{"id":"https://openalex.org/W77510093","doi":null,"title":"Clinical expression, pathophysiological consequences and general health status in elderly individuals with subclinical thyroid dysfunction","display_name":"Clinical expression, pathophysiological consequences and general health status in elderly individuals with subclinical thyroid dysfunction","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W77510093","mag":"77510093"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:3480","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/3480/1/McCahon12PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/3480/1/McCahon12PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/3480/1/McCahon12PhD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048122395","display_name":"Deborah McCahon","orcid":"https://orcid.org/0000-0003-2768-293X","observed_orcids":["https://orcid.org/0000-0003-2768-293X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Deborah McCahon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048122395"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subclinical-thyroid-dysfunction","display_name":"subclinical thyroid dysfunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":0.9800000190734863},{"id":"https://openalex.org/keywords/subclinical-hyperthyroidism","display_name":"subclinical hyperthyroidism","score":1.0},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8560000061988831},{"id":"https://openalex.org/keywords/health-status","display_name":"health status","score":0.6069999933242798},{"id":"https://openalex.org/keywords/symptoms","display_name":"clinical symptoms","score":0.871999979019165},{"id":"https://openalex.org/keywords/thyroid-function","display_name":"thyroid function","score":0.6499999761581421},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.7540000081062317},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/community-dwelling-elderly","display_name":"community-dwelling older adults","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.625},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.952498733997345},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.8036161661148071},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7785011529922485},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.679795503616333},{"id":"https://openalex.org/C2994032529","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid dysfunction","level":3,"score":0.6563249230384827},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5559781789779663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4538078308105469},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45135223865509033},{"id":"https://openalex.org/C2778840127","wikidata":"https://www.wikidata.org/wiki/Q712838","display_name":"Thyroid function tests","level":3,"score":0.4482557475566864},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.41832977533340454},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08122426271438599}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:3480","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/3480/1/McCahon12PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/3480/1/McCahon12PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/991851","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/991851","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:50085","doi":null,"is_oa":false,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/50085","pdf_url":null,"source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:77510093","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/id/eprint/3480/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.bham.ac.uk:3480","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/3480/1/McCahon12PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/3480/1/McCahon12PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W77510093.pdf","grobid_xml":"https://content.openalex.org/works/W77510093.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W171065503","https://openalex.org/W205435761","https://openalex.org/W1506940802","https://openalex.org/W1577362492","https://openalex.org/W1841207238","https://openalex.org/W1847168837","https://openalex.org/W1888479777","https://openalex.org/W1922853791","https://openalex.org/W1968502070","https://openalex.org/W1969874414","https://openalex.org/W1977859968","https://openalex.org/W1978559629","https://openalex.org/W1982063818","https://openalex.org/W1982441219","https://openalex.org/W1983198822","https://openalex.org/W1984069455","https://openalex.org/W1984161074","https://openalex.org/W1984273763","https://openalex.org/W1984375821","https://openalex.org/W1984653373","https://openalex.org/W1988355520","https://openalex.org/W1988454911","https://openalex.org/W1994466395","https://openalex.org/W2000504772","https://openalex.org/W2002712369","https://openalex.org/W2003253893","https://openalex.org/W2004525296","https://openalex.org/W2004680931","https://openalex.org/W2006617550","https://openalex.org/W2007313418","https://openalex.org/W2007425077","https://openalex.org/W2012710287","https://openalex.org/W2013146329","https://openalex.org/W2015705415","https://openalex.org/W2016111447","https://openalex.org/W2016594484","https://openalex.org/W2020928744","https://openalex.org/W2022331200","https://openalex.org/W2023374432","https://openalex.org/W2024021083","https://openalex.org/W2028785373","https://openalex.org/W2028873098","https://openalex.org/W2030459256","https://openalex.org/W2030663585","https://openalex.org/W2031012775","https://openalex.org/W2032931046","https://openalex.org/W2033092223","https://openalex.org/W2033152833","https://openalex.org/W2033555047","https://openalex.org/W2035929479","https://openalex.org/W2038826776","https://openalex.org/W2040302192","https://openalex.org/W2042626693","https://openalex.org