{"id":"https://openalex.org/W77810648","doi":null,"title":"Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias.","display_name":"Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias.","publication_year":1994,"publication_date":"1994-05-01","ids":{"openalex":"https://openalex.org/W77810648","mag":"77810648","pmid":"https://pubmed.ncbi.nlm.nih.gov/8182933"},"language":"en","primary_location":{"id":"pmid:8182933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8182933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053560614","display_name":"Paolo Corradini","orcid":"https://orcid.org/0000-0002-9186-1353","observed_orcids":["https://orcid.org/0000-0002-9186-1353"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Corradini","raw_affiliation_strings":["Department of Pathology, College of Physicians and Surgeons, Columbia University, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Physicians and Surgeons, Columbia University, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006640724","display_name":"Giorgio Inghirami","orcid":"https://orcid.org/0000-0001-5566-0864","observed_orcids":["https://orcid.org/0000-0001-5566-0864","https://orcid.org/0000-0002-5298-6516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Inghirami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112261034","display_name":"Monica Astolfi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Astolfi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076353357","display_name":"Marco Ladetto","orcid":"https://orcid.org/0000-0002-8283-2681","observed_orcids":["https://orcid.org/0000-0002-8283-2681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ladetto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027011770","display_name":"Claudia Voena","orcid":"https://orcid.org/0000-0002-1324-1431","observed_orcids":["https://orcid.org/0000-0002-1324-1431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Voena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053450483","display_name":"Paola Fabiola Ballerini","orcid":"https://orcid.org/0009-0005-4844-7762","observed_orcids":["https://orcid.org/0009-0005-4844-7762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Ballerini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015664805","display_name":"Wei Jun Gu","orcid":"https://orcid.org/0000-0002-1480-2368","observed_orcids":["https://orcid.org/0000-0002-1480-2368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002202838","display_name":"Kenneth Nilsson","orcid":"https://orcid.org/0000-0002-0093-5725","observed_orcids":["https://orcid.org/0000-0002-0093-5725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nilsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109031136","display_name":"Daniel M Knowles Ii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Knowles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018139001","display_name":"Mario Boccadoro","orcid":"https://orcid.org/0000-0001-8130-5209","observed_orcids":["https://orcid.org/0000-0001-8130-5209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Boccadoro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.6025,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.96753598,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"5","first_page":"758","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-cell-dyscrasia","display_name":"plasma cell dyscrasia","score":0.8619999885559082},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/plasma-cell-leukemia","display_name":"plasma cell leukemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/monoclonal-gammopathy-of-undetermined-significance","display_name":"monoclonal gammopathy of undetermined significance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ras-oncogene-mutations","display_name":"ras oncogene mutations","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/disease-aggressiveness","display_name":"disease aggressiveness","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C113775271","wikidata":"https://www.wikidata.org/wiki/Q3709969","display_name":"Dyscrasia","level":4,"score":0.7609838247299194},{"id":"https://openalex.org/C2780411336","wikidata":"https://www.wikidata.org/wiki/Q1706485","display_name":"Plasma cell dyscrasia","level":4,"score":0.7064205408096313},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.639894962310791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6255993843078613},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5399646162986755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5094307065010071},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5067992806434631},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.49686959385871887},{"id":"https://openalex.org/C2780353925","wikidata":"https://www.wikidata.org/wiki/Q7201765","display_name":"Plasma cell leukemia","level":3,"score":0.4330378770828247},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3874633014202118},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.35970038175582886},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.3481104075908661},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2682865858078003},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2443283498287201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22554367780685425},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18489685654640198},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13934937119483948},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007952","descriptor_name":"Leukemia, Plasma Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010265","descriptor_name":"Paraproteinemias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:8182933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8182933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/121911","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/121911","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/36996","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/36996","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:77810648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8182933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6785039256","display_name":"MOLECULAR PATHOLOGY OF HUMAN LYMPOID MALIGNANCIES","funder_award_id":"R01CA044029","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7217822240","https://openalex.org/W7217177600","https://openalex.org/W7217788266","https://openalex.org/W7218099102","https://openalex.org/W78054197","https://openalex.org/W66769261","https://openalex.org/W2159114387","https://openalex.org/W2032611151","https://openalex.org/W2077533222","https://openalex.org/W2399293951"],"abstract_inverted_index":{"The":[0],"role":[1,175],"of":[2,6,18,40,47,56,69,77,95,101,116,128],"loss":[3,39,115],"or":[4],"inactivation":[5,165],"the":[7,16,35,38,45,54,92,99,105],"retinoblastoma":[8],"(Rb1)":[9],"and":[10,44,85,119,126,130,144,148,163],"p53":[11,57,120,149,164],"tumor":[12,180],"suppressor":[13],"genes":[14],"in":[15,66,124,138,179],"pathogenesis":[17],"various":[19],"human":[20],"malignancies":[21],"has":[22],"been":[23],"well":[24,52,152],"established,":[25],"yet":[26],"little":[27],"is":[28],"known":[29],"regarding":[30],"plasma":[31,70,87,170],"cell":[32,71,88,171],"dyscrasias.":[33],"In":[34,91,140],"present":[36],"study,":[37],"Rb1":[41,48,117,147,162],"protein":[42,118],"expression,":[43],"presence":[46,55],"gene":[49],"rearrangements":[50],"as":[51,53,151,153],"somatic":[58],"mutations":[59,121,155],"(exons":[60],"5":[61],"through":[62],"9)":[63],"were":[64,156],"investigated":[65],"a":[67,174],"panel":[68,94],"dyscrasias,":[72,172],"including":[73],"15":[74],"monoclonal":[75],"gammopathies":[76],"undetermined":[78],"significance":[79],"(MGUS),":[80],"63":[81],"multiple":[82],"myelomas":[83],"(MM),":[84],"18":[86],"leukemias":[89],"(PCL).":[90],"same":[93],"cases,":[96,146],"we":[97],"established":[98],"frequency":[100],"ras":[102,154],"oncogene":[103],"mutations,":[104],"main":[106],"genetic":[107],"lesion":[108,135],"associated":[109,167],"with":[110,168],"MM.":[111],"We":[112],"report":[113],"that":[114,161],"are":[122,166],"detectable":[123],"34.7":[125],"9.8%":[127],"MM":[129],"PCL":[131,145],"primary":[132],"cases;":[133],"no":[134],"was":[136],"found":[137],"MGUS.":[139],"advanced":[141],"stage":[142],"MM,":[143],"inactivation,":[150],"detected.":[157],"Our":[158],"findings":[159],"show":[160],"aggressive":[169],"suggesting":[173],"for":[176],"these":[177],"lesions":[178],"progression":[181],"rather":[182],"than":[183],"initiation.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
