{"id":"https://openalex.org/W778186545","doi":null,"title":"Role of p53 in Adaptation to the Tumor Microenvironment","display_name":"Role of p53 in Adaptation to the Tumor Microenvironment","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W778186545","mag":"778186545"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/204113","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/204113","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034241541","display_name":"Erin E. Mendoza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Erin E. Mendoza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034241541"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-adaptation","display_name":"tumor adaptation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pfkfb3","display_name":"PFKFB3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nadph-cytochrome-p450-reductase","display_name":"NADPH-cytochrome P450 reductase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5799999833106995},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.453000009059906},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.49900001287460327},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6595484018325806},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5571001768112183},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3546934723854065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2941209673881531},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.205699622631073},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.19868716597557068},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15110531449317932}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/204113","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/204113","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:778186545","doi":null,"is_oa":false,"landing_page_url":"https://arizona.openrepository.com/handle/10150/204113","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W42143944","https://openalex.org/W127907999","https://openalex.org/W183587428","https://openalex.org/W1603230122","https://openalex.org/W1640462122","https://openalex.org/W1813541406","https://openalex.org/W1821406191","https://openalex.org/W1934291382","https://openalex.org/W1963862641","https://openalex.org/W1963953060","https://openalex.org/W1970312353","https://openalex.org/W1971660417","https://openalex.org/W1972666526","https://openalex.org/W1977887541","https://openalex.org/W1986119405","https://openalex.org/W1987226074","https://openalex.org/W1988634652","https://openalex.org/W1990305582","https://openalex.org/W1997796798","https://openalex.org/W2000292756","https://openalex.org/W2002752049","https://openalex.org/W2005096273","https://openalex.org/W2006202974","https://openalex.org/W2010025550","https://openalex.org/W2011132777","https://openalex.org/W2011557948","https://openalex.org/W2013747211","https://openalex.org/W2015396179","https://openalex.org/W2015486259","https://openalex.org/W2018005037","https://openalex.org/W2024568523","https://openalex.org/W2024868015","https://openalex.org/W2026104514","https://openalex.org/W2028265989","https://openalex.org/W2028437938","https://openalex.org/W2029017796","https://openalex.org/W2029272680","https://openalex.org/W2029570717","https://openalex.org/W2029647445","https://openalex.org/W2032533550","https://openalex.org/W2033821451","https://openalex.org/W2034801324","https://openalex.org/W2036192108","https://openalex.org/W2038678542","https://openalex.org/W2042042897","https://openalex.org/W2046275434","https://openalex.org/W2046282971","https://openalex.org/W2047470479","https://openalex.org/W2058535519","https://openalex.org/W2059190026","https://openalex.org/W2060522209","https://openalex.org/W2060551076","https://openalex.org/W2060555288","https://openalex.org/W2061007863","https://openalex.org/W2065903789","https://openalex.org/W2072368664","https://openalex.org/W2073212944","https://openalex.org/W2074808685","https://openalex.org/W2076424556","https://openalex.org/W2076427320","https://openalex.org/W2077356468","https://openalex.org/W2079854321","https://openalex.org/W2082776359","https://openalex.org/W2083266848","https://openalex.org/W2085948210","https://openalex.org/W2098960013","https://openalex.org/W2099952208","https://openalex.org/W2102140960","https://openalex.org/W2102416115","https://openalex.org/W2102523308","https://openalex.org/W2104824311","https://openalex.org/W2105494151","https://openalex.org/W2106979625","https://openalex.org/W2107855685","https://openalex.org/W2108623236","https://openalex.org/W2111210558","https://openalex.org/W2111928342","https://openalex.org/W2113533381","https://openalex.org/W2117798942","https://openalex.org/W2118604693","https://openalex.org/W2119239003","https://openalex.org/W2119383587","https://openalex.org/W2122611359","https://openalex.org/W2124496728","https