{"id":"https://openalex.org/W776193763","doi":null,"title":"Non-invasive near infrared spectroscopy : a tool for measuring cerebral oxygenation and metabolism in patients with traumatic brain injury","display_name":"Non-invasive near infrared spectroscopy : a tool for measuring cerebral oxygenation and metabolism in patients with traumatic brain injury","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W776193763","mag":"776193763"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1444075","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1444075/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, University of London.","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000884026","display_name":"Martin M. Tisdall","orcid":"https://orcid.org/0000-0001-8880-8386","observed_orcids":["https://orcid.org/0000-0001-8880-8386"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M.M. Tisdall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000884026"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9319999814033508},{"id":"https://openalex.org/keywords/near-infrared-spectroscopy","display_name":"near-infrared spectroscopy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cerebral-oxygenation","display_name":"cerebral oxygenation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cerebral-metabolism","display_name":"brain metabolism","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mitochondrial-redox-state","display_name":"mitochondrial redox state","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neurocritical-care","display_name":"neurocritical care","score":0.5839999914169312},{"id":"https://openalex.org/keywords/hemoglobin-levels","display_name":"hemoglobin levels","score":0.8029999732971191},{"id":"https://openalex.org/keywords/neuromonitoring","display_name":"neuromonitoring","score":0.5040000081062317},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7841714024543762},{"id":"https://openalex.org/C165455791","wikidata":"https://www.wikidata.org/wiki/Q7002299","display_name":"Neurointensive care","level":2,"score":0.5957656502723694},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.5377943515777588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5274878740310669},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36057019233703613},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32645049691200256},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.31598079204559326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.156605064868927},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1444075","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1444075/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, University of London.","raw_type":"Thesis"},{"id":"mag:776193763","doi":null,"is_oa":false,"landing_page_url":"https://www.ucl.ac.uk/medphys/research/borl/pub/theses/docs/mtisdall.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306508234","display_name":"Doctoral thesis, University of London.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, University of London.","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":244,"referenced_works":["https://openalex.org/W20214996","https://openalex.org/W60315446","https://openalex.org/W75190577","https://openalex.org/W87756692","https://openalex.org/W107606605","https://openalex.org/W115497294","https://openalex.org/W150865866","https://openalex.org/W152898463","https://openalex.org/W167331988","https://openalex.org/W190446858","https://openalex.org/W196857102","https://openalex.org/W221088374","https://openalex.org/W282907006","https://openalex.org/W335264449","https://openalex.org/W1491555408","https://openalex.org/W1504518491","https://openalex.org/W1603121691","https://openalex.org/W1629254220","https://openalex.org/W1666127819","https://openalex.org/W1677366313","https://openalex.org/W1870965654","https://openalex.org/W1889260838","https://openalex.org/W1963722284","https://openalex.org/W1963760549","https://openalex.org/W1963908945","https://openalex.org/W1966187076","https://openalex.org/W1966212698","https://openalex.org/W1966558330","https://openalex.org/W1967308296","https://openalex.org/W1968112618","https://openalex.org/W1969243096","https://openalex.org/W1970802958","https://openalex.org/W1970808650","https://openalex.org/W1971144058","https://openalex.org/W1972155177","https://openalex.org/W1972333723","https://openalex.org/W1972979049","https://openalex.org/W1974237962","https://openalex.org/W1974572661","https://openalex.org/W1977001142","https://openalex.org/W1978256141","https://openalex.org/W1978387821","https://openalex.org/W1979333101","https://openalex.org/W1979454915","https://openalex.org/W1980574163","https://openalex.org/W1984917592","https://openalex.org/W1985994475","https://openalex.org/W1986301617","https://openalex.org/W1987825285","https://openalex.org/W1987939219","https://openalex.org/W1988751367","https://openalex.org/W1988808659","https://openalex.org/W1990158364","https://openalex.org/W1991328496","https://openalex.org/W1991870505","https://openalex.org/W1992358002","https://openalex.org/W1992744269","https://