1286],"over":[1287],"time,":[1288],"leading":[1289],"low":[1291],"yields.":[1293],"workplan":[1299],"significantly":[1301],"delayed.\nIn":[1302],"addition":[1303],"experiments,":[1307],"reversed-phase":[1312],"investigated":[1316],"order":[1318],"quantify":[1320,1351],"concentrations":[1323,1354],"directly":[1324],"supernatant.":[1328],"A":[1329],"fast":[1330],"accurate":[1332],"procedure,":[1333],"preliminary":[1336],"developments":[1337],"made":[1338],"other":[1340],"groups":[1342],"doses,":[1345],"detect":[1349],"cultures":[1360],"infected":[1361],"(H1N1)":[1366],"Experiments":[1369],"distinct":[1372],"strains":[1374],"demonstrated":[1375],"potential":[1377],"analyze":[1382],"associated":[1385],"different":[1387,1403],"strains.":[1389],"appears":[1393],"very":[1396],"effective":[1397],"rapid":[1399],"screening":[1400],"strategies.":[1406]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
