{"id":"https://openalex.org/W77569205","doi":null,"title":"Macrophage function in chronic experimental alcoholism. I. Modulation of surface receptors and phagocytosis.","display_name":"Macrophage function in chronic experimental alcoholism. I. Modulation of surface receptors and phagocytosis.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W77569205","mag":"77569205","pmid":"https://pubmed.ncbi.nlm.nih.gov/2974831","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385479"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1385479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385479","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035940340","display_name":"Omar Bagasra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O Bagasra","raw_affiliation_strings":["Department of Microbiology, University of Medicine & Dentistry of New Jersey, School of Osteopathic Medicine, Camden 08103-1505"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Medicine & Dentistry of New Jersey, School of Osteopathic Medicine, Camden 08103-1505","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089360212","display_name":"Aly A. Howeedy","orcid":"https://orcid.org/0000-0003-1958-7414","observed_orcids":["https://orcid.org/0000-0003-1958-7414"]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Howeedy","raw_affiliation_strings":["University of Medicine and Dentistry of New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Dentistry of New Jersey","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082851014","display_name":"Andre Kajdacsy\u2010Balla","orcid":"https://orcid.org/0000-0001-8699-762X","observed_orcids":["https://orcid.org/0000-0001-8699-762X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kajdacsy-Balla","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5402,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.92180016,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"65","issue":"3","first_page":"405","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.8320000171661377},{"id":"https://openalex.org/keywords/chronic-alcoholism","display_name":"chronic alcoholism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.7879999876022339},{"id":"https://openalex.org/keywords/complement-c3b-receptor","display_name":"C3b receptor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.9129999876022339},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9409999847412109},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.968999981880188},{"id":"https://openalex.org/keywords/splenic-macrophages","display_name":"splenic macrophages","score":0.9990000128746033},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9340000152587891},{"id":"https://openalex.org/keywords/infection-susceptibility","display_name":"infection susceptibility","score":0.6809999942779541},{"id":"https://openalex.org/keywords/nitroblue-tetrazolium-reduction","display_name":"nitroblue tetrazolium reduction","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.7846391201019287},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7174099683761597},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6302351951599121},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.5541415214538574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4999423027038574},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.49548137187957764},{"id":"https://openalex.org/C2909786458","wikidata":"https://www.wikidata.org/wiki/Q906440","display_name":"Nitroblue tetrazolium","level":2,"score":0.4364500939846039},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.4102550446987152},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39357075095176697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37153780460357666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30401891469955444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2759668231010437},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2267155945301056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11747443675994873},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07552188634872437}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009580","descriptor_name":"Nitroblue Tetrazolium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011951","descriptor_name":"Receptors, Complement","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017463","descriptor_name":"Receptors, Complement 3b","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1385479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:2974831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2974831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:77569205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2974831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1385479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W51804427","https://openalex.org/W87350884","https://openalex.org/W113484857","https://openalex.org/W159390204","https://openalex.org/W1491419518","https://openalex.org/W1507109135","https://openalex.org/W1508260169","https://openalex.org/W1964451971","https://openalex.org/W1981943709","https://openalex.org/W1991336686","https://openalex.org/W2000705310","https://openalex.org/W2005604664","https://openalex.org/W2023122744","https://openalex.org/W2042125074","https://openalex.org/W2069092878","https://openalex.org/W2069690556","https://openalex.org/W2123062093","https://openalex.org/W2154365840","https://openalex.org/W2341578728","https://openalex.org/W2417656174","https://openalex.org/W2418120933","https://openalex.org/W2419566860","https://openalex.org/W2430974860","https://openalex.org/W2473269561"],"related_works":["https://openalex.org/W7144934353","https://openalex.org/W2048533834","https://openalex.org/W2374827049","https://openalex.org/W1990522354","https://openalex.org/W1966283700","https://openalex.org/W2040540356","https://openalex.org/W1979301894","https://openalex.org/W2789659660","https://openalex.org/W2041092512","https://openalex.org/W2149320912"],"abstract_inverted_index":{"In":[0,93],"the":[1,36,76,95],"present":[2],"study,":[3],"we":[4],"have":[5,28],"assessed":[6],"peritoneal,":[7],"alveolar":[8],"and":[9,16,20,56,72,87,108],"splenic":[10],"macrophages":[11,47,65,79,99],"for":[12,70,126],"expression":[13],"of":[14,66,78,97,117,130],"Fc":[15,57,88],"C3b":[17,55,86],"surface":[18,54,62],"receptors":[19,89],"their":[21,31],"ability":[22,77,96],"to":[23,83,103,109,133],"function":[24,119],"in":[25,123],"immunophagocytosis.":[26],"We":[27],"also":[29],"measured":[30],"oxidative":[32],"burst":[33],"response":[34],"by":[35],"nitroblue":[37],"tetrazolium":[38],"dye":[39,112],"(NBT)":[40],"reduction":[41],"method.":[42],"Our":[43],"studies":[44],"revealed":[45],"that":[46],"harvested":[48],"from":[49,80,100],"chronic":[50],"alcoholic":[51,81,101,131],"rats":[52,82],"expressed":[53],"receptors,":[58],"with":[59],"significantly":[60,91],"higher":[61],"density":[63],"than":[64],"litter-mate":[67],"controls":[68],"(matched":[69],"sex":[71],"nutritional":[73],"calories).":[74],"However,":[75],"phagocytize":[84],"through":[85],"was":[90,113],"impaired.":[92],"addition,":[94],"peritoneal":[98],"animals":[102],"ingest":[104],"non-opsonized":[105],"Candida":[106],"albicans":[107],"reduce":[110],"NBT":[111],"markedly":[114],"compromised.":[115],"Abnormalities":[116],"macrophage":[118],"may,":[120],"at":[121],"least":[122],"part,":[124],"account":[125],"an":[127],"increased":[128],"susceptibility":[129],"patients":[132],"infection.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}