{"id":"https://openalex.org/W77505154","doi":null,"title":"Estimation of peroxidative damage. A critical review.","display_name":"Estimation of peroxidative damage. A critical review.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W77505154","mag":"77505154","pmid":"https://pubmed.ncbi.nlm.nih.gov/8734296"},"language":"en","primary_location":{"id":"pmid:8734296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8734296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologie-biologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111793177","display_name":"H. Esterbauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"H Esterbauer","raw_affiliation_strings":["Institute of Biochemistry, University of Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, University of Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111793177"],"corresponding_institution_ids":["https://openalex.org/I15766117"],"apc_list":null,"apc_paid":null,"fwci":2.4775,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.90505618,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"44","issue":"1","first_page":"25","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.996999979019165},{"id":"https://openalex.org/keywords/peroxidative-damage","display_name":"peroxidative damage","score":0.8510000109672546},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.8059999942779541},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8339999914169312},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phospholipid-hydroperoxides","display_name":"phospholipid hydroperoxides","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lipofuscin","display_name":"lipofuscin","score":0.75},{"id":"https://openalex.org/keywords/protein-adducts","display_name":"protein adducts","score":0.746999979019165},{"id":"https://openalex.org/keywords/exhaled-breath-condensate","display_name":"exhaled breath condensate","score":0.7649999856948853},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.5289999842643738},{"id":"https://openalex.org/keywords/immunological-testing","display_name":"immunological tests","score":0.6499999761581421},{"id":"https://openalex.org/keywords/oxidative-stress-biomarkers","display_name":"oxidative stress biomarkers","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.9145122766494751},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.8842607736587524},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7397605180740356},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.6417315602302551},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5761302709579468},{"id":"https://openalex.org/C2779308327","wikidata":"https://www.wikidata.org/wiki/Q229982","display_name":"4-Hydroxynonenal","level":4,"score":0.5380465984344482},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4375251829624176},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2933410406112671}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007159","descriptor_name":"Immunologic Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8734296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8734296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathologie-biologie","raw_type":"Journal Article"},{"id":"mag:77505154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8734296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163137554","https://openalex.org/W2316134321","https://openalex.org/W2109977819","https://openalex.org/W7096163132","https://openalex.org/W1572179400","https://openalex.org/W4403983683","https://openalex.org/W2387954900","https://openalex.org/W4388247661","https://openalex.org/W2161948483","https://openalex.org/W1993319802"],"abstract_inverted_index":{"Numerous":[0],"methods":[1],"have":[2],"been":[3],"developed":[4],"to":[5],"measure":[6],"lipid":[7,11,104,150],"peroxidation":[8,12,105,151],"products":[9,106,152],"and":[10,17,42,100,116,122],"damage":[13],"in":[14,58,124],"tissues,":[15],"cells":[16],"body":[18],"fluids.":[19],"The":[20,64,118],"choice":[21],"of":[22,35,47,66,82,120],"which":[23],"method":[24],"is":[25,57,131],"most":[26,59],"appropriate":[27],"depends,":[28],"amongst":[29],"others,":[30],"on":[31],"the":[32,36,39,45,61,67,125,132],"specific":[33],"interest":[34],"investigator.":[37],"In":[38],"routine":[40],"clinical":[41],"laboratory":[43],"praxis,":[44],"determination":[46],"thiobarbituric":[48],"acid":[49],"reactive":[50],"substances":[51],"(TBARS)":[52],"under":[53],"strictly":[54],"standardized":[55],"conditions":[56],"cases":[60],"first":[62],"choice.":[63],"specificity":[65],"colorimetric":[68],"or":[69,156],"fluorimetric":[70],"assay":[71],"can":[72,163],"be":[73,91,164],"significantly":[74],"improved":[75],"if":[76],"combined":[77],"with":[78],"HPLC.":[79],"If":[80],"levels":[81],"TBARS":[83],"are":[84,96],"increased,":[85],"other":[86],"more":[87],"sophisticated":[88],"assays":[89,142,168],"should":[90],"performed":[92],"for":[93,145],"verification.":[94],"Assays":[95],"available":[97,134],"for:":[98],"Phospholipid-":[99],"cholesterylester":[101],"hydroperoxides,":[102],"aldehydic":[103],"including":[107],"4-hydroxynonenal,":[108],"fluorescent":[109],"protein":[110],"adducts":[111],"(e.g.":[112,153],"lipofuscin),":[113],"conjugated":[114],"dienes":[115],"antioxidants.":[117],"measurement":[119],"pentane":[121],"ethane":[123],"exhaled":[126],"air":[127],"by":[128,149],"gas":[129],"chromatography":[130],"only":[133],"non-invasive":[135],"method.":[136],"Several":[137],"laboratories":[138],"currently":[139],"develop":[140],"immunological":[141],"(ELISA,":[143],"RIA)":[144],"determining":[146],"proteins":[147],"modified":[148,160],"malonaldehyde,":[154],"4-hydroxynonenal)":[155],"autoantibodies":[157],"against":[158],"oxidatively":[159],"proteins.":[161],"It":[162],"expected":[165],"that":[166],"such":[167],"will":[169],"soon":[170],"gain":[171],"diagnostic":[172],"importance.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}