{"id":"https://openalex.org/W77783221","doi":null,"title":"Microglioma, a histiocytic neoplasm of the central nervous system.","display_name":"Microglioma, a histiocytic neoplasm of the central nervous system.","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W77783221","mag":"77783221","pmid":"https://pubmed.ncbi.nlm.nih.gov/8685234"},"language":"en","primary_location":{"id":"pmid:8685234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8685234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106084260","display_name":"Christine Marie Hulette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C M Hulette","raw_affiliation_strings":["Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5106084260"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.00735835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"3","first_page":"316","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histiocytic-neoplasms","display_name":"histiocytic neoplasms","score":0.9169999957084656},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8190000057220459},{"id":"https://openalex.org/keywords/central-nervous-system-tumors","display_name":"central nervous system tumors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.7260000109672546},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9039999842643738},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8050000071525574},{"id":"https://openalex.org/keywords/differential-diagnosis-from-lymphoma","display_name":"differential diagnosis from lymphoma","score":0.6819999814033508},{"id":"https://openalex.org/keywords/gliomatosis-cerebri","display_name":"gliomatosis cerebri","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.8469353914260864},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6662455201148987},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.6450325846672058},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5424725413322449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5284055471420288},{"id":"https://openalex.org/C2780635560","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplasm","level":2,"score":0.49412277340888977},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4917342960834503},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.46460407972335815},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.46256858110427856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097382","descriptor_name":"CD68 Molecule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002367","descriptor_name":"Ricinus communis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010947","descriptor_name":"Plants, Toxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015214","descriptor_name":"Antigens, Differentiation, Myelomonocytic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018219","descriptor_name":"Histiocytoma, Benign Fibrous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018219","descriptor_name":"Histiocytoma, Benign Fibrous","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D037121","descriptor_name":"Plant Lectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8685234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8685234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Case Reports"},{"id":"mag:77783221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8685234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1978887804","https://openalex.org/W1988295204","https://openalex.org/W2033381671"],"related_works":["https://openalex.org/W2406026899","https://openalex.org/W2033858037","https://openalex.org/W2413822707","https://openalex.org/W2020452031","https://openalex.org/W2019830493","https://openalex.org/W2052313084","https://openalex.org/W2071942154","https://openalex.org/W2437145421","https://openalex.org/W2077824588","https://openalex.org/W7006454621"],"abstract_inverted_index":{"Neuropathologists":[0],"have":[1],"long":[2],"suspected":[3],"the":[4,11,15,20,35,52,56,88,105,109,113,117,127,131,136,139,150],"existence":[5],"of":[6,19,27,37,55,71,108,138,191],"a":[7,45,61,68,97,174],"tumor":[8,31,118,140,179],"derived":[9],"from":[10,104,149,206],"microglia,":[12],"which":[13,102],"are":[14],"resident":[16],"immunocompetent":[17],"cells":[18,119,128,157,180],"central":[21],"nervous":[22],"system.":[23],"Previously,":[24],"definitive":[25],"characterization":[26],"this":[28,198],"rare":[29,199],"putative":[30],"was":[32,60,94,141],"hampered":[33],"by":[34],"lack":[36],"precise":[38,192],"immunohistochemical":[39,53,193],"reagents.":[40],"We":[41],"herein":[42],"report":[43],"on":[44],"patient":[46,59,81],"with":[47,67,160,172],"microglioma,":[48],"and":[49,76,93,126,163,170,201,208],"we":[50],"define":[51],"characteristics":[54],"tumor.":[57],"The":[58,80,155,178,188],"50-year-old":[62],"white":[63],"woman":[64],"who":[65],"presented":[66],"1-year":[69],"history":[70],"progressive":[72],"paresthesia,":[73],"visual":[74],"difficulties,":[75],"cranial":[77],"nerve":[78],"abnormalities.":[79],"died":[82],"in":[83],"June":[84],"1972.":[85],"At":[86],"autopsy,":[87],"brain":[89,132],"weighed":[90],"1540":[91],"grams":[92],"remarkable":[95],"for":[96,168,176,183],"diffusely":[98,129],"infiltrating":[99],"periventricular":[100],"tumor,":[101],"extended":[103],"rostral":[106],"tip":[107],"lateral":[110],"ventricles":[111],"through":[112],"spinal":[114],"cord.":[115],"Microscopically,":[116],"had":[120],"extremely":[121],"long,":[122],"slender,":[123],"twisted":[124],"nuclei,":[125],"infiltrated":[130],"parenchyma":[133],"so":[134],"that":[135],"extent":[137],"difficult":[142],"to":[143],"determine.":[144],"Formalin-fixed,":[145],"paraffin-embedded":[146],"tissue":[147],"blocks":[148],"neuropathology":[151],"archives":[152],"were":[153],"studied.":[154],"neoplastic":[156],"stained":[158,181],"intensely":[159],"CD68":[161],"(KP1)":[162],"Ricinus":[164],"communis":[165],"agglutinin-120":[166],"markers":[167],"microglia":[169],"also":[171],"HAM-56,":[173],"marker":[175],"macrophages.":[177],"negative":[182],"glial":[184],"fibrillary":[185],"acidic":[186],"protein.":[187],"recent":[189],"availability":[190],"reagents":[194],"has":[195,202],"clearly":[196],"defined":[197],"neoplasm":[200],"facilitated":[203],"reliable":[204],"distinction":[205],"lymphoma":[207],"gliomatosis":[209],"cerebri.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}