openalex.org/W1992902180","https://openalex.org/W1993173822","https://openalex.org/W1993273876","https://openalex.org/W1993829914","https://openalex.org/W1993931311","https://openalex.org/W1995061172","https://openalex.org/W1995388837","https://openalex.org/W1996516846","https://openalex.org/W1996782427","https://openalex.org/W2000167387","https://openalex.org/W2000249415","https://openalex.org/W2002137001","https://openalex.org/W2002664886","https://openalex.org/W2003041135","https://openalex.org/W2003890250","https://openalex.org/W2003987283","https://openalex.org/W2004266373","https://openalex.org/W2004492214","https://openalex.org/W2005333810","https://openalex.org/W2005686740","https://openalex.org/W2006176036","https://openalex.org/W2007420574","https://openalex.org/W2007436515","https://openalex.org/W2007897070","https://openalex.org/W2008008093","https://openalex.org/W2011305231","https://openalex.org/W2011550515","https://openalex.org/W2013703361","https://openalex.org/W2015719898","https://openalex.org/W2016519751","https://openalex.org/W2016575029","https://openalex.org/W2016658793","https://openalex.org/W2018235171","https://openalex.org/W2020528079","https://openalex.org/W2020748457","https://openalex.org/W2021314302","https://openalex.org/W2021524486","https://openalex.org/W2022208103","https://openalex.org/W2023257111","https://openalex.org/W2025627034","https://openalex.org/W2025640911","https://openalex.org/W2026057935","https://openalex.org/W2027141603","https://openalex.org/W2027403685","https://openalex.org/W2031375851","https://openalex.org/W2032369130","https://openalex.org/W2032656032","https://openalex.org/W2032919321","https://openalex.org/W2033607185","https://openalex.org/W2034004233","https://openalex.org/W2035750459","https://openalex.org/W2036456714","https://openalex.org/W2036829402","https://openalex.org/W2037426203","https://openalex.org/W2039632091","https://openalex.org/W2043260410","https://openalex.org/W2044480877","https://openalex.org/W2045663952","https://openalex.org/W2046479752","https://openalex.org/W2046955636","https://openalex.org/W2047229668","https://openalex.org/W2048083256","https://openalex.org/W2048238303","https://openalex.org/W2050235583","https://openalex.org/W2051395367","https://openalex.org/W2051418496","https://openalex.org/W2053022094","https://openalex.org/W2053356496","https://openalex.org/W2053620856","https://openalex.org/W2054257807","https://openalex.org/W2055134456","https://openalex.org/W2055442318","https://openalex.org/W2057377618","https://openalex.org/W2058207687","https://openalex.org/W2059092640","https://openalex.org/W2060382468","https://openalex.org/W2060474457","https://openalex.org/W2060797100","https://openalex.org/W2061628772","https://openalex.org/W2061673532","https://openalex.org/W2063537428","https://openalex.org/W2064527191","https://openalex.org/W2064669264","https://openalex.org/W2065397229","https://openalex.org/W2065758187","https://openalex.org/W2068365554","https://openalex.org/W2068997428","https://openalex.org/W2069863847","https://openalex.org/W2070139095","https://openalex.org/W2073082427","https://openalex.org/W2074846645","https://openalex.org/W2074949491","https://openalex.org/W2075306607","https://openalex.org/W2075881701","https://openalex.org/W2077754887","https://openalex.org/W2079036536","https://openalex.org/W2079108392","https://openalex.org/W2080200919","https://openalex.org/W2080528340","https://openalex.org/W2082498537","https://openalex.org/W2083554277","https://openalex.org/W2084962044","https://openalex.org/W2085022339","https://openalex.org/W2088301798","https://openalex.org/W2088869039","https://openalex.org/W2090816603","https://openalex.org/W2090868746","https://openalex.org/W2092122589","https://openalex.org/W2092624051","https://openalex.org/W2092635505","https://openalex.org/W2094099438","https://openalex.org/W2094826936","https://openalex.org/W2097552051","https://openalex.org/W2097860587","https://openalex.org/W2098725311","https://openalex.org/W2101220293","https://openalex.org/W2103338199","https://openalex.org/W2104537018","https://openalex.org/W2105333849","https://openalex.org/W2105895682","https://openalex.org/W2106021743","https://openalex.org/W2109095295","https://openalex.org/W2114510322","https://openalex.org/W2115217673","https://openalex.org/W2115577166","https://openalex.org/W2115968594","https://openalex.org/W2116666330","https://openalex.org/W2117047003","https://openalex.org/W2117303077","https://openalex.org/W2117674055","https://openalex.org/W2117768542","https://openalex.org/W2121552348","https://openalex.org/W2122323045","https://openalex.org/W2122674811","https://openalex.org/W2123265078","https://openalex.org/W2123351961","https://openalex.org/W2123894485","https://openalex.org/W2124888829","https://openalex.org/W2128712943","https://openalex.org/W2133294372","https://openalex.org/W2133941411","https://openalex.org/W2133968738","https://openalex.org/W2135048288","https://openalex.org/W2135781323","https://openalex.org/W2135822356","https://openalex.org/W2137163826","https://openalex.org/W2137523819","https://openalex.org/W2138360835","https://openalex.org/W2139684042","https://openalex.org/W2143224908","https://openalex.org/W2144446798","https://openalex.org/W2145903696","https://openalex.org/W2147291804","https://openalex.org/W2147846399","https://openalex.org/W2149812315","https://openalex.org/W2149877908","https://openalex.org/W2150264392","https://openalex.org/W2150652100","https://openalex.org/W2150833402","https://openalex.org/W2154634289","https://openalex.org/W2157158112","https://openalex.org/W2157757992","https://openalex.org/W2158268887","https://openalex.org/W2158752949","https://openalex.org/W2159827427","https://openalex.org/W2162892324","https://openalex.org/W2166860948","https://openalex.org/W2167374285","https://openalex.org/W2168277699","https://openalex.org/W2169100471","https://openalex.org/W2169355774","https://openalex.org/W2171723910","https://openalex.org/W2172088959","https://openalex.org/W2226184623","https://openalex.org/W2264376134","https://openalex.org/W2282196320","https://openalex.org/W2284025847","https://openalex.org/W2344925548","https://openalex.org/W2410819417","https://openalex.org/W2413315557","https://openalex.org/W2415728148","https://openalex.org/W2440088646","https://openalex.org/W2464538023","https://openalex.org/W2526511921","https://openalex.org/W3158470188","https://openalex.org/W3199613862","https://openalex.org/W4376595788"],"related_works":["https://openalex.org/W2011024894","https://openalex.org/W2790409223","https://openalex.org/W1983905098","https://openalex.org/W2606416336","https://openalex.org/W3133083263","https://openalex.org/W2700057978","https://openalex.org/W2957333218","https://openalex.org/W7126931333","https://openalex.org/W3173263034","https://openalex.org/W2013661948"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1],"injury":[2],"(TBI)":[3],"causes":[4],"significant":[5,29],"morbidity":[6],"and":[7,46,55,67,82,118,146,164,168,172,195,214,246,271,287],"mortality.":[8],"Modern":[9],"neurocritical":[10,297],"care":[11,298],"management":[12],"utilises":[13],"several":[14],"monitoring":[15,74,107,155,170,259],"techniques":[16,27],"to":[17,41,78,203,209,215,225,230,238,291],"identify":[18],"or":[19,134],"predict":[20],"secondary":[21],"insults":[22],"but":[23],"many":[24,63],"of":[25,64,80,144,150,187,207,267,274],"these":[26,65,211],"have":[28],"limitations.":[30],"The":[31],"ideal":[32],"cerebral":[33,73,258,283],"monitor":[34,87,239,280],"would":[35],"be":[36],"a":[37,72],"non-invasive":[38,265],"system":[39],"able":[40],"provide":[42],"realtime":[43],"quantitative":[44],"haemodynamic":[45],"metabolic":[47,219],"information":[48],"at":[49],"multiple":[50],"sites":[51],"with":[52,157,241,253],"high":[53],"temporal":[54],"spatial":[56],"resolution.":[57],"Near":[58],"infrared":[59],"spectroscopy":[60],"(NIRS)":[61],"fulfils":[62],"requirements":[66],"has":[68,288],"great":[69],"potential":[70,290],"as":[71,109],"tool.":[75],"In":[76],"addition":[77],"measurements":[79,183],"oxy-":[81],"deoxy-haemoglobin":[83],"concentration,":[84],"NIRS":[85,182,208,235,249,278],"can":[86,279],"changes":[88,95,129,191,281],"in":[89,96,114,130,147,161,176,184,192,201,282],"mitochondrial":[90,268],"redox":[91,269,276],"state":[92,270],"by":[93],"measuring":[94],"oxidised":[97],"cytochrome":[98],"c":[99],"oxidase":[100],"(oxCCO)":[101],"concentration.":[102],"This":[103,139],"is":[104,111,166,236],"an":[105],"attractive":[106],"target":[108],"it":[110],"intimately":[112],"involved":[113],"adenosine":[115],"triphosphate":[116],"synthesis":[117],"cellular":[119,275],"homeostasis,":[120],"yet":[121],"few":[122],"studies":[123],"exist":[124],"which":[125],"investigate":[126,226],"oxCCO":[127,151,232],"concentration":[128,152,233],"either":[131],"the":[132,142,185,205,217,227,289,296],"normal":[133],"injured":[135],"adult":[136],"human":[137],"brain.":[138],"thesis":[140],"explores":[141],"use":[143],"NIRS,":[145],"particular":[148],"measurement":[149],"changes,":[153],"for":[154],"patients":[156,240],"TBI.":[158],"Cerebral":[159],"metabolism":[160],"both":[162],"health":[163],"TBI":[165,177,242,286],"described":[167,200],"current":[169],"tools":[171],"treatment":[173],"strategies":[174,294],"used":[175,229,237],"are":[178,199,223,251,262],"discussed.":[179],"Studies":[180],"investigating":[181],"brains":[186],"healthy":[188],"volunteers":[189],"during":[190,243],"arterial":[193],"oxygen":[194],"carbon":[196],"dioxide":[197],"tension":[198],"order":[202],"determine":[204],"ability":[206],"detect":[210],"physiological":[212],"perturbations":[213],"characterise":[216],"resulting":[218],"changes.":[220,234],"Spectroscopic":[221],"data":[222],"analysed":[224],"methodology":[228],"calculate":[231],"normobaric":[244],"hyperoxygenation":[245],"non-invasively":[247],"measured":[248],"variables":[250],"compared":[252],"those":[254],"acquired":[255],"using":[256],"invasive":[257,272],"devices.":[260],"Correlations":[261],"shown":[263],"between":[264],"measures":[266,273],"state.":[277],"physiology":[284],"after":[285],"guide":[292],"neuroprotective":[293],"on":[295],"unit.":[299]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}