{"id":"https://openalex.org/W7738489","doi":null,"title":"Retinitis and deviant immune responses following intravitreal inoculation of HSV-1.","display_name":"Retinitis and deviant immune responses following intravitreal inoculation of HSV-1.","publication_year":1987,"publication_date":"1987-05-01","ids":{"openalex":"https://openalex.org/W7738489","mag":"7738489","pmid":"https://pubmed.ncbi.nlm.nih.gov/3032839"},"language":"en","primary_location":{"id":"pmid:3032839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3032839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W7738489"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016219207","display_name":"Sally S. Atherton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S S Atherton","raw_affiliation_strings":["University of Miami,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami,","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029242903","display_name":"G A Pesicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G A Pesicka","raw_affiliation_strings":["University of Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113888925","display_name":"J. Wayne Streilein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J W Streilein","raw_affiliation_strings":["University of Miami,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami,","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":0.6956,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.70852795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"28","issue":"5","first_page":"859","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/retinitis","display_name":"retinal inflammation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.6980000138282776},{"id":"https://openalex.org/keywords/retinal-necrosis","display_name":"retinal necrosis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/ocular-herpes","display_name":"ocular herpes","score":0.5149999856948853},{"id":"https://openalex.org/keywords/systemic-immune-response","display_name":"systemic immune response","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2777016524","wikidata":"https://www.wikidata.org/wiki/Q630552","display_name":"Retinitis","level":4,"score":0.8736608028411865},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.6447108387947083},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5918379426002502},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5631726980209351},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.5250294804573059},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4884587824344635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48692619800567627},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4853309690952301},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4639747738838196},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.45625030994415283},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.434742271900177},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3941952586174011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31542864441871643},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2716406285762787},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012173","descriptor_name":"Retinitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3032839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3032839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:7738489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3032839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W4238271285","https://openalex.org/W214995755"],"related_works":["https://openalex.org/W2055682001","https://openalex.org/W2115698314","https://openalex.org/W88979424","https://openalex.org/W1554804737","https://openalex.org/W3239780","https://openalex.org/W2053613266","https://openalex.org/W2012682802","https://openalex.org/W4300774291","https://openalex.org/W168094001","https://openalex.org/W2011079510"],"abstract_inverted_index":{"Following":[0],"anterior":[1],"chamber":[2],"inoculation":[3,82,159],"of":[4,14,22,33,39,45,69,83,99,128,131,141,149,155,160,167],"herpes":[5],"simplex":[6],"virus":[7],"type":[8],"1":[9],"(HSV-1)":[10],"into":[11],"one":[12],"eye":[13,79,90,119],"adult,":[15],"immunocompetent":[16],"BALB/c":[17],"mice,":[18],"an":[19],"interesting":[20],"pattern":[21,68],"ocular":[23],"pathology":[24],"and":[25,43,74,125],"systemic":[26],"immune":[27],"responses":[28,143],"emerges,":[29],"characterized":[30,121],"by":[31,50,122],"destruction":[32,111],"the":[34,40,55,62,72,76,88,100,116,129,132],"contralateral":[35,118],"retina":[36],"with":[37,96],"sparing":[38],"ipsilateral":[41],"retina;":[42],"impairment":[44,140],"delayed":[46],"hypersensitivity":[47],"(DH)":[48],"accompanied":[49],"intact":[51],"humoral":[52],"immunity":[53],"to":[54,106,144],"virus.":[56],"Experiments":[57],"using":[58],"animals":[59,137],"inoculated":[60,73,89,136],"via":[61],"intravitreal":[63,81],"route":[64],"revealed":[65],"a":[66,179],"different":[67],"retinitis":[70,86,114],"in":[71,75,87,92,103,108,115,178],"uninoculated":[77,117],"fellow":[78],"following":[80],"HSV-1.":[84],"The":[85,113],"results":[91],"localized,":[93],"focal":[94],"necrosis":[95],"concomitant":[97],"preservation":[98],"retinal":[101,110],"architecture":[102,130],"areas":[104],"juxtaposed":[105],"those":[107],"which":[109],"occurs.":[112],"is":[120],"pan-retinal":[123],"inflammation":[124],"subsequent":[126],"loss":[127],"entire":[133],"retina.":[134],"Intravitreally":[135],"exhibited":[138],"virus-specific":[139],"DH":[142,156],"HSV-1":[145,162],"but":[146],"were":[147],"capable":[148],"producing":[150],"anti-HSV-1":[151],"neutralizing":[152],"antibody.":[153],"Impairment":[154],"response":[157],"after":[158],"live":[161],"suggests":[163],"that":[164,172],"intraocular":[165],"processing":[166],"viral":[168],"antigens":[169,174],"occurs":[170],"such":[171],"processed":[173],"are":[175],"released":[176],"systemically":[177],"soluble":[180],"form.":[181]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}