{"id":"https://openalex.org/W776995397","doi":"https://doi.org/10.1016/s0140-6736(96)03409-5","title":"Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin","display_name":"Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W776995397","doi":"https://doi.org/10.1016/s0140-6736(96)03409-5","mag":"776995397","pmid":"https://pubmed.ncbi.nlm.nih.gov/8874455"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(96)03409-5","doi":"https://doi.org/10.1016/s0140-6736(96)03409-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(96)03409-5","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W776995397"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160741197","display_name":"S.J. Arnott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S.J. Arnott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056345420","display_name":"David Cunningham","orcid":"https://orcid.org/0000-0001-5158-1069","observed_orcids":["https://orcid.org/0000-0001-5158-1069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Cunningham","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5158-1069","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160823981","display_name":"James Gallagher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Gallagher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160766237","display_name":"Richard Gray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Gray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160825041","display_name":"J D Hardcastle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Hardcastle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112808882","display_name":"J. Houghton","orcid":"https://orcid.org/0000-0003-4255-3044","observed_orcids":["https://orcid.org/0000-0003-4255-3044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob L. Houghton","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4255-3044","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160932858","display_name":"R.D. James","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.D. James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070446667","display_name":"Teresa Lennon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Lennon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160916585","display_name":"Helen Meadows","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Meadows","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064438616","display_name":"Jean Mossman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Mossman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109980142","display_name":"Northover Jma.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Northover Jma.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087993028","display_name":"Morgan Dal","orcid":"https://orcid.org/0000-0002-5599-954X","observed_orcids":["https://orcid.org/0000-0002-5599-954X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morgan Dal.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160772257","display_name":"P N Plowman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P N Plowman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Mark Slevin","orcid":"https://orcid.org/0000-0003-3767-4861","observed_orcids":["https://orcid.org/0000-0003-3767-4861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Slevin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3767-4861","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5160741197"],"corresponding_institution_ids":[],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":22.8388,"has_fulltext":false,"cited_by_count":1136,"citation_normalized_percentile":{"value":0.99754326,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"348","issue":"9034","first_page":"1049","last_page":"1054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anal-squamous-cell-carcinoma","display_name":"anal squamous cell carcinoma","score":0.746999979019165},{"id":"https://openalex.org/keywords/radiotherapy-alone","display_name":"radiotherapy alone","score":0.6800000071525574},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.9039999842643738},{"id":"https://openalex.org/keywords/local-tumor-control","display_name":"local tumor control","score":0.7680000066757202},{"id":"https://openalex.org/keywords/local-failure","display_name":"local failure","score":0.7900000214576721},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cause-specific-survival","display_name":"cause-specific survival","score":0.8889999985694885},{"id":"https://openalex.org/keywords/treatment-morbidity","display_name":"treatment morbidity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/salvage-surgery","display_name":"salvage surgery","score":0.6660000085830688},{"id":"https://openalex.org/keywords/non-surgical-management","display_name":"non-surgical management","score":0.6740000247955322},{"id":"https://openalex.org/keywords/continuous-infusion-chemotherapy","display_name":"continuous infusion chemotherapy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/radiotherapy-boost","display_name":"boost radiotherapy","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.8405057191848755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.825180172920227},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.6698020100593567},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.6524801850318909},{"id":"https://openalex.org/C2779840525","wikidata":"https://www.wikidata.org/wiki/Q484827","display_name":"Anal cancer","level":3,"score":0.6496742963790894},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5578998923301697},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3842860162258148},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36460942029953003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3091542720794678}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001005","descriptor_name":"Anus Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001005","descriptor_name":"Anus Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001005","descriptor_name":"Anus Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008937","descriptor_name":"Mitomycins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0140-6736(96)03409-5","doi":"https://doi.org/10.1016/s0140-6736(96)03409-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(96)03409-5","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:8874455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8874455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Clinical Trial"},{"id":"mag:2512810768","doi":null,"is_oa":false,"landing_page_url":"https://www.ctsu.ox.ac.uk/publications/326948","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Lancet","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1605543334","https://openalex.org/W1972069596","https://openalex.org/W1984232770","https://openalex.org/W1988804372","https://openalex.org/W2004367809","https://openalex.org/W2013073551","https://openalex.org/W2020463670","https://openalex.org/W2025289696","https://openalex.org/W2037783145","https://openalex.org/W2039217762","https://openalex.org/W2048663701","https://openalex.org/W2052910344","https://openalex.org/W2062384375","https://openalex.org/W2067126590","https://openalex.org/W2067543827","https://openalex.org/W2069640589","https://openalex.org/W2083495913","https://openalex.org/W2137101661","https://openalex.org/W2143774419","https://openalex.org/W2148723888","https://openalex.org/W2333908381","https://openalex.org/W2474205938","https://openalex.org/W2496710861","https://openalex.org/W6635980356"],"related_works":["https://openalex.org/W2007485901","https://openalex.org/W1974234666","https://openalex.org/W2092407000","https://openalex.org/W1947979503","https://openalex.org/W2141405230","https://openalex.org/W2029919879","https://openalex.org/W2044031515","https://openalex.org/W953442350","https://openalex.org/W2020296791"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":38},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":46},{"year":2020,"cited_by_count":39},{"year":2019,"cited_by_count":42},{"year":2018,"cited_by_count":46},{"year":2017,"cited_by_count":54},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":50},{"year":2014,"cited_by_count":59},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":68}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
