{"id":"https://openalex.org/W773085616","doi":null,"title":"Suppression of Helicobacter pylori protease activity towards growth factors by sulglycotide.","display_name":"Suppression of Helicobacter pylori protease activity towards growth factors by sulglycotide.","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W773085616","mag":"773085616","pmid":"https://pubmed.ncbi.nlm.nih.gov/9376617"},"language":"en","primary_location":{"id":"pmid:9376617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9376617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012721054","display_name":"J. Piotrowski","orcid":"https://orcid.org/0000-0002-7981-7552","observed_orcids":["https://orcid.org/0000-0002-7981-7552"]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Piotrowski","raw_affiliation_strings":["University of Medicine and Dentistry of New Jersey, Newark, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Dentistry of New Jersey, Newark, USA","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110086237","display_name":"Amalia Slomiany","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Slomiany","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009709770","display_name":"B L Slomiany","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B L Slomiany","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0952,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76332391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"48","issue":"3","first_page":"345","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.996999979019165},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.953000009059906},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9739999771118164},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/gastric-mucosa","display_name":"gastric mucosa","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8700000047683716},{"id":"https://openalex.org/keywords/protease-inhibition","display_name":"protease inhibition","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7612295150756836},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.6920626163482666},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.6338340044021606},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.6139289140701294},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.586158037185669},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5804430842399597},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.5644103288650513},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5376710891723633},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.48548343777656555},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.41430169343948364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4087376296520233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3734956979751587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3667031526565552},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3625822961330414},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3489419221878052},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3486312925815582},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30656740069389343},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24112170934677124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17282170057296753},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16775920987129211}],"mesh":[{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9376617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9376617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:773085616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9376617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2048716983","https://openalex.org/W2474086587","https://openalex.org/W2060703556","https://openalex.org/W3018862998","https://openalex.org/W2058524825","https://openalex.org/W2008513788","https://openalex.org/W7066480679","https://openalex.org/W2111223498","https://openalex.org/W2045667450","https://openalex.org/W2013020333"],"abstract_inverted_index":{"Infection":[0],"with":[1,71,160],"H.":[2,46,72,101,151,204],"pylori":[3,47,73,102,152],"is":[4],"now":[5],"recognized":[6],"as":[7],"a":[8,54,119,125,140,185],"major":[9],"factor":[10,25,30,41],"in":[11,86,143,171,176,193],"the":[12,20,51,77,83,87,98,116,135,150,189,194],"pathogenesis":[13],"of":[14,22,53,79,82,89,108,113,122,128,132,191,196],"gastric":[15,197],"disease.":[16],"Here,":[17],"we":[18],"examined":[19],"susceptibility":[21],"epidermal":[23],"growth":[24,29,33,40,199],"(EGF),":[26],"basic":[27],"fibroblast":[28],"(bFGF),":[31],"transforming":[32],"factor-beta":[34],"(TGF":[35],"beta)":[36],"and":[37,49,67,110,124,145,173],"platelet":[38],"derived":[39],"(PDGF)":[42],"to":[43,134],"degradation":[44,107,112,121,127,179,202],"by":[45,149,203],"protease,":[48,74],"assessed":[50],"effect":[52,157],"cytoprotective":[55],"agent,":[56],"sulglycotide,":[57],"on":[58],"this":[59],"process.":[60],"The":[61,93,154,182],"125I-labeled":[62],"EGF,":[63],"bFGF,":[64],"TGF":[65,129,146,177],"beta":[66,147,178],"PDGF":[68,123,144,172],"were":[69],"incubatet":[70],"obtained":[75,159],"from":[76],"filtrates":[78],"saline":[80],"washes":[81],"bacterium":[84],"culture,":[85],"presence":[88],"0-100":[90],"micrograms":[91],"sulglycotide.":[92],"results":[94,183],"showed":[95],"that,":[96],"under":[97],"assay":[99,137],"conditions,":[100],"protease":[103,117],"caused":[104,139],"only":[105],"5%":[106],"EGF":[109],"7%":[111],"bFGF.":[114],"However,":[115],"evoked":[118],"61.7%":[120],"62.3%":[126],"beta.":[130],"Introduction":[131],"sulglycotide":[133,161,192],"reaction":[136],"system":[138],"dose-dependent":[141],"inhibition":[142],"proteolysis":[148],"enzyme.":[153],"maximal":[155],"inhibitory":[156],"was":[158,180],"at":[162,165],"100":[163],"micrograms/ml,":[164],"which":[166],"dose":[167],"an":[168],"84.4%":[169],"decrease":[170,175],"88.3%":[174],"achieved.":[181],"provide":[184],"strong":[186],"evidence":[187],"for":[188],"effectiveness":[190],"protection":[195],"mucosal":[198],"factors":[200],"against":[201],"pylori.":[205]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}