{"id":"https://openalex.org/W776806191","doi":null,"title":"Investigating the role of an identified Pi-bulge in IpaD on Shigella flexneri virulence","display_name":"Investigating the role of an identified Pi-bulge in IpaD on Shigella flexneri virulence","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W776806191","mag":"776806191"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.usu.edu:researchweek-1118","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usu.edu/researchweek/ResearchWeek2015/All2015/119","pdf_url":null,"source":{"id":"https://openalex.org/S4377196327","display_name":"Digital Commons - USU (Utah State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121980950","host_organization_name":"Utah State University","host_organization_lineage":["https://openalex.org/I121980950"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Student Research Symposium","raw_type":"text"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007891928","display_name":"T. Carson Jessop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Carson Jessop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079721014","display_name":"Nicholas E. Dickenson","orcid":"https://orcid.org/0000-0003-1572-6077","observed_orcids":["https://orcid.org/0000-0003-1572-6077"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas E. Dickenson","raw_affiliation_strings":["Oklahoma State University, Stillwater, United States"],"raw_orcid":"https://orcid.org/0000-0003-1572-6077","affiliations":[{"raw_affiliation_string":"Oklahoma State University, Stillwater, United States","institution_ids":["https://openalex.org/I115475287"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02521008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shigella-flexneri","display_name":"Shigella flexneri","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ipad","display_name":"iPad","score":0.9950000047683716},{"id":"https://openalex.org/keywords/type-iii-secretion-system","display_name":"type III secretion system","score":0.8090000152587891},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.5839999914169312},{"id":"https://openalex.org/keywords/point-mutants","display_name":"point mutants","score":0.5860000252723694},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/effector-secretion","display_name":"effector secretion","score":0.7400000095367432},{"id":"https://openalex.org/keywords/host-cell-invasion","display_name":"host cell invasion","score":0.5920000076293945},{"id":"https://openalex.org/keywords/shigellosis","display_name":"shigellosis","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2781217973","wikidata":"https://www.wikidata.org/wiki/Q1644417","display_name":"Shigella flexneri","level":4,"score":0.8679747581481934},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7949919700622559},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.575311005115509},{"id":"https://openalex.org/C2776986154","wikidata":"https://www.wikidata.org/wiki/Q131029","display_name":"Shigella","level":4,"score":0.5473771095275879},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4266808331012726},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41132399439811707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2855536639690399},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12745001912117004},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.10423657298088074},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07164525985717773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.usu.edu:researchweek-1118","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usu.edu/researchweek/ResearchWeek2015/All2015/119","pdf_url":null,"source":{"id":"https://openalex.org/S4377196327","display_name":"Digital Commons - USU (Utah State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121980950","host_organization_name":"Utah State University","host_organization_lineage":["https://openalex.org/I121980950"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Student Research Symposium","raw_type":"text"},{"id":"mag:776806191","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usu.edu/chem_facpub/668/","pdf_url":null,"source":{"id":"https://openalex.org/S4306420948","display_name":"Student Research Symposium","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Student Research Symposium","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2614020071","https://openalex.org/W2056446295","https://openalex.org/W2023267769","https://openalex.org/W2050472879","https://openalex.org/W2123868514","https://openalex.org/W4401062211","https://openalex.org/W2122203682","https://openalex.org/W2338303800","https://openalex.org/W7075731950","https://openalex.org/W2090334490"],"abstract_inverted_index":{"Shigella":[0,12,154,221],"flexneri":[1],"is":[2,46,54],"a":[3,14,22,47,99,133,195],"bacterial":[4,27],"pathogen":[5],"that,":[6],"upon":[7],"infection,":[8],"causes":[9],"bacillary":[10],"dysentery.":[11],"uses":[13],"Type":[15],"III":[16],"secretion":[17,59],"system":[18],"(T3SS)":[19],"which":[20,204],"provides":[21],"unidirectional":[23],"conduit":[24],"between":[25],"the":[26,38,58,64,91,124,144,158,215],"and":[28,53,76,139,153,213],"host":[29,39,92],"cell":[30],"cytoplasm,":[31],"allowing":[32],"translocation":[33],"of":[34,50,60,101,128,135,146,217],"effector":[35,61],"proteins":[36,62],"into":[37],"cell.":[40],"Invasion":[41],"Plasmid":[42],"Antigen":[43],"D":[44],"(IpaD)":[45],"key":[48,196],"component":[49],"this":[51],"complex":[52],"responsible":[55,122,198],"for":[56,123,177,199],"controlling":[57],"through":[63],"immature":[65],"apparatus.":[66],"This":[67],"role":[68],"appears":[69],"to":[70,73,110,120,142,162,183],"be":[71,78,121],"central":[72],"Shigella's":[74],"virulence":[75],"may":[77],"regulated":[79],"by":[80],"structural":[81,126,207],"changes":[82],"that":[83,107,117,189],"follow":[84],"IpaD":[85,116,159],"interaction":[86],"with":[87,181],"bile":[88,178,201,210],"salts":[89,202],"in":[90,172,192,203],"GI":[93],"tract.":[94],"Here,":[95],"we":[96,118,131,190],"report":[97],"on":[98,149,167],"series":[100],"studies":[102],"characterizing":[103],"specific":[104],"point":[105],"mutants":[106,160],"were":[108],"designed":[109],"stabilize":[111],"an":[112],"identified":[113],"Pi-bulge":[114],"within":[115],"believe":[119],"observed":[125],"flexibility":[127],"IpaD.":[129],"Specifically,":[130],"used":[132],"combination":[134],"spectroscopic":[136],"biophysical":[137],"methods":[138],"phenotype":[140],"assays":[141],"investigate":[143],"effects":[145],"each":[147],"mutation":[148],"both":[150],"protein":[151,168],"structure":[152],"virulence.":[155,184],"Interestingly,":[156],"while":[157],"appear":[161],"have":[163,191],"little":[164],"overall":[165],"effect":[166],"structure,":[169],"they":[170],"result":[171],"significant":[173],"differences":[174],"when":[175],"tested":[176],"salt":[179,211],"sensitivity":[180,212],"respect":[182],"Together,":[185],"these":[186],"results":[187],"suggest":[188],"fact":[193],"targeted":[194],"region":[197],"sensing":[200],"minor":[205],"local":[206],"perturbations":[208],"reduce/eliminate":[209],"reduce":[214],"risk":[216],"cellular":[218],"invasion":[219],"following":[220],"exposure.":[222]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2016-06-24T00:00:00"}