://openalex.org/W2125549690","https://openalex.org/W2127255821","https://openalex.org/W2127862455","https://openalex.org/W2127886703","https://openalex.org/W2127932095","https://openalex.org/W2130503287","https://openalex.org/W2132354921","https://openalex.org/W2133335733","https://openalex.org/W2143546230","https://openalex.org/W2143643440","https://openalex.org/W2146365608","https://openalex.org/W2148328056","https://openalex.org/W2148635130","https://openalex.org/W2151413135","https://openalex.org/W2162910153","https://openalex.org/W2163182836","https://openalex.org/W2163409417","https://openalex.org/W2168199397","https://openalex.org/W2175530967","https://openalex.org/W2212910615","https://openalex.org/W2316875490","https://openalex.org/W2319550775","https://openalex.org/W2402679971"],"related_works":["https://openalex.org/W7203792351","https://openalex.org/W816736599","https://openalex.org/W3026016648","https://openalex.org/W846918294","https://openalex.org/W7058101960","https://openalex.org/W7020643310","https://openalex.org/W1660844236","https://openalex.org/W2045292603","https://openalex.org/W7161797944","https://openalex.org/W3020484182"],"abstract_inverted_index":{"Tumors":[0],"cells":[1,95],"grow":[2],"in":[3,56,112,152,165,176,219,232,250,294,307],"nutrient":[4],"and":[5,8,32,39,44,54,64,76,106,122,132,139,149,189,215,302,312,331],"oxygen-deprived":[6],"microenvironments":[7],"adapt":[9,53],"to":[10,42,52,61,96,162,186,204,244,277,297,309,325],"the":[11,47,70,125,129,153,156,166,181,205,209,220,280,290,298],"suboptimal":[12],"growth":[13,34],"conditions":[14,102],"by":[15,202,265,272],"altering":[16],"their":[17,57],"metabolic":[18,130],"pathways.":[19],"The":[20,86,145,168,194,230],"adaptation":[21,118,177,296,330],"process":[22],"commonly":[23],"creates":[24],"a":[25,113,173,217,236,269],"tumor":[26,71,94,169,191,281,295,333],"phenotype":[27],"of":[28,93,128,147,155,183,196,222,247,275,315],"high":[29],"glycolytic":[30,133],"potential":[31],"aggressive":[33],"characteristics":[35],"which":[36,79,110],"facilitate":[37],"metastasis":[38],"confer":[40],"resistance":[41],"radiation":[43],"chemotherapy.":[45],"Understanding":[46],"mechanisms":[48],"that":[49,69,91,292,305,321],"allow":[50],"tumors":[51],"survive":[55],"microenvironment":[58,72,299],"is":[59],"crucial":[60],"cancer":[62],"prevention":[63],"control.":[65],"It":[66],"was":[67,199],"hypothesized":[68],"would":[73],"induce":[74],"signaling":[75,104,301],"enzymatic":[77,303],"changes,":[78],"if":[80],"manipulated":[81],"could":[82,322],"improve":[83],"treatment":[84],"outcome.":[85],"results":[87,288],"presented":[88],"here":[89],"demonstrate":[90],"exposure":[92],"chronic":[97],"low":[98],"pH":[99],"or":[100,328],"hypoxic":[101,251],"induced":[103,180,268],"cascades":[105],"altered":[107,201],"enzyme":[108],"profiles":[109],"resulted":[111],"pro-survival":[114],"phenotype.":[115],"Three":[116],"key":[117],"events":[119],"were":[120,159],"observed":[121],"included":[123],"1)":[124],"up":[126],"regulation":[127],"stress":[131],"proteins":[134,185],"AMP-activated":[135],"protein":[136,213],"kinase":[137],"(AMPK)":[138],"6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase":[140],"3":[141],"(PFKFB3),":[142],"respectfully.":[143],"2)":[144],"upregulation":[146],"p53":[148,171,259,276],"3)":[150],"changes":[151,203,291,304,317],"ratios":[154],"bioreductive":[157,197,248],"enzymes":[158,198],"also":[160,200,254],"found":[161],"be":[163,323],"important":[164],"adaptation.":[167],"suppressor":[170,282],"played":[172],"central":[174],"role":[175],"because":[178,261],"it":[179],"transcription":[182],"anti-glycolytic":[184],"control":[187],"glycolysis":[188],"minimize":[190],"cell":[192],"acidosis.":[193],"ratio":[195,221],"microenvironment.":[206],"Hypoxia":[207],"had":[208,255],"greatest":[210],"effect":[211,257,271],"on":[212,258],"levels":[214],"caused":[216],"decrease":[218],"NAD(P)H:quinone":[223],"oxidoreductase":[224],"1":[225],"(NQO1):":[226],"cytochrome":[227,233],"p450":[228,234],"reductase.":[229],"increase":[231,245],"reductase,":[235],"one":[237],"electron":[238],"bioreduction":[239],"enzyme,":[240],"has":[241],"been":[242],"shown":[243],"toxicity":[246],"drugs":[249],"tumors.":[252],"Micronutrients":[253],"an":[256],"homeostasis":[260],"increasing":[262],"NQO1":[263],"activity":[264],"riboflavin":[266],"supplementation":[267],"p53-stabilizing":[270],"enhancing":[273],"binding":[274],"NQO1,":[278],"protecting":[279],"from":[283],"degradation.":[284],"Taken":[285],"together,":[286],"these":[287,316],"indicate":[289],"occur":[293],"require":[300],"work":[306],"concert":[308],"regulate":[310],"metabolism":[311],"apoptosis.":[313],"Many":[314],"present":[318],"therapeutic":[319],"targets":[320],"exploited":[324],"enhance":[326],"therapy":[327],"prevent":[329],"subsequent":[332],"growth.":[334]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
