{"id":"https://openalex.org/W77486236","doi":null,"title":"Astrocytes within the hypothalamic arcuate nucleus contain estrogen-sensitive peroxidase, bind fluorescein-conjugated estradiol, and may mediate synaptic plasticity in the rat.","display_name":"Astrocytes within the hypothalamic arcuate nucleus contain estrogen-sensitive peroxidase, bind fluorescein-conjugated estradiol, and may mediate synaptic plasticity in the rat.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W77486236","mag":"77486236","pmid":"https://pubmed.ncbi.nlm.nih.gov/1849705"},"language":"en","primary_location":{"id":"pmid:1849705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1849705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of obstetrics and gynecology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103281088","display_name":"David L. Keefe","orcid":"https://orcid.org/0009-0001-2942-2886","observed_orcids":["https://orcid.org/0009-0001-2942-2886","https://orcid.org/0000-0002-8599-9591"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Keefe","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001391599","display_name":"D S Michelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D S Michelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045057312","display_name":"S H Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030184373","display_name":"Frederick Nicholas Naftolin","orcid":"https://orcid.org/0000-0002-9447-6266","observed_orcids":["https://orcid.org/0000-0002-9447-6266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Naftolin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3582,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.77973258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"164","issue":"4","first_page":"959","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hypothalamic-arcuate-nucleus","display_name":"hypothalamic arcuate nucleus","score":0.9490000009536743},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.7039999961853027},{"id":"https://openalex.org/keywords/peroxidase","display_name":"peroxidase","score":0.871999979019165},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/estradiol-binding","display_name":"estradiol binding","score":0.7559999823570251},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.7390000224113464},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7710000276565552},{"id":"https://openalex.org/keywords/synaptic-remodeling","display_name":"synaptic remodeling","score":0.5860000252723694},{"id":"https://openalex.org/keywords/neuron-astrocyte-interactions","display_name":"astrocyte-neuron interaction","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7244400382041931},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6773037314414978},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.610720157623291},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.47840532660484314},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.4622684717178345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.455434650182724},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44848477840423584},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.44466251134872437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44387301802635193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4339863955974579},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.3965858817100525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39151954650878906},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37050628662109375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3099818527698517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11868712306022644},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08573824167251587},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019793","descriptor_name":"Fluorescein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1849705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1849705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of obstetrics and gynecology","raw_type":"Journal Article"},{"id":"mag:77486236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1849705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030933570","https://openalex.org/W2057961626","https://openalex.org/W2014394921","https://openalex.org/W7095395498","https://openalex.org/W1979065856","https://openalex.org/W2047509746","https://openalex.org/W2025554178","https://openalex.org/W2050181993","https://openalex.org/W2075564085","https://openalex.org/W2085405074"],"abstract_inverted_index":{"Estrogen":[0,109],"treatment":[1],"induces":[2],"synaptic":[3,78],"plasticity":[4,24],"accompanied":[5],"by":[6,54,97,116],"damaged":[7],"structures":[8],"and":[9,122,183,198,205],"aggregates":[10],"of":[11,20,34,39,58,71,126,143,151,171,180,193,212],"peroxidase":[12,41,49,103,112,197,204],"in":[13,15,46,68,120,140,148,166],"astrocytes":[14,89,115,139,147],"the":[16,21,28,37,56,81,124,141,149,152,176,190,213,215],"hypothalamic":[17],"arcuate":[18,29,82],"nucleus":[19,30],"rat.":[22],"Synaptic":[23],"also":[25],"occurs":[26],"within":[27,80,113,175],"after":[31],"physiologic":[32],"surges":[33],"estrogen.":[35,62],"Although":[36,84,146],"function":[38],"estrogen-induced":[40,73],"is":[42,218],"unclear":[43],"at":[44],"present,":[45],"other":[47],"systems":[48],"can":[50],"generate":[51],"free":[52,64,74],"radicals":[53,65,75],"catalyzing":[55],"oxidation":[57],"some":[59,106,127],"molecules,":[60],"including":[61],"Because":[63],"underlie":[66],"remodeling":[67,79],"a":[69],"number":[70],"tissues,":[72],"could":[76,110,135],"mediate":[77],"nucleus.":[83],"they":[85,161],"contain":[86,92,156],"estrogen-inducible":[87,102],"peroxidase,":[88],"do":[90,154,162],"not":[91,155,219],"estrogen":[93,134,144,159],"receptors":[94,119],"as":[95],"measured":[96],"conventional":[98],"techniques,":[99],"suggesting":[100],"that":[101,129,179],"arises":[104],"from":[105],"novel":[107],"mechanism.":[108],"induce":[111],"receptor-deficient":[114],"binding":[117,174,220],"to":[118,221],"neurons":[121],"stimulating":[123],"release":[125],"factor":[128],"interacts":[130],"with":[131,189],"astrocytes.":[132],"Alternatively,":[133],"act":[136],"directly":[137],"on":[138],"absence":[142],"receptors.":[145],"hypothalamus":[150,177],"rat":[153],"classical":[157],"nuclear":[158],"receptors,":[160],"bind":[163],"fluorescein-conjugated":[164,172,199,206,216],"estradiol":[165,173,200,207,217],"extranuclear":[167],"sites.":[168],"The":[169],"distribution":[170],"overlaps":[178],"peroxidase-rich":[181],"astrocytes,":[182,194],"double":[184],"labeling":[185],"reveals":[186],"many":[187],"cells":[188],"stellate":[191],"morphology":[192],"containing":[195],"both":[196],"binding.":[201],"However,":[202],"because":[203],"always":[208],"occupy":[209],"different":[210],"compartments":[211],"cell,":[214],"peroxidase.":[222]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}