/W2043015190","https://openalex.org/W2047227056","https://openalex.org/W2051583714","https://openalex.org/W2058853709","https://openalex.org/W2060164324","https://openalex.org/W2061039464","https://openalex.org/W2062049719","https://openalex.org/W2062790572","https://openalex.org/W2065265313","https://openalex.org/W2065314794","https://openalex.org/W2068309857","https://openalex.org/W2068366212","https://openalex.org/W2070681224","https://openalex.org/W2071281096","https://openalex.org/W2071898749","https://openalex.org/W2073150696","https://openalex.org/W2074588161","https://openalex.org/W2074862093","https://openalex.org/W2078478011","https://openalex.org/W2081862221","https://openalex.org/W2083193254","https://openalex.org/W2084035305","https://openalex.org/W2085556990","https://openalex.org/W2085643661","https://openalex.org/W2087975771","https://openalex.org/W2089266362","https://openalex.org/W2089290117","https://openalex.org/W2089937750","https://openalex.org/W2093073099","https://openalex.org/W2093341819","https://openalex.org/W2095260570","https://openalex.org/W2096578639","https://openalex.org/W2097165278","https://openalex.org/W2099037065","https://openalex.org/W2099864259","https://openalex.org/W2102435112","https://openalex.org/W2103885433","https://openalex.org/W2104645184","https://openalex.org/W2104910847","https://openalex.org/W2105881004","https://openalex.org/W2107116656","https://openalex.org/W2112015452","https://openalex.org/W2113094284","https://openalex.org/W2114636478","https://openalex.org/W2114768062","https://openalex.org/W2116450237","https://openalex.org/W2117213171","https://openalex.org/W2117664343","https://openalex.org/W2119950851","https://openalex.org/W2120126551","https://openalex.org/W2120761162","https://openalex.org/W2120863778","https://openalex.org/W2123373033","https://openalex.org/W2124070026","https://openalex.org/W2126991953","https://openalex.org/W2128219988","https://openalex.org/W2129417848","https://openalex.org/W2132097862","https://openalex.org/W2132962816","https://openalex.org/W2135259853","https://openalex.org/W2140936682","https://openalex.org/W2140986572","https://openalex.org/W2145298460","https://openalex.org/W2148113299","https://openalex.org/W2149011383","https://openalex.org/W2149430505","https://openalex.org/W2152497658","https://openalex.org/W2153271244","https://openalex.org/W2155797561","https://openalex.org/W2161197885","https://openalex.org/W2162946054","https://openalex.org/W2166281097","https://openalex.org/W2166347921","https://openalex.org/W2169217046","https://openalex.org/W2169347370","https://openalex.org/W2169482975","https://openalex.org/W2170461187","https://openalex.org/W2176125986","https://openalex.org/W2225403061","https://openalex.org/W2253590988","https://openalex.org/W2272489786","https://openalex.org/W2273068525","https://openalex.org/W2318972260","https://openalex.org/W2324628668","https://openalex.org/W2325705904","https://openalex.org/W2428898097","https://openalex.org/W2431867519","https://openalex.org/W2432872240","https://openalex.org/W2945357841","https://openalex.org/W4243976325","https://openalex.org/W4301795256"],"related_works":["https://openalex.org/W3000435595","https://openalex.org/W1987236123","https://openalex.org/W2094601764","https://openalex.org/W186153879","https://openalex.org/W2102435112","https://openalex.org/W2464035790","https://openalex.org/W1970326917","https://openalex.org/W2043015190","https://openalex.org/W2027986844","https://openalex.org/W2087194312"],"abstract_inverted_index":{"Subclinical":[0],"thyroid":[1,68],"dysfunction":[2],"(SCTD),":[3],"characterised":[4],"by":[5],"abnormal":[6],"serum":[7],"thyrotrophin":[8],"concentrations":[9],"(TSH)":[10],"with":[11,58,147,167,177],"normal":[12],"free":[13],"thyroxine":[14],"(FT\\\\(_4\\\\)),":[15],"is":[16,190],"regularly":[17],"encountered":[18],"in":[19,32,35,55,76,106,149,173,183],"primary":[20],"care.":[21],"The":[22],"clinical":[23,48,164],"manifestations":[24],"of":[25,53,109,113,126,156,171],"SCTD":[26,54,148,172],"are":[27],"not":[28,145,162],"well":[29],"established,":[30],"particularly":[31],"older":[33],"individuals":[34,79],"whom":[36],"SCTD,":[37,184],"co-morbid":[38],"conditions":[39],"and":[40,50,63,73,83,98,140,158],"symptoms":[41,75,114,117,139,157],"frequently":[42],"occur.":[43],"This":[44],"thesis":[45],"clarifies":[46],"the":[47,56,107,124,174],"expression":[49],"pathophysiological":[51,181],"consequences":[52,182],"elderly":[57],"reference":[59],"to":[60,169,192],"existing":[61],"evidence":[62,179],"a":[64],"cross-sectional":[65],"study":[66],"evaluating":[67],"function":[69],"(TF),":[70],"health":[71,131,142,159],"status":[72,132,143,160],"specific":[74],"community":[77],"dwelling":[78],"aged":[80],"65":[81],"years":[82],"above.":[84],"TF":[85,121],"for":[86,196],"2870":[87],"participants":[88],"was":[89],"categorised,":[90],"2703":[91],"(94%)":[92],"euthyroid,":[93],"138":[94],"(4.8%)":[95],"subclinical":[96,101],"hypothyroidism":[97],"29":[99],"(1%)":[100],"hyperthyroidism.":[102],"No":[103],"significant":[104],"differences":[105],"prevalence":[108],"individual":[110,127],"symptoms,":[111,130],"pairs":[112],"or":[115,128],"multiple":[116,129],"were":[118,134,144],"observed":[119],"between":[120],"groups.":[122],"In":[123,137],"presence":[125],"scores":[133],"significantly":[135],"lower.":[136],"conclusion,":[138],"impaired":[141],"associated":[146],"this":[150,188],"study.":[151],"Results":[152],"suggest":[153,187],"that":[154],"assessment":[155],"does":[161],"aid":[163],"decision":[165],"making":[166],"respect":[168],"management":[170],"elderly.":[175],"Coupled":[176],"weak":[178],"demonstrating":[180],"overall":[185],"findings":[186],"population":[189],"unlikely":[191],"benefit":[193],"from":[194],"treatment":[195],"SCTD.":[197]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
