{"id":"https://openalex.org/W77467296","doi":"https://doi.org/10.1007/978-1-62703-155-4_1","title":"PPARs: History and Advances","display_name":"PPARs: History and Advances","publication_year":2012,"publication_date":"2012-09-27","ids":{"openalex":"https://openalex.org/W77467296","doi":"https://doi.org/10.1007/978-1-62703-155-4_1","mag":"77467296","pmid":"https://pubmed.ncbi.nlm.nih.gov/23100221"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-62703-155-4_1","doi":"https://doi.org/10.1007/978-1-62703-155-4_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-155-4_1","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2478663427","display_name":"Peroxisome Proliferator-Activated Receptors (PPARs)"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110899484","display_name":"Jihan Youssef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihan Youssef","raw_affiliation_strings":["University of Missouri-Kansas City, Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri-Kansas City, Kansas City, MO, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103603218","display_name":"Mostafa Z. Badr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mostafa Z. Badr","raw_affiliation_strings":["University of Missouri-Kansas City, Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri-Kansas City, Kansas City, MO, USA","institution_ids":["https://openalex.org/I75421653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103603218"],"corresponding_institution_ids":["https://openalex.org/I75421653"],"apc_list":null,"apc_paid":null,"fwci":1.0976,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.78649506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"952","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.996999979019165},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":1.0},{"id":"https://openalex.org/keywords/steroid-hormone-receptors","display_name":"steroid hormone receptors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6259999871253967},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fertility-control","display_name":"fertility control","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6947886347770691},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6915327310562134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5193458795547485},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5101411938667297},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.4792492389678955},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.431723415851593},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4304203987121582},{"id":"https://openalex.org/C2779544216","wikidata":"https://www.wikidata.org/wiki/Q411546","display_name":"Steroid hormone receptor","level":5,"score":0.425862193107605},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41269704699516296},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37146276235580444},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3562760353088379},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25107163190841675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2234627604484558},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2113308310508728},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17598071694374084},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15087220072746277},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.10509932041168213},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049674","descriptor_name":"History, 21st Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-62703-155-4_1","doi":"https://doi.org/10.1007/978-1-62703-155-4_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-155-4_1","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:23100221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23100221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Historical Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W193617093","https://openalex.org/W1491552196","https://openalex.org/W1964060221","https://openalex.org/W1978125779","https://openalex.org/W1979761686","https://openalex.org/W1982027543","https://openalex.org/W1984710768","https://openalex.org/W1989321849","https://openalex.org/W1990120674","https://openalex.org/W1990985017","https://openalex.org/W1996514038","https://openalex.org/W1996885736","https://openalex.org/W1998280047","https://openalex.org/W1999533225","https://openalex.org/W2001748051","https://openalex.org/W2003181992","https://openalex.org/W2004282020","https://openalex.org/W2012834939","https://openalex.org/W2021944196","https://openalex.org/W2031283052","https://openalex.org/W2039064135","https://openalex.org/W2041817231","https://openalex.org/W2047730134","https://openalex.org/W2047982128","https://openalex.org/W2061075485","https://openalex.org/W2065485581","https://openalex.org/W2066092624","https://openalex.org/W2068669347","https://openalex.org/W2071070439","https://openalex.org/W2076604793","https://openalex.org/W2081070477","https://openalex.org/W2085234203","https://openalex.org/W2104289043","https://openalex.org/W2107662827","https://openalex.org/W2113328569","https://openalex.org/W2116470680","https://openalex.org/W2120875133","https://openalex.org/W2121241298","https://openalex.org/W2124960266","https://openalex.org/W2158090662"],"related_works":["https://openalex.org/W2338198363","https://openalex.org/W2053319143","https://openalex.org/W1592724966","https://openalex.org/W119943658","https://openalex.org/W2990590954","https://openalex.org/W2124100109","https://openalex.org/W2337706651","https://openalex.org/W1996673384","https://openalex.org/W2351031217","https://openalex.org/W3096289954"],"abstract_inverted_index":{"Peroxisome":[0],"proliferator-activated":[1],"receptors":[2,29],"(PPARs)":[3],"are":[4,115],"members":[5],"of":[6,34,55,69,74,111,119,126],"the":[7,49],"steroid":[8],"hormone":[9],"receptor":[10],"superfamily,":[11],"discovered":[12],"in":[13,38,48,89,121,130],"1990.":[14],"To":[15],"date,":[16],"three":[17],"PPAR":[18,24,82,102],"subtypes":[19],"have":[20,45],"been":[21,46],"identified;":[22],"PPAR\u03b1,":[23],"\u03b2/\u03b4,":[25],"and":[26,41,59,71,84,92,99,113],"PPAR\u03b3.":[27],"These":[28],"share":[30],"a":[31,109],"high":[32],"degree":[33],"homology":[35],"but":[36],"differ":[37],"tissue":[39],"distribution":[40],"ligand":[42],"specificity.":[43],"PPARs":[44],"implicated":[47],"etiology":[50],"as":[51,53,63,94,96,104],"well":[52,95],"treatment":[54],"several":[56],"important":[57],"diseases":[58,112],"pathological":[60],"conditions":[61],"such":[62],"diabetes,":[64],"inflammation,":[65],"senescence-related":[66],"diseases,":[67],"regulation":[68],"fertility,":[70],"various":[72],"types":[73],"cancer.":[75],"Consequently,":[76],"significant":[77],"efforts":[78],"to":[79,107],"discover":[80],"novel":[81],"roles":[83],"delineate":[85],"molecular":[86],"mechanisms":[87],"involved":[88],"their":[90],"activation":[91],"repression":[93],"develop":[97],"safer":[98],"more":[100],"effective":[101],"modulators,":[103],"therapeutic":[105],"agents":[106],"treat":[108],"myriad":[110],"conditions,":[114],"underway.":[116],"This":[117],"volume":[118],"Methods":[120],"Molecular":[122],"Biology":[123],"contains":[124],"details":[125],"experimental":[127],"protocols":[128],"used":[129],"researching":[131],"these":[132],"receptors.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
